Skip to main content
SpringerLink
Log in

Quantitative Assessment of Thallium-201 Images

  • Conference paper
Cardiac Nuclear Medicine

  • 65 Accesses

Abstract

The sensitivity and specificity of thallium-201 myocardial imaging for analysis of regional myocardial viability depends on reproducible image construction and interpretation. Reproducibility is influenced by the myocardial 201Tl uptake, which depends on myocardial perfusion, mass, and metabolism [25, 26]; these factors also determine the myocardial-to-background ratio [7, 14, 15]. Uptake is, in addition, affected by exercise techniques [22], dosage and type of cardiac pharmaceuticals [7, 13, 15, 26], technical equipment, and the methods used for data collection, processing, and display [16]. Accurate interpretation is often difficult, even for experienced investigators. To overcome this problem two techniques are employed: (1) grading analogue images by quality (poor, adequate, or excellent) and by uptake (normal, borderline, or abnormal) [27], and (2) grading of digital images with Computer assistance [3–11, 13–18, 20–22].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alderson, P.O., Wagner, H.N., Gomez-Moeiras, J.J., Rehn, T.G., Becker, L.C., Douglas, K.H., Manspeaker, H.F., Schindledecker, G.R.: Simultaneous detection of myocardial perfusion and wall motion abnormalities by cinematic 201T1 imaging. Radiology 127: 531–533, 1978

    PubMed  CAS  Google Scholar 

  2. Atkins, H.L., Budinger, T.F., Lebowitz, E., Ansari, A.N., Greene, M.W., Fairchild, R.G., Ellis, K.J.: Thallium-201 for medical use. Part 3: Human distribution and physical imaging properties. J. Nucl. Med. 18: 133–140, 1977

    CAS  Google Scholar 

  3. Blood, D.K., McCarthy, D.M., Sciacca, R.R., Cannon, P.J.: Comparison of single-dose and double-dose thallium-201 myocardial perfusion scintigraphy for the detection of coronary artery disease and prior myocardial infarction. Circulation 58: 777–788, 1978

    Article  PubMed  CAS  Google Scholar 

  4. Bodenheimer, M.M., Bänke, V.S., Fooshee, C, Hermann, G.A., Helfant, R.H.: Relationship between regional myocardial perfusion and the presence, severity and reversibility of asynergy in patients with coronary heart disease. Circulation 58: 789–795, 1978

    Article  PubMed  CAS  Google Scholar 

  5. Buell, U., Niendorf, H.P., Strauer, B.E., Hast, B.: Evaluation of myocardial function with the 2 0 1 thallium scintimetry in various diseases of the heart: A correlative study based on 100 patients. Europ. J. Nucl. Med. 1: 125–136, 1976

    Google Scholar 

  6. Buell, U., Strauer, B.E., Witte, J.: Segmental analysis of Tl-201 stress myocardial scintigraphy: The problem of using uniform normal values of Tl-201 myocardial uptake (letter). J. Nucl. Med. 18: 1240–1241, 1977

    PubMed  CAS  Google Scholar 

  7. Buell, U., Strauer, B.E., Bürger, S., Witte, J., Niendorf, H.P.: Effects of physical stress and pharmacologically induced coronary dilation on myocardial and non-myocardial 201thalliumuptake. Europ. J. Nucl. Med. 3:19-27, 1978

    CAS  Google Scholar 

  8. Cook, DJ., Bailey, I., Strauss, H.W., Rouleau, J., Wagner, H.N., Jr., Pitt, B.: Thallium-201 for myocardial imaging: Appearance of the normal heart. J. Nucl. Med. 17: 583–589, 1976

    PubMed  CAS  Google Scholar 

  9. Emrich, D., Rentrop, P., Facorro, L., Karsch, R., Schicha, H., Carstens, B., Kreuzer, H.: Limitations of thallium-201 scintigraphy for evaluation of chronic ischemic heart disease (abstract) World Federation of Nuclear Medicine and Biology: Second International Congress, Washington D.C., Sept. 17-21, 1978, p. 50

    Google Scholar 

  10. Faris, J.V., Burt, R.W., Graham, M.C., Knoebel, S.B.: Improved sensitivity in detecting coronary artery disease using Computer Statistical analysis of thallium-201 scans. World Federation of Nuclear Medicine and Biology: Second International Congress, Washington D.C., Sept. 17-21, 1978, p. 93

    Google Scholar 

  11. Fletcher, J.W., Walter, K.E., Witztum, K.F., Daly, J.L., Herbig, F.K., Mueller, H.S., Donati, R.M.: Diagnosis of coronary artery disease with 201: Computer analysis of myocardial perfusion images. Radiology 128: 423–427, 1978

    PubMed  CAS  Google Scholar 

  12. Goris, M.L., Daspit, S.G., McLaughhn, P., Kriss, J.P.: Interpolative background subtraction. J. Nucl. Med. 17: 744–747, 1976

    PubMed  CAS  Google Scholar 

  13. Gould, K.L., Westcott, R.J., Albro, P.C., Hamilton, G.W.: Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. II. Clinical methodology and feasibility. Am. J. Cardiol. 41: 279–287, 1978

    Article  PubMed  CAS  Google Scholar 

  14. Hamilton, G.W., Trobaugh, G.B., Ritchie, J.L., Williams, D.L., Weaver, W.D., Gould, K.L.: Myocardial imaging with intravenously injected thallium-201 in patients with suspected coronary artery disease: Analysis of technique and correlation with electrocardiographic, coronary anatomic and ventnculographic findings. Am. J. Cardiol. 39: 347–354, 1977

    Article  PubMed  CAS  Google Scholar 

  15. Hamilton, G.W., Narahara, K.A., Yee, H., Ritchie, J.L., Williams, D.L., Gould, K.L.: Myocardial imaging with thallium-201: Effect of cardiac drugs on myocardial images and absolute tissue distribution. J. Nucl. Med. 19: 10–16, 1978

    PubMed  CAS  Google Scholar 

  16. Hamilton, G.W., Ritchie, J.L., Williams, D.L.: Specialized Computer aquisition, analysis and display of thallium-201 myocardial images. In: Thallium-201 Myocardial Imaging, edited by J.L. Ritchie, G.W. Hamilton, F.J.Th. Wackers. New York, Raven Press, 1978, pp. 133–150

    Google Scholar 

  17. Hör, G., Sebening, H., Sauer, E., Lichte, H., Dressler, J., Lutilsky, L., Wagner-Manslan, C, Pabst, H.W.: Clinical experience with 201Tl-myocardial scintigraphy (redistribution analysis) and ECG-gated blood pool scan. Herz 2: 215–216, 1977

    Google Scholar 

  18. Lenaers, A., Block, P., Thiel, van E., Lebedelle, M., Becquevort, P., Erbsmann, F., Ermans, A.M.: Segmental analysis of Tl-201 stress myocardial scintigraphy. J. Nucl. Med. 18: 509–516, 1977

    PubMed  CAS  Google Scholar 

  19. Maseri, A., Parodi, O., Severi, S., Pesola, A.: Transient transmural reduction of myocardial blood flow, demonstrated by thallium-201 scintigraphy, as a cause of variant angina. Circulation 54: 280–288, 1976

    Article  PubMed  CAS  Google Scholar 

  20. Mathey, D., Montz, R., Hanrath, P., Knop, J., Kupper, W., Schneider, C, Bleifeld, W.: Reversible Myokardischämie oder irreversible Myokardfibrose? Dt. Med. Wochenschr. 103: 1736–1739, 1978

    Article  CAS  Google Scholar 

  21. McKillop, J.H., Bessent, R.G., Murray, R.G., Turner, J.G., Tweddel, A., Greig, W.R.: Quantitative approach to the analysis of the normal thallium-201 myocardial image. Europ. J. Nucl. Med. 3: 223–225, 1978

    CAS  Google Scholar 

  22. McLaughlin, P.R., Martin, R.P., Doherty, P., Daspit, S., Goris, M., Haskell, W., Lewis, S., Kriss, J.P., Harrison, D.C: Reproducibility of thallium-201 myocardial imaging. Circulation 55: 497–503, 1977

    Article  PubMed  CAS  Google Scholar 

  23. Narahara, K.A., Hamilton, G.W., Wiliams. D.L., Gould, K.L.: Myocardial imaging with thallium-201: An experimental model for analysis of true myocardial and background image components. J. Nucl. Med. 18: 781–786, 1977

    PubMed  CAS  Google Scholar 

  24. Nishiyama, H., Romhilt, D.W., Williams, C.C, Adolph, R.J., Sodd, V.J., Blue, J.W., Lewis, J.T., Gabel, M., van der Bei Kahn, J.M.: Collimator evaluation for Tl-201 myocardial imaging. J. Nucl. Med. 19: 1067–1073, 1978

    PubMed  CAS  Google Scholar 

  25. Strauer, B.E., Bürger, S., Buell, U.: Multifactoral determination of 201 thallium uptake of the heart: an experimental study concerning the influence of ventricular mass, perfusion and oxygen consumption. Basic Res. Cardiol. 73: 298–306, 1978

    Article  PubMed  CAS  Google Scholar 

  26. Strauer, B.E., Buell, U., Bürger, S.: Clinical studies concerning the determinants of myocardial 201T1 uptake. Basic Res. Cardiol. 73: 365–379, 1978

    Article  PubMed  CAS  Google Scholar 

  27. Trobaugh, G.B., Wackers, F.J.Th., Sokole, E.B., De Rouen, T.A., Ritchie, J.L., Hamilton, G.W.: Thallium-201 myocardial imaging: An interinstitutional study of observer variability. J. Nucl. Med. 19: 359–363, 1978

    PubMed  CAS  Google Scholar 

  28. Vogel, R.A., Kirch, D., LeFree, M., Steele, P.: A new method of multiplanar emission tomography using a seven pinhole collimator and an anger scintillation camera. J. Nucl. Med. 19: 648–654, 1978

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radiologische Klinik und Poliklinik der Universität München, Medizinische Klinik I der Universität München, Klinikum Grosshadern, München, Germany

    U. Buell, E. Kleinhans, M. Seiderer & B. E. Strauer

Authors
  1. U. Buell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Kleinhans
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Seiderer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. E. Strauer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA

    B. Leonard Holman M.D.  & Herbert L. Abrams M.D.  & 

  2. Radiologisches Zentrum, Klinikum Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Eberhard Zeitler (Prof. Dr.) (Prof. Dr.)

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Buell, U., Kleinhans, E., Seiderer, M., Strauer, B.E. (1979). Quantitative Assessment of Thallium-201 Images. In: Holman, B.L., Abrams, H.L., Zeitler, E. (eds) Cardiac Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67510-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67510-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09803-4

  • Online ISBN: 978-3-642-67510-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation