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The Value of In Vitro Culture in Diagnosis and Progress in Preleukemia and Oligoblastic Leukemia

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Preleukemia

Abstract

The in vitro assay of Robinson has been used in preleukemia to determine the prognosis of the individual patient. Five in vitro patterns could be identified of which one category had a definitely better prognosis. The same patterns were holding for oligoblastic leukemia and it appeared that in th patients without leukemic in vitro growth patterns the rapidity of progression into acute leukemia was much slower than in patients with the leukemic in vitro patterns.

Supported in part by Grants CA-11520, CA-15528 and CA-19586 from NIH, Bethesda, Maryland.

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References

  1. Pike, B.L., Robinson, W.A.: Human bone marrow colony growth in agar gel. J. of. Cell Physiol. 76, 77–84(1970)

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  2. Spitzer, G., Dicke, K.A., Gehan, E.A., Smith, T., McCredie, K.B., Barlogie, B., Freireich, E.J.: A simplified in vitro classification for prognosis in adult acute leukemia. In: The application of I.V. results in remission predictive models. Blood 48, 795–807 (1976)

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  3. Spitzer, G., Dicke, K.A., Verma, D.S., McDredie, K.B.: Subgroups of oligoleukemia as identified by in vitro agar culture. Leukemia Res. 3, 29–39 (1979)

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  4. Verma, D.S., Spitzer, G., Dicke, K.A., McCredie, K.B.: In vitro agar culture patterns in pre-leukemia and their clinical significance. Leukemia Res. 3, 41–49 (1979)

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Authors
  1. K. A. Dicke
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  2. G. Spitzer
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  3. D. S. Verma
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Editor information

Editors and Affiliations

  1. Universitätsklinik für Innere Medizin Innsbruck, A-6020, Innsbruck, Austria

    Franz Schmalzl

  2. Medizinische Universitätsklinik Köln, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Germany

    Klaus-Peter Hellriegel

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© 1979 Springer-Verlag Berlin Heidelberg

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Dicke, K.A., Spitzer, G., Verma, D.S. (1979). The Value of In Vitro Culture in Diagnosis and Progress in Preleukemia and Oligoblastic Leukemia. In: Schmalzl, F., Hellriegel, KP. (eds) Preleukemia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67470-9_21

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  • DOI: https://doi.org/10.1007/978-3-642-67470-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09698-6

  • Online ISBN: 978-3-642-67470-9

  • eBook Packages: Springer Book Archive

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