Chemistry (Structure and Activity)

  • F. J. Zeelen
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)


Antidepressant activity in the human has been described for a large number of compounds and it is difficult to organize the available data in a systematic way. Here they are grouped not into strict chemical classes but according to major research topics. Although some of the tricyclic major tranquillizers described in Chap. 1 such as Thioridazine (Overall et al., 1964) and Flupenthixol (Young et al., 1976) also show clinically useful antidepressant activity, the chapter on thymoleptics (Chap. 16) starts with a discussion of imipramine, which was the first thymoleptic compound not to show additional neuroleptic activity.


Antidepressant Activity Noradrenaline Reuptake Psychotropic Agent Noradrenaline Uptake Serotonin Uptake Inhibitor 
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© Springer-Verlag Berlin Heidelberg 1980

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  • F. J. Zeelen

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