Abstract
Since the existence of hemopoietic stem cells has been proved experimentally and these cells together with their descendants were found to spread within the hemopoietic system and to form colonies in hemopoietic organs [24], another challenging problem came to light, i.e. the problem of differentiation factors in hemopoiesis. The development of hemopoietic cells is believed to be regulated by local differentiation factors distributed among various hemopoietic organs. They produce a short-distance effect upon hemopoietic cells which largely accounts for different cellular content in various hemopoietic organs. The effect of local differentiation factors is manifested, in particular, during formation of hemopoietic colonies in irradiated recipient-mice. A typical feature of the colonies is high homogeneity of their cellular content as compared to the normal hemopoietic tissue [24]. Morphologically discernible cells of essentially the same type are found in the colonies by the 7–10th day. At the same time the colonies are shown to have polypotent stem cells and committed precursors for all the three types of hemopoiesis, as well as B cell precursors [15, 21]. Hence, for example, the development of myeloid precursors (regardless of the degree of their committment) is inhibited while they are still included in the erythroid colonies whereas the development of erythroid precursors is suppressed in the myeloid colonies.
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Friedenstein, A.J. (1980). Stromal Mechanisms of Bone Marrow: Cloning in Vitro and Retransplantation in Vivo. In: Thierfelder, S., Rodt, H., Kolb, H.J. (eds) Immunobiology of Bone Marrow Transplantation. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67319-1_3
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DOI: https://doi.org/10.1007/978-3-642-67319-1_3
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