Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID)
There have been successful instances of reconstitution of patients with severe combined immunodeficiencies (SCID) after transplantation of bone marrow, fetal tissue, and, more recently, cultured thymic epithelium [1, 2, 3, 12]. This report summarizes 15 attempts made in our group to correct various types of SCID by grafts of fetal liver and/or thymic cells, or by transplantation of phenotypically or genotypically identical bone marrow tissue. Special emphasis will be given to the complete immunological reconstitution after compatible bone marrow cell transplantation, of SCID patients showing a normal number of B lymphocytes before transplantation. These patients, who appear to have a defect of precursor T cells, were reconstituted by donor marrow stem cells that were able to mature into the host thymus environment, and to become capable of expressing cell-mediated functions and of cooperating with recipient B cells in antibody production.
KeywordsBone Marrow Transplantation Graft Versus Host Disease Fetal Tissue Severe Combine Immunodeficiency Severe Combine Immunodeficiency Disease
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