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Pharmacology of Ganglionic Transmission pp 267–279Cite as

Absorption, Distribution, Fate, and Excretion of Ganglion-Blocking Compounds

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 53)

Abstract

It has been said of the ganglion-blocking drugs that “many of the features of absorption, distribution and excretion of these drugs are predictable from a knowledge of their physical and chemical properties” (Dollery, 1964). While this may be true as a generalisation, there are still aspects that are incompletely understood. The non-depolarising ganglion-blocking compounds are divisible into two groups according to their physical and chemical properties and the major characteristics of their absorption, etc. Within each group the responses are essentially similar. The first is the onium group, which includes tetraethylammonium, hexamethonium, pendiomid, pentolinium, chlorisondamine and trimethaphan. These are compounds that are completely ionised in aqueous solution. The second group is represented by the secondary amine mecamylamine and the tertiary amine pempidine. Although this group of compounds all have high pKa values, so that at physiological pH they are very largely ionised, there is still some un-ionized compound present in aqueous solution.

Keywords

  • Choroid Plexus
  • Hypotensive Effect
  • Superior Cervical Ganglion
  • Quaternary Ammonium Compound
  • Hypotensive Action

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  1. D. F. J. Mason
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  1. Department of Pharmacology, First Medical Institute, 2/6, B. Pirogovskaja St., 119435, Moscow, USSR

    Professor Dr. Dimitry A. Kharkevich

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Mason, D.F.J. (1980). Absorption, Distribution, Fate, and Excretion of Ganglion-Blocking Compounds. In: Kharkevich, D.A. (eds) Pharmacology of Ganglionic Transmission. Handbook of Experimental Pharmacology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67397-9_10

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