Experimental Brain Injury in the Dog: Pathophysiological Correlation
Despite the utilization of standardized brain injury created by the inflation and subsequent deflation of an epidural balloon, two general response patterns were observed: 1. Absence of significant postdeflation intracranial hypertension and prolonged survival. 2. Postdeflation intracranial pressure (ICP) rise exceeding 40 torr, plateau waves, and brain death within several hours of deflation. This paper aims to provide insight into the causes of the variability in response sto a standardized injury by correlating physiological behavior with autopsy findings.
KeywordsIschemia Urea Neurol Mannitol Pentobarbital
Unable to display preview. Download preview PDF.
- 2.Langfitt T, Kassell N, Weinstein J (1965) Cerebral blood flow with intracranial hypertension. Neurol 15:761–73Google Scholar
- 3.Langfitt T, Winstein J, Kassell N (1965) Cerebral vasomotor Paralysis produced by intracranial hypertension. Neurol 15:622–41Google Scholar
- 4.Weinstein J, Langfitt T, Kassell N (1964) Vasopressor response to increased intracranial pressure. Neurol 14:1118–31Google Scholar