Metabolism and Kinetics

  • U. Breyer-Pfaff
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 1)


Neuroleptic drugs act principally on the central nervous system. This implies that they are lipophilic compounds which easily penetrate membranes separating single body compartments from one another. As a consequence, their excretion will ordinarily be preceded by biotransformation to more hydrophilic substances, since otherwise binding to tissues and plasma proteins and renal tubular reabsorption would lead to an extremely long persistence in the body. Thus, metabolic transformations become limiting for the elimination of the majority of these drugs.


Neuroleptic Drug Piperazine Ring Fluphenazine Decanoate Limited Brain Phenothiazine Drug 
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© Springer-Verlag Berlin Heidelberg 1980

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  • U. Breyer-Pfaff

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