Biochemical Effects of Neuroleptic Drugs

  • G. Bartholini
  • K. G. Lloyd
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)


The biochemical effects of the neuroleptic drugs can be divided according to the following criteria:
  1. a)

    Changes induced by all of these compounds independently of the brain structure upon which they act. These changes, e.g., alteration of DA turnover, are qualitatively similar in all of the DA-rich brain areas and can be considered as common basic effects of neuroleptic compounds.

  2. b)

    Changes induced by all of the neuroleptic drugs but specific for a given brain structure e.g., alteration of acetylcholine (ACh) or γ-aminobutyric acid (GABA) turnover. The preferential occurrence of these changes in specific brain areas is probably explained by the neuronal network proper to each region.

  3. c)

    The above-mentioned effects are typical for all “classical” neuroleptic compounds which differ only in their relative potency (on biochemical and behavioural parameters) and, thus, share a similar pharmacological profile. In contrast, some compounds, which will be referred to as “atypical” neuroleptics, differ from classical drugs as they show a peculiar pharmacological spectrum.



Tyrosine Hydroxylase Substantia Nigra Limbic System Neuroleptic Drug Dopamine Turnover 
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© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • G. Bartholini
  • K. G. Lloyd

There are no affiliations available

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