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Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID)

  • C. Griscelli
  • A. Durandy
  • J. L. Virelizier
  • D. Buriot
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 25)

Abstract

There have been successful instances of reconstitution of patients with severe combined immunodeficiencies (SCID) after transplantation of bone marrow, fetal tissue, and, more recently, cultured thymic epithelium [1, 2, 3, 12]. This report summarizes 15 attempts made in our group to correct various types of SCID by grafts of fetal liver and/or thymic cells, or by transplantation of phenotypically or genotypically identical bone marrow tissue. Special emphasis will be given to the complete immunological reconstitution after compatible bone marrow cell transplantation, of SCID patients showing a normal number of B lymphocytes before transplantation. These patients, who appear to have a defect of precursor T cells, were reconstituted by donor marrow stem cells that were able to mature into the host thymus environment, and to become capable of expressing cell-mediated functions and of cooperating with recipient B cells in antibody production.

Keywords

Bone Marrow Transplantation Graft Versus Host Disease Fetal Tissue Severe Combine Immunodeficiency Severe Combine Immunodeficiency Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Amman, A. J., Wara, D. W., Salmon, S., Perkins, H.: Thymus transplantation. Permanent reconstitution of cellular immunity in a patient with sex-linked combined immunodeficiency. N. Eng. J. Med. 5, 5 (1973)CrossRefGoogle Scholar
  2. 2.
    Buckley, R. H.: Reconstitution: grafting of bone marrow and thymus. In: Amo D. B. (Ed.): Progress in Immunology, p. 1061. New York: Academic Press 1971Google Scholar
  3. 3.
    Buckley, R. H., Whismant, J. K., Schiff, R. I., Gilbersten, R. B., Huang, A. T., Platt, M. S.: Correction of severe combined immunodeficiency by fetal liver cells. N. Eng. J. Med. 294, 1076 (1976)CrossRefGoogle Scholar
  4. 4.
    Capersson, T., Zech, L., Johansson, C., Modest, E. J.: Identification of human chromosomes by DNA binding fluorescent agents. Chromosoma 30, 215 (1970)Google Scholar
  5. 5.
    De Fazio, S., Criswell, B. S., Kimzey, S. L., South, M. A., Montgomery, J. R.: A paraprotein in severe combined immunodeficiency disease detected by immunoelectrophoresis analysis of plasma. Clin. Exp. Immunol. 19, 563 (1975)PubMedGoogle Scholar
  6. 6.
    Dooren, L. J., Kamphuis, R. P., De Koning, J., Vossen, J. M.: Bone marrow transplantation in children. Semin. Hematol. 11, 369 (1974)PubMedGoogle Scholar
  7. 7.
    Geha, R. S., Schneeberger, E., Gatien, J., Rosen, F. S.: Synthesis of an M-component by circulating B lymphocytes in severe combined immunodeficiency. N. Eng. J. Med. 290, 726 (1974)CrossRefGoogle Scholar
  8. 8.
    Good, R. A., Bach, F. H.: Bone marrow and thymus transplants: Cellular engineering to correct primary immunodeficiency. In: Bach, F. H., Good, R. A. (Eds.): Clinical Immunobiology, Vol. 2, p. 63. New York: Academic Press 1974Google Scholar
  9. 9.
    Griscelli, C.: T and B markers in immunodeficiencies. In: Bergsma, D. (Ed.): Birth Defects: Immunodeficiency in Man and Animals, Vol. 11, p. 45. New York: The National Foundation March of Dimes 1975Google Scholar
  10. 10.
    Griscelli, C.: Bone marrow transplantation in SCID. In: Bergsma, E. (Ed.): Birth Defects: Immunodeficiency in Man and Animals, Vol. 11, p. 426. New York: The National Foundation March of Dimes 1975Google Scholar
  11. 11.
    Griscelli, C., Durandy, A., Virelizier, J. L., Ballet, J. J., Daguillard, F.: Selective defect of precursor T cells in severe combined immunodeficiency with B lymphocytes. J. Pediatr. 93, 404–411 (1978)PubMedCrossRefGoogle Scholar
  12. 12.
    Hong, R., Santosham, M., Schulte-Wissermann, H., Horowitz, S., Hsu, S. F., Winkelstein, J. A.: Reconstitution of B and T lymphocyte functions in severe combined immunodeficiency disease after transplantation with thymic epithelium. Lancet II, 1270 (1976)CrossRefGoogle Scholar
  13. 13.
    Incefy, G. S., Dardenne, M., Pahwa, S., Grimes, E., Pahwa, R., Smithwick, E., O’reilly, R., Good, R. A.: Thymic activity in severe combined immunodeficiency disease. Proc. Natl. Acad. Sci. USA Vol. 74, 1250–1253, March 7, Medical Sciences (1978)CrossRefGoogle Scholar
  14. 14.
    Keightley, R. G., Lawton, A. R., Cooper, M. D., Ynis, E. J.: Successful fetal liver transplantation in a child with severe combined immunodeficiency. Lancet II, 850 (1975)CrossRefGoogle Scholar
  15. 15.
    Pyke, K. W., Dosch, H. M., Ipp, M. M., Gelfand, E. W.: Demonstration of an intrathymic defect in a case of severe combined immunodeficiency disease. N. Eng. J. Med. 293, 424 (1975)CrossRefGoogle Scholar
  16. 16.
    Rachelefsky, G. S., Stiehm, E. R., Amman, A. J., Cederbaum, S. D., Opelz, G., Terasaki, P. I.: T cell reconstitution by thymus transplantation and transfer fact in severe combined immunodeficiency. Pediatr. 55, 114 (1975)Google Scholar
  17. 17.
    Seeger, R. C., Robins, R. A., Stevens, R. H., Klein, R. B., Waldman, D. J., Zeltzer, P. M., Kessler, S. W.: Severe combined immunodeficiency with B lymphocytes: In vitro correction of defective Ig production by addition of normal T lymphocytes. Clin. Exp. Immunol. 26, 1 (1976)PubMedGoogle Scholar
  18. 18.
    Virelizier, J. L., Durandy, A., Ballet, J. J., Griscelli, C.: Immunological dysregulation after bone marrow transplantation in patients with severe combined immunodeficiency. Pathol. Biol. (Paris) 26, 21–22 (1978)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • C. Griscelli
  • A. Durandy
  • J. L. Virelizier
  • D. Buriot

There are no affiliations available

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