The Role of Haplo-Identical Bone Marrow Transfusion in ALG Treated Patients with Severe Aplastic Anemia (SAA)

  • W. Weber
  • B. Speck
  • P. Cornu
  • C. Nissen
  • M. Jeannet
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 24)


Immunosuppression with ALG has become a new alternative in the treatment of SAA [19]. In the original reports ALG was followed by a BM infusion from a family donor [12, 15]. In subsequent experimental and clinical trials ALG has been effective with and without BM infusion [16, 17, 19, 20, 21]. This modality is applicable in the HLA-nonidentical setting; it is not followed by GvHD and leads to autologous BM recovery in more than 50% of patients with SAA. It is still an unsolved problem whether ALG followed by BM is more or less effective than ALG alone.


Aplastic Anemia Total Body Irradiation Severe Aplastic Anemia Aplastic Anemia Patient Family Donor 
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© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • W. Weber
  • B. Speck
  • P. Cornu
  • C. Nissen
  • M. Jeannet

There are no affiliations available

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