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Cellular Hypersensitivity and Inflammation

  • Conference paper
Inflammatory Reaction

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 68))

Abstract

Cellular hypersensitivity (cell-mediated immunity) is an immunologic reaction that is dependent upon the activity of sensitized lymphocytes rather than specific immunoglobulin. In most cases the lymphocytes do not act directly as effectors, but elaborate soluble products which are known as lymphokines. The classic example of a cell-mediated immune reaction is that of “delayed hypersensitivity,” which is the cutaneous manifestation of this form of response. It is also referred to, especially in the older literature, as “tuberculin” type hypersensitivity. The delayed reaction is a slowly evolving inflammatory reaction (24–48 h to reach maximal size) which develops at the site of injection of antigen into a previously sensitized individual. It appears grossly as an indurated lump and microscopically, at least in man and the guinea pig, as a collection of lymphocytes and macrophages which are usually collectively referred to as “mononuclear” cells. The delayed hypersensitivity reaction can be transferred to a normal, nonimmune individual by sensitized lymphocytes, but not by serum.

Some of the work described here was supported by N.I.H. grants AI 12477, AI 12225, AI 13258 and HL 19711.

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Authors
  1. Marion C. Cohen
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  2. Stanley Cohen
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Editors and Affiliations

  1. Division of Experimental Pathology, Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada, M5S 1A8

    H. Z. Movat (Professor Dr.) (Professor Dr.)

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Cohen, M.C., Cohen, S. (1979). Cellular Hypersensitivity and Inflammation. In: Movat, H.Z. (eds) Inflammatory Reaction. Current Topics in Pathology, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67311-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-67311-5_9

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