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Chemistry and Biologic Activity of Peptides Related to Bradykinin

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Bradykinin, Kallidin and Kallikrein

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 25 / 1))

Abstract

The great physiologic importance of the kinin system has prompted much investigation, during the last decade, of the chemistry, pharmacology and physiology of the peptides which constitute and affect this system. Since the earlier tabulation of bradykinin analogs in this work (Schröder, 1970), nearly 150 peptides related in structure to bradykinin have been synthesized and described. These new kinin analogs are tabulated in this chapter and the information gained from the study of these peptides is discussed. The attempts to make good peptide inhibitors of bradykinin will also be discussed.

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  1. J. M. Stewart
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  1. Departments of Pharmacology, and Internal Medicine, The University of Texas, Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX, 75235, USA

    Ervin G. Erdös

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Stewart, J.M. (1979). Chemistry and Biologic Activity of Peptides Related to Bradykinin. In: Erdös, E.G. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, vol 25 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67301-6_5

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