Nitroprusside and Nitroglycerin Induced Intracranial Pressure Changes
Induced hypotension is frequently used in neurosurgical patients for clipping of aneurysm, to reduce blood loss and to provide a relatively bloodless field to decrease operative time. Previous methods to induce hypotension were inadequate due to lack of easy controllability, toxic metabolites or increase in intracranial pressure (ICP). Recently, sodium nitroprusside’s (SNP) popularity in neurosurgical patients has been threatened because of reports of increased ICP(3,5). Nitroglycerin (NTG) has been suggested as an alternate because of reported lack of ICP effects (2). We conducted the present study with NTG and compared it with our previous study.
KeywordsCatheter Depression Lactate Pyruvate Bicarbonate
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