The CSF Pulse Pressure in Relation to Intracranial Elastance and Failure of Autoregulation
Analogous to the volume-pressure response (VPR), the CSF pulse pressure (CSFPP) is determined by two factors (1): I. the transient increase in cerebral blood volume per cardiac cycle (ΔV); and 2. the shape of the craniospinal volume-pressure (V/P) curve. The CSFPP can therefore be used as a measure of craniospinal elastance, provided ΔV is constant. Observations in patients have shown a linear relationship between CSFPP and intracranial pressure (ICP) implying a constant ΔV in the individual patient (2). At elevated ICP, however, some authors (2,3,4) have found a break point in this relationship above which the CSFPP increased more rapidly. The meaning of this break point is not yet fully understood. In order to study the concept of CSFPP as a parameter of craniospinal elastance, CSFPP was compared with VPR during cerebral compression in dogs. Special attention was paid to the occurrence of a break point and its physiological significance.
Unable to display preview. Download preview PDF.
- 1.Eijndhoven JHM Van, Avezaat CJJ (this volume) The analogy between CSF pulse pressure and volume pressure response. Intracranial Pressure IVGoogle Scholar
- 2.Avezaat CJJ, Van Eijndhoven J H NI, De Jong DA, Moolenaar WCJ (1976) A new method of monitoring intracranial volume pressure relationships. In: Beks JWF, Bosch DA, Brock M (eds) Intracranial Pressure III. Springer, Berlin Heidelberg New York, p 308Google Scholar
- 5.Avezaat CJJ, Van Eijndhoven JHM, Wyper DJ (1979 to be published) The cerebrospinal fluid pulse pressure and the intracranial volume-pressure relationships. J Neurol Neurosurg and PsychiatGoogle Scholar
- 6.Lofgren J, Von Essen C, Zwetnow NN (1973) The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta Neurol Scand 49:574–575Google Scholar