Cerebral Circulatory Changes in Normal Aging and Dementia

  • W. D. Obrist
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 7)


Cerebral blood flow (CBF) undergoes a decline with aging, the magnitude of which is a function of health status. Reductions in CBF are correlated with intellectual deterioration and are paralleled by decreases in cerebral metabolic rate. The present paper describes these CBF changes, both in normal senescence and in the dementias of old age.


Cerebral Blood Flow Mean Arterial Blood Pressure Regional Cerebral Blood Flow Cerebral Metabolic Rate Cerebral Blood Flow Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Baer, P.E., Faibish, G.M., Meyer, J.S., Mathew, N.T., Rivera, V.M.: Neuropsychological correlates of hemispheric and regional cerebral blood flow in dementia. In: Cerebral vascular disease: 7th International Conference Salzburg. Meyer, J.S., Lechner, H., Reivich, M. (eds.), pp. 100–106. Stuttgart: Thieme 1976Google Scholar
  2. Barron, S.A., Jacobs, L., Kinkel, W.R.: Changes in size of normal lateral ventricles during aging determined by computerized tomography. Neurology 26, 1011–1013 (1976)PubMedGoogle Scholar
  3. Bentsen, N., Larsen, B., Lassen, N.: Chronically impaired autoregulation of cerebral blood flow in long-term diabetics. Stroke 6, 497–502 (1975)PubMedCrossRefGoogle Scholar
  4. Brody, H.: Structural changes in the aging nervous system. Interdisciplinary Topics Gerontol. 7, 9–21 (1970)Google Scholar
  5. Dastur, D.K., Lane, M.H., Hansen, D.B., Kety, S.S., Butler, R.N., Perlin, S., Sokoloff, L.: Effects of aging on cerebral circulation and metabolism in man. In: Human aging: A biological and behavioral study. PHS Publication No. 986, pp. 57–76. Washington, D.C.: U.S. Government Printing Office 1963Google Scholar
  6. Dekoninch, W.J., Collard, M., Jacquy, J.: Comparative study of cerebral vasoactivity in vascular sclerosis of the brain in elderly men. Stroke 6, 673–677 (1975)CrossRefGoogle Scholar
  7. Finnerty, F.A., Witkin, L., Fazekas, J.F.: Cerebral hemodynamics during cerebral ischemia induced by acute hypotension. J. Clin. Invest. 33, 1227–1232 (1954)PubMedCrossRefGoogle Scholar
  8. Freyhan, F.A., Woodford, R.B., Kety, S.S.: Cerebral blood flow and metabolism in psychoses of senility. J. Nerv. Ment. Dis. 113, 449–456 (1951)PubMedGoogle Scholar
  9. Géraud, J., Bes, A., Delpla, M., Marc-Vergnes, J.P.: Cerebral arteriovenous oxygen differences: Reappraisal of their significance for evaluation of brain function. In: Research on the cerebral circulation. Meyer, J.S., Lechner, H., Eichhorn, O. (eds.), pp. 209–222. Springfield, Ill.: Thomas 1969Google Scholar
  10. Hachinski, V.C., Lassen, N.A., Marshall, J.: Multi-infarct dementia: A cause of mental deterioration in the elderly. Lancet 2, 207–210 (1974)PubMedCrossRefGoogle Scholar
  11. Hachinski, V.C., Iliff, L.D., Zilhka, E., DuBoulay, G.H., McAllister, V.L., Marshall, J., Russell, R.W.R., Symon, L.: Cerebral blood flow in dementia. Arch. Neurol. 32, 632–637 (1975)PubMedGoogle Scholar
  12. Hedlund, S., Köhler, V., Nylin, G., Olsson, R., Regnström, O., Rothström, E., Åström, K.E.: Cerebral blood circulation in dementia. Acta Psychiatr. Scand. 40, 77–106 (1964)PubMedCrossRefGoogle Scholar
  13. Heyman, A., Patterson, J.L., Duke, T.W., Battey, L.L.: The cerebral circulation and metabolism in arteriosclerotic and hypertensive cerebrovascular disease. N. Engl. J. Med. 249, 223–229 (1953)PubMedCrossRefGoogle Scholar
  14. Ingvar, D.H., Gustafson, L.: Regional cerebral blood flow in organic dementia with early onset. Acta Neurol. Scand. 43, 42–73 (1970)Google Scholar
  15. Kety, S.S.: Human cerebral blood flow and oxygen consumption as related to aging. Res. Publ. Assoc. Nerv. Ment. Dis. 35, 31–45 (1956)Google Scholar
  16. Lassen, N.A., Munck, O., Tottey, E.R.: Mental function and cerebral oxygen consumption in organic dementia. Arch. Neurol. Psychiatr. 77, 126–133 (1957)Google Scholar
  17. Lassen, N.A., Feinberg, I., Lane, M.H.: Bilateral studies of cerbral oxygen uptake in young and aged normal subjects and in patients with organic dementia. J. Clin. Invest. 39, 491–500 (1960)PubMedCrossRefGoogle Scholar
  18. Lavy, S., Melamed, E., Bentin, S., Cooper, G., Rinot, Y.: Bihemispheric decreases of regional blood flow in dementia: Correlation with age-matched normal controls. Ann. Neurol. 4, 445–450 (1978)PubMedCrossRefGoogle Scholar
  19. Novack, P., Shenkin, H.A., Bortin, L., Goluboff, B., Soffe, A.M.: The effects of carbon dioxide inhalation upon the cerebral blood flow and cerebral oxygen consumption in vascular disease. J. Clin. Invest. 32, 696–702 (1953)PubMedCrossRefGoogle Scholar
  20. O’Brien, M.D., Mallett, B.L.: Cerebral cortex perfusion rates in dementia. J. Neurol. Neurosurg. Psychiatry 33, 497–500 (1970)PubMedCrossRefGoogle Scholar
  21. Obrist, W.D., Chivian, E., Cronquvist, S., Ingvar, D.H.: Regional cerebral blood flow in senile and presenile dementia. Neurology 20, 315–322 (1970)PubMedGoogle Scholar
  22. Obrist, W.D., Thompson, H.K., Jr., Wang, H.S., Wilkinson, W.E.: Regional cerebral blood flow estimated by 133xenon inhalation. Stroke 6, 245–256 (1975)PubMedCrossRefGoogle Scholar
  23. Scheibel, M.E., Lindsay, R.D., Tomiyasu, U., Scheibel, A.B.: Progressive dendritic changes in aging human cortex. Exp. Neurol. 47, 392–403 (1975)PubMedCrossRefGoogle Scholar
  24. Scheinberg, P.: Cerebral blood flow in vascular disease of the brain. Am. J. Med. 8, 139–147 (1950)PubMedCrossRefGoogle Scholar
  25. Schieve, J.F., Wilson, W.P.: The influence of age, anesthesia and cerebral arteriosclerosis on cerebral vascular activity to CO2. Am. J. Med. 15, 171–174 (1953)PubMedCrossRefGoogle Scholar
  26. Simard, D., Olesen, J., Paulson, O.B., Lassen, N.A., Skinhøj, E.: Regional cerebral blood flow and its regulation in dementia. Brain 94, 273–288 (1971)PubMedCrossRefGoogle Scholar
  27. Sokoloff, L.: Cerebral circulatory and metabolic changes associated with aging. Res. Publ. Assoc. Nerv. Ment. Dis. 41, 237–254 (1966)Google Scholar
  28. Strandgaard, S., Olesen, J., Skinjøj, E., Lassen, N.A.: Autoregulation of brain circulation in severe arterial hypertension. Br. Med. J. 1, 507–510 (1973)PubMedCrossRefGoogle Scholar
  29. Tomlinson, B.E., Henderson, G.: Some quantitative cerebral findings in normal and demented old people. In: Neurobiology of aging. Terry, R.D., Gershon, S. (eds.), pp. 183–204. New York: Raven Press 1976Google Scholar
  30. Tomlinson, B.E., Blessed, G., Roth, M.: Observations on the brains of demented old people. J. Neurol. Sci. 11, 205–242 (1970)PubMedCrossRefGoogle Scholar
  31. Wang, H.S., Busse, E.W.: Correlates of regional cerebral blood flow in elderly community residents. In: Blood flow and metabolism in the brain. Harper, A.M., Jennett, W.B., Miller, J.D., Rowan, J.O. (eds.), pp. 8.17–8.18. London: Churchill Livingstone 1975Google Scholar
  32. Yamaguchi, F., Meyer, J.S., Sakai, F., Yamamoto, M.: Behavioral activation testing in the dementias. In: Cerebral vascular disease: 9th International Conference Salzburg. Meyer, J.S., Lechner, H., Reivich, M., Ott, E. (eds.). Amsterdam: Excerpta Medica (in press, 1979)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • W. D. Obrist

There are no affiliations available

Personalised recommendations