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Tricyclic Antidepressants: General Pharmacology

  • I. Møller Nielsen
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)

Abstract

The antidepressant effect of the first tricyclic antidepressant was not predicted by pharmacologists. In fact, a series of analogs to antihistaminics were screened for central depressant effect (Domenjoz and Theobald, 1959) and first tried clinically as tranquilizers. The recognition of the antidepressant activity of imipramine was due to the serindipity of Kuhn (1957). Following that, pharmacologists began the search for proper animal models to characterize this property of drugs and investigate for possible modes of action. Since then a large number of derivatives have been synthesized, most of which belong to the group of tricyclic antidepressants; a few nontricyclic compounds with antidepressant activity and with largely the same pharmacologic profile of action will be included in the discussion.

Keywords

Antidepressant Drug Antidepressant Effect Uptake Inhibition Nictitate Membrane Spontaneous Motor Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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