Advertisement

The Contribution of in Vitro Cultures to the Elucidation of the Pathogenesis of Aplastic Anaemia

  • H. L. Haak
  • H. M. Goselink
  • L. Sabbe
  • W. F. J. Veenhof
  • A. J. J. C. Bogers
  • J. L. M. Waayer
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 24)

Abstract

In this paper we shall consider aplastic anaemia (AA) as the syndrome, characterized by pancytopenia and a hypocellular bone marrow, without evidence of malignancy, metabolic disease or cytostatic treatment.

Keywords

Aplastic Anaemia Paroxysmal Nocturnal Hemoglobinuria Lymphocyte Subpopulation Mixed Lymphocyte Reaction Hemopoietic Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ascensao, J., Kagan, W., Moore, M., Pahwa, R., Hansen, J., Good, R.: Aplastic anaemia: Evidence for an immunological mechanism. The Lancet 27, 669–671 (1976)CrossRefGoogle Scholar
  2. 2.
    Barr, R. D., Whang-Peng, J., Perry, S.: Regulation of human hemopoietic stem cell proliferation by syngeneic thymus-derived lymphocytes. Acta Haemat. 58, 74–78 (1977)PubMedCrossRefGoogle Scholar
  3. 3.
    Deeg, H. J., Storb, R., Weiden, P. L., Torok-Storb, B., Graham, T., Thomas, E. D.: Resistance to marrow grafts in dogs mediated by antigens close to but not identical with DLA-A, B and D and overcome by infusion of thoracic duct lymphocytes. Exp. Hemat. 6, 23 (1978)Google Scholar
  4. 4.
    Frindel, E., Croizat, H.: The relationship between CFU kinetics and the thymus. Annals of New York Academy of Sciences 249, 468–476 (1975)CrossRefGoogle Scholar
  5. 5.
    Goodman, J. W., Basford, N. L., Shinpock, S. G., Chambers, Z. E.: An amplifier cell in hemopoiesis. Exp. Hemat. 6, 151–160 (1978)PubMedGoogle Scholar
  6. 6.
    Haak, H. L., Goselink, H. M., Veenhof, W., Pellinkhof-Stadelmann, S., Kleiverda, J. K., te Velde, J.: Acquired aplastic anaemia in adults. IV. Histological and CFU studies in transplanted and non-transplanted patients. Scand. J. of Haemat. 19, 159–171 (1977)CrossRefGoogle Scholar
  7. 7.
    Hoffman, R., Esmail, D. Z., Lutton, J. D., Zalusky, R., Wasserman, L. R.: Suppression of erythroid-colony formation by lymphocytes from patients with aplastic anaemia. New Engl. J. of Med. 6, 10–13 (1977)CrossRefGoogle Scholar
  8. 8.
    Iscove, N. N., Senn, J. S., Till, J. E., McCulloch, E. A.: Colony formation by normal and leukemic human marrow cells in culture: Effect of conditioned medium from human leukocytes. Blood 37, 1–5 (1971)PubMedGoogle Scholar
  9. 9.
    Kagan, W. A., Ascensao, J. A., Pahwa, R. N., Hansen, J. A., Goldstein, G., Valera, E. B., Incefy, G. S., Moore, M. A. S., Good, R. A.: Aplastic anemia: Presence in human bone marrow of cells that suppress myeolopoiesis. Proceedings of National Academy Science 73, 2890–2894 (1976)CrossRefGoogle Scholar
  10. 10.
    Lau, L., McCulloch, E. A., Till, J. E., Price, G. B.: The production of hemopoietic growth factors by PHA-stimulated leukocytes. Exp. Hemat. 6, 114–121 (1978)PubMedGoogle Scholar
  11. 11.
    Lord, B. I., Schofield, R.: The influence of thymus cells in hemopoiesis: Stimulation of hemopoietic stem cells in a syngeneic in vivo situation. Blood 42, 395–404 (1973)PubMedGoogle Scholar
  12. 12.
    Moretta, L., Webb, S. R., Grossi, C. E., Lydyard, P. M., Cooper, M. D.: Functional analysis of two human T-cells subpopulations: Help and suppression of B-cell responses by T-cells bearing receptors for IgM or IgG. J. of Exp. Med. 146, 184–200 (1977)CrossRefGoogle Scholar
  13. 13.
    Nathan, D. G., Chess, L., Hillman, D. G., Clarke, B., Breard, J., Merler, E., Housman, D. E.; Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro. J. of Exp. Med. 147, 324–339 (1978)CrossRefGoogle Scholar
  14. 15.
    Van Oers, M. H. J., Zeijlemaker, W. P.: The mixed lymphocyte reaction (MLR) stimulatory EA-rosette forming lymphocytes in humans. Europ. J. of Immunol. 7, 143–150 (1977)CrossRefGoogle Scholar
  15. 15.
    Van Oers, M. H. J., Zeijlemaker, W. P.: The mixad lymphocyte reaction (MLR) stimulatory capacity of human lymphocyte subpopulations. Cellular Immunology 31, 205–215 (1977)PubMedCrossRefGoogle Scholar
  16. 16.
    Pritchard, L. L., Goodman, J. W.: Dose-dependence of the augmentation of hemopoiesis by thymocytes. Exp. Hemat. 6, 161–171 (1978)PubMedGoogle Scholar
  17. 17.
    Resnitzky, P., Zipori, D., Trainin, N.: Effect of neonatal thymectomy of hemopoietic tissue in mice. Blood 37, 634–646 (1971)PubMedGoogle Scholar
  18. 18.
    Sakane, T., Green, I.: Human suppressor T-cells induced by concanavalin a: Suppressor T-cells belong to distinctive T-cell subclasses. J. of Immunol. 119, 1169–1178 (1977)Google Scholar
  19. 19.
    Shah, R. G., Caporale, L. H., Moore, A. S.: Characterization of colony-stimulating activity produced by human monocytes and phytohemagglutinin-stimulated lymphocytes. Blood 50, 811–821 (1977)PubMedGoogle Scholar
  20. 20.
    Shou, L., Schwartz, S. A., Good, R. A.: Suppressor cell activity after concanavalin a treatment of lymphocytes from normal donors. J. of Exp. Med. 143, 1100–1110 (1976)CrossRefGoogle Scholar
  21. 21.
    Singer, J. W., Brown, J. E., James, M. C., Doney, K., Warren, R. P., Storb, R., Thomas, E. D.: The effect of peripheral blood lymphocytes from patients with aplastic anemia on granulocytic colony growth from H. L. A. matched and mismatched marrows: the effect of transfusion sensitization. Blood 52, 37–46 (1978)PubMedGoogle Scholar
  22. 22.
    Storb, R.: Personal communication (1978)Google Scholar
  23. 23.
    Speck, B., Gluckman, E., Haak, H. L., van Rood, J. J.: Treatment of aplastic anaemia by antilymphocyte globulin with or without marrow infusion. Clin. Hematol. 7, 611–621 (1978)Google Scholar
  24. 24.
    te Velde, J., Haak, H. L.: Acquired aplastic anaemia in adults: Histological investigation of methacrylate embedded bone marrow biopsy specimens. Correlation with survival after conventional treatment in 15 adults patients. Brit. J. of Hematol. 35, 61–69 (1977)CrossRefGoogle Scholar
  25. 25.
    Wiktor-Jedrzejczak, W., Ahmed, A., Sharkis, S. J. and Sell, K. W.: Surface phenotype and other properties of a theta-sensitive cell which regulates hematopoiesis. Exp. Hematol. 6, (Suppl. 3) 40 (1978)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • H. L. Haak
  • H. M. Goselink
  • L. Sabbe
  • W. F. J. Veenhof
  • A. J. J. C. Bogers
  • J. L. M. Waayer

There are no affiliations available

Personalised recommendations