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Chemistry (Structure and Activity)

  • F. J. Zeelen
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)

Abstract

Antidepressant activity in the human has been described for a large number of compounds and it is difficult to organize the available data in a systematic way. Here they are grouped not into strict chemical classes but according to major research topics. Although some of the tricyclic major tranquillizers described in Chap. 1 such as Thioridazine (Overall et al., 1964) and Flupenthixol (Young et al., 1976) also show clinically useful antidepressant activity, the chapter on thymoleptics (Chap. 16) starts with a discussion of imipramine, which was the first thymoleptic compound not to show additional neuroleptic activity.

Keywords

Antidepressant Activity Noradrenaline Reuptake Psychotropic Agent Noradrenaline Uptake Serotonin Uptake Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1980

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  • F. J. Zeelen

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