Skip to main content
SpringerLink
Log in
Book cover

Adrenergic Activators and Inhibitors pp 499–519Cite as

Behavioural Pharmacology Reflecting Catecholamine Neurotransmission

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 54 / 1))

Abstract

The combination of a growing knoweledge in catecholamine neuron anatomy and powerful morphological and pharmacological tools has opened up the possibility of investigating the role of catecholamine neurons in essentially every known brain function. A number of excellent reviews have been written on the subject. (Cooper et al., 1974; Friedhoff, 1975a, b; Barnett, 1975; Marshall, 1976; Antelman and Caggiula, 1977, Engel and Carlsson, 1977; Seiden and Dykstra, 1977; Crow, 1977; Fibinger, 1978; Fuxe, 1978; Ungerstedt, 1974a, b, 1979; Ungerstedt et al., 1977, 1978). The wealth of available information has given me the moral support to refrain from attempting an exhaustive review and instead take the liberty of focusing the attention on a limited range of subjects. However, it is my hope that this will lead the reader towards some of the more interesting concepts of catecholamines and behaviour that are now emerging.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amsler, C.: Beiträge zur Pharmakologie des Gehirns. Naunyn-Schmiedeberg’s Arch. exp. Pa-thol. Pharmacol. 97, 1–14 (1923)

    CAS  Google Scholar 

  • Andén, N.-E., Johnels, B.: Effect of local application of apomorphine to the reserpine-induced rigidity in rats. Brain Res. 133, 386–389 (1977)

    Article  PubMed  Google Scholar 

  • Andén, N.-E., Dahlström, A., Fuxe, K., Larsson, K.: Functional role of the nigroneostriatal dopamine neurons. Acta Pharmacol. Toxicol. (Kbh.) 24, 263–274 (1966)

    Google Scholar 

  • Andén, N.-E., Bedard, P., Fuxe, K., Ungerstedt, U.: Early and selective increase in brain dopamine levels after axotomy. Experientia 28, 300–301 (1972)

    Article  PubMed  Google Scholar 

  • Antelman, S.M., Caggiula, A.R.: Norepinephrine-dopamine interactions and behavior. Science 195, 646–653 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Axelrod, J., Zatz, M.: The adrenergic receptor and the regulation of circadian rhythms in the pineal gland. In: Biochemical actions hormones. Gerald Litwack (ed.), pp. 249–266. New York: Academic Press 1977

    Google Scholar 

  • Barnett, A.: Dopamine receptors and their role in brain functions. Curr. Dev. Psychopharmacol. 1, 1–35 (1975)

    CAS  Google Scholar 

  • Buus Lassen, J.: Inhibition and potentiation of apomorphine-induced hypermotility in rats by neuroleptics. Eur. J. Pharmacol. 36, 385–393 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Carlsson, A.: Receptor mediated control of dopamine metabolism. In: Pre- and post-synaptic receptors. Usdin, E., Bunney, W.E. (eds.), pp. 49–65. New York: Marcel Dekker 1975

    Google Scholar 

  • Cools, A.R., van Rossum, J.M.: Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacologica, functional and clinical data. Psychopharmacologia 45, 243 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Cooper, B.R., Breese, G.R.: Relationship of dopamine neural systems to the behavioral alterations produced by 6-hydroxydopamine administration into brain. In: Neuropsychopharmacology of monoamines and their regulatory enzymes. Usdin, E. (ed.), pp. 353–368. New York: Raven Press 1974

    Google Scholar 

  • Costall, B., Naylor, R.J.: The role of telencephalic dopaminergic systems in the mediation of apomorphine stereotyped behaviour. Eur. J. Pharmacol. 24, 8–24 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Costall, B., Naylor, R.J.: The behavioural effects of dopamine applied intracerebrally to areas of the mesolimbic system. Eur. J. Pharmacol. 32, 87–92 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Costall, B., Naylor, R.J.: Neuroleptic antagonism of dyskinetic phenomena. Eur. J. Pharmacol. 33, 301–312 (1976)

    Article  Google Scholar 

  • Costall, B., Naylor, R.J., Neumeyer, J.L.: Differences in the nature of the stereotyped behaviour indiced by aporphine derivatives in the rat and in their actions in extrapyramidal and mesolimbic brain areas. Eur. J. Pharmacol. 31, 1–16 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Costall, B., Naylor, R.J., Cannon, J.G., Lee, T.: Differentiation of the dopamine mechanisms mediating stereotyped behaviour and hyperactivity in the nucleus accumbens and caudate- putamen. J. Pharm. Pharmacol. 29, 337–342 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Creese, I., Burt, D.R., Snyder, S.H.: Dopamine receptor binding enhancement accompanies lesion induced behavioural supersensitivity. Science 197, 596–598 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Creese, I., Iversen, S.D.: Amphetamine response in rat after dopamine neurone destruction. Nature New Biol. 238, 247–248 (1972)

    PubMed  CAS  Google Scholar 

  • Creese, I., Iversen, S.D.: The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat. Psychpharmacologia 39, 345–357 (1974)

    Article  CAS  Google Scholar 

  • Creese, I., Iversen, S.D.: The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Res. 83, 419–36 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Crow, T.J.: Neurotransmitter-related pathways: the structure and function of central monoamine neurones. In: Biochemical Correlates of Brain Structure and Function. Davison, A.N. (ed.), pp. 137–174. New York: Academic Press 1977

    Google Scholar 

  • Dahlström, A., Fuxe, K.: Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiol. Scand. [Supp.] 232, 1–55 (1964)

    Google Scholar 

  • Divac, I.: Drug-induced syndromes in rats with large, chronic lesions in the corpus striatum. Psychopharmacologia 27, 171–178 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Engel, J., Carlsson, A.: Catecholamines and behavior. Curr. Dev. Psychopharmacol. 4, 1–32 (1977)

    PubMed  CAS  Google Scholar 

  • Ernst, A.M., Smelik, P.G.: Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats. Experientia 66, 837–838 (1966)

    Article  Google Scholar 

  • Evetts, K.D., Uretsky, N.J., Iversen, L.L., Iversen, S.D.: Effects of 6-hydroxy-dopamine on CNS catecholamines, spontaneous motor activity and amphetamine induced hyperactivity in rats. Nature 225, 961–962 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Fibiger, H.C.: Drugs and reinforcement mechanisms: A critical review of the catecholamine theory. Annu. Rev. Pharmacol. Toxicol. 18, 37–56 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Fibiger, H.C., Fibiger, H.P., Zis, A.P.: Attenuation of amphetamine-induced motor stimulation and stereotypy by 6-hydroxydopamine in the rat. Br. J. Pharmacol. 47, 683–692 (1973)

    PubMed  CAS  Google Scholar 

  • Fog, R.L., Randrup, A., Pakkenberg, H.: Aminergic mechanisms in corpus striatum and amphetamine-induced stereotyped behavior. Psychopharmacologia 11, 179–183 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Friedhoff, A. (ed.): Catecholamines and behaviour. Basic Neurobiology. New York, London: Plenum Press 1975 a

    Google Scholar 

  • Friedhoff, A. (ed.): Catecholamines and behaviour. Neuropsychopharmacology. New York, London: Plenum Press 1975 b

    Google Scholar 

  • Fuxe, K.: The position of dopamine among the biogenic amines with neurotransmitter function. Triangle 17, 1–11 (1978)

    CAS  Google Scholar 

  • Hollister, A.S., Breese, G.R., Cooper, B.R.: Comparison of tyrosine hydroxylase and dopamine-hydroxylase inhibition with the effect of various 6-hydroxy-dopamine treatments on amphetamine induced motor activity. Psychopharmacologia 36, 1–16 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hökfelt, T., Ungerstedt, U.: The degeneration pattern of the nigro-neostriatal dopamine system after electrothermic or 6-hydroxy-dopamine lesions. In: Dynamics of degeneration and growth in neurons. Fuxe, K., Olson, L., Zotterman, Y. (eds.), pp. 19–28. Oxford, New York: Pergamon Press 1974

    Google Scholar 

  • Hökfelt, T., Johnsson, O., Fuxe, K., Goldstein, M., Park, D.: Immunohistochemical studies on the localization and distribution of monoamine neuron systems in the rat brain II. Tyrosine hydroxylase in the telencephalon. Med. Biol. 55, 21–40 (1977)

    PubMed  Google Scholar 

  • Iversen, L.L.: Summing up. In: Advances in neurology: dopaminergic mechanisms. Calne, D., Chase, T.N., Barbeau, A. (eds.), pp. 415–418. New York: Raven Press 1975

    Google Scholar 

  • Jackson, D.M., Andén, N.-E., Dahlström, A.: A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain. Psychopharmacologia 45, 139–149 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Kelly, P.H., Seviour, P.W., Iversen, S.D.: Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res. 94, 507–522 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Kebabian, J.W., Clement-Cormier, Y.C., Petzold, G.L., Greengard, P.: Chemistry of dopamine receptors. In: Advances in neurology. Calne, D., Chase, T.N., Barbeau, A. (eds.), pp. 1 - 11. New York: Raven Press 1975

    Google Scholar 

  • Krueger, B.K., Forn, J., Walters, J.R., Roth, R.H., Greengard, P.: Stimulation by dopamine of adenosine cyclic 3’-5’-monophosphate formation in rat caudate nucleus: effect of lesions of the nigrostriatal pathway. Mol. Pharmacol. 12, 639–648 (1976)

    PubMed  CAS  Google Scholar 

  • Langer, S.Z.: The degeneration contraction of the nictitating membrane in the unanesthetized cat. J. Pharmacol. Exp. Ther. 151, 66–72 (1966)

    PubMed  CAS  Google Scholar 

  • Langer, S.Z., Trendelenburg, U.: The onset of denervation supersensitivity. J. Pharmacol. Exp. Ther. 151, 73–86 (1966)

    PubMed  CAS  Google Scholar 

  • Lhermitte, F., Agid, Y., Signoret, J.L., Studier, J.M.: Les dyskinésies de début et fin de dose provoquées par la L-DOPA. Rev. Neurol. (Paris) 133, 297–308 (1977)

    CAS  Google Scholar 

  • Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain. As revealed by the glyoxylic acid fluorescence method. Acta Physiol. Scand. 412, 1–48 (1974)

    CAS  Google Scholar 

  • Lindvall, O., Björklund, A.: Anatomy of the dopaminergic neuron systems in the rat brain. Adv. biochem. psychopharmacol. 19, 1–23 (1978)

    PubMed  CAS  Google Scholar 

  • Ljungberg, T.: Evidence that time related changes in apomorphine stimulation determine the behavioural response. Neuropharmacology (in press) (1979)

    Google Scholar 

  • Ljungberg, T., Ungerstedt, U.: Automatic registration of behaviour related to dopamine and noradrenaline transmission. Eur. J. Pharmacol. 36, 181–188 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Ljungberg, T., Ungerstedt, U.: Different behavioural patterns induced by apomorphine: Evidence that the method of administration determines the behavioural response to the drug. Eur. J. Pharmacol. 46, 41–51 (1977 a)

    Article  PubMed  CAS  Google Scholar 

  • Ljungberg, T., Ungerstedt, U.: Apomorphine-induced locomotion and gnawing: evidence that the experimental design greatly influences gnawing while locomotion remains unchanged. Eur. J. Pharmacol. 46, 147–151 (1977b)

    Article  PubMed  CAS  Google Scholar 

  • Ljungberg, T., Ungerstedt, U.: A method for simultaneous registration of 8 behavioural parameters related to monoamine neurotransmission. Pharmacol. Biochem. Behav. 8, 483–489 (1978 a)

    Article  PubMed  CAS  Google Scholar 

  • Ljungberg, T., Ungerstedt, U.: Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: Evidence for two different mechanisms of action. Psychopharmacology 56, 239–247 (1978 b)

    Article  PubMed  CAS  Google Scholar 

  • McKenzie, G.M.: Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat. Psychopharmacologia 23, 212–219 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.F.: Neurochemistry of Central Monoamine Systems as Related to Food Intake. In: Appertite and food intake: Report of the Dahlem workshop on appertite and food intake, Berlin 1975. Silverstone, T. (ed.), pp. 43–63. Berlin: Dahlem Konferenzen 1976

    Google Scholar 

  • Marshall, J.F., Ungerstedt, U.: Striatal efferent fibers involved in the maintenance of rotational behavior in the rat. Science 198, 62–64 (1977 a)

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.F., Ungerstedt, U.: Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model. Eur. J. Pharmacol. 41, 361–367 (1977 b)

    Article  PubMed  CAS  Google Scholar 

  • Martres, M.P., Costentin, J., Baudry, M., Marcais, H., Protais, P., Schwartz, J.C.: Long-term changes in the sensitivity of pre- and postsynaptic dopamine receptors in mouse striatum as evidenced by behavioural and biochemical studies. Brain Res. 136, 319–337 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Mishra, R.K., Gardner, E.L., Katzman, R., Makman, M.H.: Enhancement of dopamine-stimulated adenylate cyclase activity in rat caudate after lesions in substantia nigra: Evidence for denervation supersensitivity. Proc. Natl. Acad. Sci. USA 71, 3883–3887 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Muenter, M.D., Sharpless, N.S., Tyce, G.M., Darley, F.L.: Patterns of dystonia (“I-D-I” and “D-I-D”) in response to L-DOPA therapy for Parkinson’s disease. Mayo Clin. Proc. 52, 163–174 (1977)

    CAS  Google Scholar 

  • Neill, D.B., Boggan, W.O., Grossman, S.P.: Behavioural effects of amphetamine in rats with lesions in the corpus striatum. J. Comp. Physiol. Psychol. 86, 1019–1030 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Pijnenburg, A J J., van Rossum, J.M.: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens. J. Pharm. Pharmacol. 25, 1003–1004 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Pijnenburg, A.J.J., Honig, W.M.M., Vand der Heyden, J.A.M., van Rossum, J. M.: Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity. Eur. J. Pharmacol. 35, 45–58 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Price, M.T., Fibiger, H.C: Apomorphine and amphetamine stereotypy after 6-hydroxydopamine lesions of the substantia nigra. Eur. J. Pharmacol. 29, 249–252 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Puech, A.J., Simon, P., Chermat, R., Boissier, J.-R.: Profil neuropsychopharmacologique de L’Apomorphine. J. Pharmacol. 5, 241–254 (1974)

    CAS  Google Scholar 

  • Puech, A.J., Simon, P., Boissier, J.-R.: Antagonism by sulpiride of three apomorphine-induced effects in rodents. Eur. J. Pharmacol. 36, 4391–4341 (1976)

    Article  Google Scholar 

  • Randrup, A., Munkvad, I.: Role of catecholamines in the amphetamine excitatory response. Nature 211, 540 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Randrup, A., Munkvad, I.: Biochemical, anatomical and psychological investigations of stereotyped behavior induced by amphetamine. In: Amphetamine and related compounds. Proceedings of the Mario Negri Institute for Pharmacological Research, Milan, Italy. Costa, E., Garattini, S. (eds.), pp. 695–713. New York: Raven Press 1970

    Google Scholar 

  • Roberts, D.C.S., Ziz, A.P., Fibiger, H.C.: Ascending catecholamine pathways and amphet- amine-induced locomotor activity: Importance of dopamine and apparent non-involvement of norepinephrine. Brain Res. 93, 441–454 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Scheel-Kriiger, J., Randrup, A.: Stereotype hyperactive behaviour produced by dopamine in the absence of noradrenaline. Life Sci. 6, 1389–1398 (1967)

    Article  Google Scholar 

  • Schultz, W., Ungerstedt, U.: Striatal cell supersensitivity to apomorphine in dopamine lesioned rats correlated to behaviour. Neuropharmacology (in press) (1979)

    Google Scholar 

  • Schwartz, J.C., Costentin, J., Martres, M.P., Protais, P., Bandry, M.: Modulation of receptor mechanisms in the CNS: Hyper- and hyposensitivity to catecholamines. Neuropharmacology 77, 665–685 (1978)

    Article  Google Scholar 

  • Seiden, S.L., Dykstra, A.L.: Pychopharmacology. A biochemical and behavioral approach. New York: Van Nostrand Reinhold 1977

    Google Scholar 

  • Strieker, E.M., Zigmond, J.: Recovery of function after damage to central catecholamine-containing neurons: A neurochemical model for the lateral hypothalamic syndrome. Prog. Psychobiol. Physiol. Psychol. 6, 121–187 (1976)

    Google Scholar 

  • Strömberg, U., Svensson, T.H.: L-DOPA induced effects on motor activity in mice after inhibition of dopamine-hydroxylase. Psychopharmacologia 19, 53–60 (1971)

    Article  PubMed  Google Scholar 

  • Strömbom, U.: Catecholamine receptor agonists: Effects on motor activity and rate of tyrosine hydroxylation in mouse brain. Naunyn-Schmiedeberg’s Arch. Pharmacol. 292, 167–176 (1976)

    Google Scholar 

  • Svensson, T.H.: The effect of inhibition of catecholamine synthesis on dexamphetamine in-duced central stimulation. Eur. J. Pharmacol. 12, 161–166 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Svensson, T.H., Waldeck, B.: On the significance of central noradrenaline for motor activity: Experiments with a new dopamine hydroxylase inhibitor. Eur. J. Pharmacol. 7, 278–282 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Svensson, T.H., Waldeck, B.: On the role of brain catecholamines in motor activity: Experiments with inhibitors of synthesis and of monoamine oxidase. Psychopharmacologia 18, 357–365 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Ungerstedt, U.: 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur. J. Pharmacol. 5, 107–110 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand. [Suppl.] 367, 1–48 (1971a)

    CAS  Google Scholar 

  • Ungerstedt, U.: Histochemical studies on the effects of intracerebral and intraventricular injections of 6-hydrozydopamine on monoamine neurons in the rat brain. In: 6-Hydrozydopa- mine and catecholamine neurons. Malmfors, T., Thoenen, H. (eds.), pp. 101–127. Amsterdam, London: North-Holland 1971b

    Google Scholar 

  • Ungerstedt, U.: Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta Physiol. Scand. [Suppl.] 367, 49–68 (1971c)

    CAS  Google Scholar 

  • Ungerstedt, U.: Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol. Scand. [Suppl.] 367, 69–93 (1971 d)

    CAS  Google Scholar 

  • Ungerstedt, U.: Brain dopamine neurons and behaviour. In: The neurosciences. Schmitt, F.O., Worden, F.G. (eds.), pp. 695–711. Cambridge, London: MIT Press 1974a

    Google Scholar 

  • Ungerstedt, U.: Functional dynamics of central monoamine pathways. In: The neurosciences: Third study program. Schmitt, F.O., Worden, F.G. (eds.), pp. 979–988. Cambridge, London: MIT Press 1974 b

    Google Scholar 

  • Ungerstedt, U.: Central dopamine mechanisms and unconditioned behaviour. In: The neurology of dopamine. Horn, A.S. (ed.). London: Academic Press 1979

    Google Scholar 

  • Ungerstedt, U., Arbuthnott, G.: Quantitative recording of rotational behaviour in rats after 6- hydroxy-dopamine lesions of the nigro-striatal dopamine system. Brain Res. 24, 485–493 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Ungerstedt, U., Ljungberg, T.: Behavioural patterns related to dopamine neurotransmission: Effect of acute and chronic antipsychotic drugs. Adv. Biochem. Psychopharmacol. 16„ 193–199 (1977)

    Google Scholar 

  • Ungerstedt, U., Ljungberg, T., Ranje, C.: Dopamine neurotransmission and the control of behaviour. In: Psychobiology of the striatum, van Rossum, J.M., Cools, A. (eds.), pp. 85–97. Amsterdam, New York, Oxford: North-Holland 1977

    Google Scholar 

  • Ungerstedt, U., Ljungberg, T., Schultz, W.: Dopamine receptor mechanisms: behavioural and electrophysiological studies. Adv. Biochem. Psychopharmacol. 19, 311–321 (1978)

    PubMed  CAS  Google Scholar 

  • Von Voigtlander, P.F., Boukma, S.J., Johnson, G.A.: Dopaminergic denervation supersensitivity and dopamine-stimulated adenyl cyclase activity. Neuropharmacology 12, 1081–1086 (1973)

    Article  Google Scholar 

  • Wolfarth, S.: Reactions to apomorphine and spiroperidol of rats with striatal lesions: the relevance of kind and size of the lesion. Pharmacol. Biochem. Behav. 2, 181–186 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Wolfarth, S., Grabowska, M., Lacki, M., Dulska, E., Antkiewicz, L.: The action of apomorphine in rats with striatal lesions. Activitas Nervosa Superior 15, 132 (1973)

    PubMed  CAS  Google Scholar 

  • Yehuda, S., Wurtman, R.J.: Dopaminergic neurons in the nigrostriatal and mesolimbic pathways: Mediation of specific effects of d-amphetamine. Eur. J. Pharmacol. 30, 154–158 (1975)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. U. Ungerstedt
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University Medical School of Szeged, Dóm tér 12, H-6701, Szeged, Hungary

    Lászlo Szekeres

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ungerstedt, U. (1980). Behavioural Pharmacology Reflecting Catecholamine Neurotransmission. In: Szekeres, L. (eds) Adrenergic Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 54 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67505-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67505-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67507-2

  • Online ISBN: 978-3-642-67505-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation