Antipsychotics and Experimental Seizure Models

  • R. Kretzschmar
  • H. J. Teschendorf
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)


Shortly after the introduction of chlorpromazine into the therapy of schizophrenic psychosis the occurrence of epileptic fits was observed under that therapy. Since then these side effects were also found with numerous other neuroleptics of the pheno-thiazine type and with reserpine (Bein, 1956; Schenker and Herbst, 1963). Synoptic papers on the literature compiled by Logothetis (1967), Itil (1970), and Itil and Myers (1973) mention the incidence of seizures as a clinical side effect of various neuroleptic drug therapies. Itil also considers the changes of the human EEG induced by neuroleptic drugs. In his papers Itil hardly deals with findings obtained in animal experiments on the behavior of neuroleptic drugs in seizure models.


Biogenic Amine Anticonvulsant Effect Clonic Seizure Seizure Threshold Neuroleptic Drug 
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© Springer-Verlag Berlin Heidelberg 1980

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  • R. Kretzschmar
  • H. J. Teschendorf

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