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Chemistry (Structure and Activity)

  • Chapter
Psychotropic Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 55 / 1))

Abstract

Antidepressant activity in the human has been described for a large number of compounds and it is difficult to organize the available data in a systematic way. Here they are grouped not into strict chemical classes but according to major research topics. Although some of the tricyclic major tranquillizers described in Chap. 1 such as Thioridazine (Overall et al., 1964) and Flupenthixol (Young et al., 1976) also show clinically useful antidepressant activity, the chapter on thymoleptics (Chap. 16) starts with a discussion of imipramine, which was the first thymoleptic compound not to show additional neuroleptic activity.

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  1. F. J. Zeelen
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  1. Institut für Pharmakologie, Bayer AG, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    F. Hoffmeister

  2. Institut für Arzneimittel des Bundesgesundheitsamtes, StauffenbergstraÜe 13, D-100, Berlin 30, Germany

    G. Stille

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Zeelen, F.J. (1980). Chemistry (Structure and Activity). In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67538-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-67538-6_16

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