Drug-Induced Alterations in Animal Behavior as a Tool for the Evaluation of Antidepressants: Correlation with Biochemical Effects

  • A. Delini-Stula
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)


Since the fortuitous discovery of the antidepressant activity of imipramine by Kuhn (1957), psychopharmacologists have been striving to elaborate an animal model faithfully reproducing the clinical features of human depression. Such a model would not only make it possible to develop better and more specific drugs for the treatment of depression, but also to advance and facilitate the investigation of the aetiological and pathophysiological mechanisms underlying the disease. Many scientists and psychiatrists doubt, however, that a valid model of depression in animal will ever become available. This point of view arises partly from the assumption that depression is a uniquely human disease, inherent in which are the verbal communication and the expression of the state of the mind.


Animal Behavior Antidepressant Drug Brain Dopamine Behavioral Stimulation Amino Acid Decarboxylase Inhibitor 
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© Springer-Verlag Berlin Heidelberg 1980

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  • A. Delini-Stula

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