Mechanism of Damage to the Stem Cell Population

  • R. Schofield
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 24)


Bone marrow aplasia will be recognised clinically at any time there is a failure to produce mature cells or their recognisable precursors. This situation could conceivably arise in a number of ways: (a) failure to induce differentiation of committed precursor cells (eg. erythropoietin-responsive cells) or destruction of that population; (b) failure of the earliest committed precursor cells (e.g. erythroid burst-forming cells) to proliferate or loss of these cells; (c) failure of differentiation from the pluripotent stem cell; (d) total lack of haemopoietic stem cells.


Stem Cell Stem Cell Population Stem Cell Niche Irradiate Mouse Serial Transplantation 
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© Springer-Verlag Berlin Heidelberg 1979

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  • R. Schofield

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