Skip to main content
SpringerLink
Log in

Kallikrein in Exocrine Glands

  • Chapter
Bradykinin, Kallidin and Kallikrein

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 25 / 1))

Abstract

The earliest citations of a hypotensive substance (urohypotensine) resembling kallikrein appeared in the publications of Abelous and Bardier (1908, 1909). Later, similar hypotensive activity was observed by Pribram and Hernheiser (1920) in urine and by Migay and Petroff (1925) in pancreatic juice. About 50 years ago, attempts by Frey and Kraut to locate the source of a hypotensive macromolecule (F-Stoff) which they had characterized in urine (Frey and Kraut, 1928) and in serum (Kraut et al., 1928) led them to the discovery of a similar substance in a pancreatic cyst (Frey et al., 1930). Mammalian pancreas was subsequently found to contain such large amounts of F-Stoff that it was believed to be the site of origin of the hypotensive activity observed by them in urine and blood. This new substance was called “Kreislaufhormon” because of its marked vascular effects. F-Stoff was renamed “kallikrein,” the term being derived from the Greek word Kallikreas meaning pancreas. Later experiments indicated that pancreatic kallikrein was primarily released into the pancreatic juice in a precursor form which was readily activated by duodenal enterokinase (Frey and Werle, 1933; Werle, 1934). This finding spurred Werle and colleagues to search for this enzyme in other glandular tissues. Investigation of salivary tissue resulted in the identification of kallikrein in the submandibular glands of a number of mammals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abelous, J. E, Bardier, E.: Action hypertensive de l’urine humaine normale. C.R. Soc. Biol. (Paris) 64,848–849 (1908)

    Google Scholar 

  • Abelous, J. E, Bardier, E.: Les substances hypotensives de l’urine humaine normale. C.R. Soc. Biol. (Paris) 66, 511–512 (1909)

    CAS  Google Scholar 

  • Adetuyibi, A, Mills, I.H.: Relationship between urinary kallikrein and renal function, hypertension, and excretion of sodium and water in man. Lancet 1972/II,203–207

    Google Scholar 

  • Albano, Janet, Bhoola, K.D, Croker, M, Harvey, R.F, Heap, P.F.: Stimulus-secretion coupling in the pancreas: role of cyclic GMP in modulating enzyme secretion produced by acetylcholine and cholecystokinin-pancreozymin. J. Physiol. (Lond.) 258, 87–88P (1976a)

    Google Scholar 

  • Albano, Janet, Bhoola, K.D, Harvey, R.F.: Cholecystokinin-pancreozymin and acetylcholinemediated increase in enzyme secretion and cyclic GMP levels in the pancreas. In: Stimulussecretion coupling in the gastrointestinal tract. Case, R.M, Goebell, H. (eds.), pp. 227–231. Lancaster: MTP 1975

    Google Scholar 

  • Albano, Janet, Bhoola, K.D, Harvey, R.F.: Intracellular messenger role of cyclic GMP in exocrine pancreas. Nature (Lond.) 262,404–406 (1976b)

    CAS  Google Scholar 

  • Albano, Janet, Bhoola, K.D, Heap, P.F, Lemon, M.J.C.: Stimulus-secretion coupling: Role of cyclic AMP, cyclic GMP, and calcium in mediating enzyme (kallikrein) secretion in the submandibular gland. J. Physiol. (Lond.) 258,631–658 (1976c)

    CAS  Google Scholar 

  • Albano, Janet, Bhoola, K.D, Kingsley, Gabrielle: The control of cyclic GMP by calcium, ionophore A 23187, potassium and acetylcholine in enzyme-secreting pancreatic slices. J. Physiol. (Lond.) 267, 35–36P (1977)

    Google Scholar 

  • Angelleti, R.A, Angeletti, P.U, Calissano, P.: Testosterone induction of estro-proteolytic activity in the mouse submaxillary gland. Biochim. Biophys. Acta 139, 372–381 (1967)

    Google Scholar 

  • Barlow, R. B, Berry, K. J, Glenton, P. A. M, Nikolaou, N. M, Soh, K. S.: A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 °C and in ileum at 29 °C and 37 °C. Br. J. Pharmacol. 58,613–620 (1976)

    PubMed  CAS  Google Scholar 

  • Barton, S, Karpinski, E, Moriwaki, C, Schachter, M.: Sialotonin: Vasopressor substance in saliva and submandibular gland of the cat. J. Physiol. (Lond.) 261, 523–533 (1976)

    CAS  Google Scholar 

  • Barton, S, Saunders, E.J, Schachter, M, Uddin, M.: Autonomic nerve stimulation, kallikrein content and acinar cell granules of the cat’s submandibular gland. J. Physiol. (Lond.) 251, 363–369 (1975)

    CAS  Google Scholar 

  • Beilenson, S, Schachter, M, Smaje, L. H.: Secretion of kallikrein and its role in vasodilatation in the submaxillary gland. J. Physiol. (Lond.) 199,303–317 (1968)

    CAS  Google Scholar 

  • Beraldo, W.T, Siqueira, G, Rodrigues, J. A. A, Machado, C.R.S.: Changes in kallikrein activity of rat submandibular gland during postnatal development. Ad. Exp. Med. Biol. 21, 239–249 (1972)

    CAS  Google Scholar 

  • Bhoola, K.D.: Intracellular distribution of submaxillary kallikrein. J. Physiol. (Lond.) 196, 431–445 (1968)

    CAS  Google Scholar 

  • Bhoola, K.D.: Comparative study of the subcellular distribution of submaxillary kallikrein. Biochem. Pharmacol. 18,1252–1254 (1969)

    PubMed  CAS  Google Scholar 

  • Bhoola, K.D.: Kallikrein granules in the submaxillary gland and pancreas. Adv. Exp. Med. Biol. 8,615–619(1970)

    CAS  Google Scholar 

  • Bhoola, K.D, Cogdell, R.: Electrophoresis of isolated secretory granules from the submaxillary gland. Br. J. Pharmacol. 50,419–423 (1974)

    PubMed  CAS  Google Scholar 

  • Bhoola, K.D, Dorey, Gundula: Isolation of kallikrein-containing granules from the pancreas and submaxillary gland of the cat. J. Physiol. (Lond.) 203, 59–60P (1969)

    Google Scholar 

  • Bhoola, K.D, Dorey, Gundula: Intracellular localization of kallikrein, trypsin, and amylase in dog pancreas. J. Physiol. (Lond.) 214, 553–570 (1971a)

    CAS  Google Scholar 

  • Bhoola, K.D, Dorey, Gundula: Kallikrein, trypsin-like proteases, and amylase in mammalian submaxillary glands. Br. J. Pharmacol. 43,784–793 (1971b)

    CAS  Google Scholar 

  • Bhoola, K.D, Dorey, Gundula, Jones, C.W.: The influence of androgens on enzymes (chymotrypsin and trypsin-like proteases, renin, kallikrein, and amylase) and on cellular structure of the mouse submaxillary gland. J. Physiol. (Lond.) 235, 503–522 (1973)

    CAS  Google Scholar 

  • Bhoola, K.D, Dorey, Gundula, Jones, C.W.: The ontogenic development and action of sex hormones on kallikrein and other proteases in the submaxillary gland. In: Chemistry and biology of the kallikrein-kinin system in health and disease. Pisano, J. J, Austen, K. F. (eds.), pp. 365–373. Fogarty Internat. Center Proc. No. 27. Washington: U.S. Gov. Printing Office 1977

    Google Scholar 

  • Bhoola, K.D, Heap, P.F.: Properties of kallikrein-containing granules isolated from the submaxillary gland of the guinea-pig. J. Physiol. (Lond.) 210,421–432 (1970)

    CAS  Google Scholar 

  • Bhoola, K.D, Lemon, M.J.C.: Studies on the activation of adenylate cyclase from the submaxillary gland and pancreas. J. Physiol. (Lond.) 232, 83–84P (1973)

    Google Scholar 

  • Bhoola, K.D, Lemon, M.J.C.: Studies on enzyme secretion and cyclic AMP in the submaxillary gland and pancreas. J. Physiol. (Lond.) 245,121–122P (1975)

    Google Scholar 

  • Bhoola, K.D, Lemon, M.J.C., Matthews, R.W.: Immunofluorescent localization of kallikrein in guinea-pig submandibular gland. J. Physiol. (Lond.) 272,28–29P (1977)

    Google Scholar 

  • Bhoola, K.D, Matthews, R.W, Roberts, Fiona: Time-course of changes in salivary kallikrein during the menstrual cycle. J. Physiol. (Lond.) 273, 36P (1977)

    CAS  Google Scholar 

  • Bhoola, K.D, McNicol, M.W, Oliver, S, Foran, J.: Changes in salivary enzymes in sarcoidosis. N. Engl. J. Med. 281, 877–879 (1969)

    PubMed  CAS  Google Scholar 

  • Bhoola, K.D, Morley, J, Schachter, M, Smaje, L. H.: Vasodilatation in the submaxillary gland of the cat. J. Physiol. (Lond.) 179,172–184 (1965)

    CAS  Google Scholar 

  • Bhoola, K.D, Ogle, C.W.: Subcellular localisation of kallikrein, amylase, and acetylcholine in the submaxillary gland of the guinea-pig. J. Physiol. (Lond.) 184,663–672 (1966)

    CAS  Google Scholar 

  • Brandtzaeg, P, Gautvik, K.M, Nustad, K, Pierce, J.V.: Rat submandibular gland kallikreins: Purification and cellular localization. Br. J. Pharmacol. 56,155–167 (1976)

    PubMed  CAS  Google Scholar 

  • Bunch, J.L.: On the changes in the volume of the submaxillary gland during activity. J. Physiol. (Lond.) 26,1–29 (1900)

    CAS  Google Scholar 

  • Burnstock, G.B.: Purinergic nerves. Pharmacol. Rev. 24, 509–581 (1972)

    PubMed  CAS  Google Scholar 

  • Caramia, F.: Ultrastructure of mouse submaxillary gland. I. Sexual differences. J. Ultrastruct. Res. 16, 505–523 (1966a)

    CAS  Google Scholar 

  • Caramia, F.: Ultrastructure of mouse submaxillary gland. II. Effect of castration in the male. J. Ultrastruct. Res. 16, 524–536 (1966b)

    CAS  Google Scholar 

  • Carvalho, I.F, Diniz, C.R.: Cellular localization of renin and kininogen. Ciencia Cult (Sao Paulo) 16,263(1964)

    Google Scholar 

  • Chiang, T.S, Erdös, E.G., Miwa, I, Tague, L.L, Coulson, J. J.: Isolation from a salivary gland of granules containing renin and kallikrein. Circulation Res. 23,507–517 (1968)

    PubMed  CAS  Google Scholar 

  • Darke, A. C, Smaje, L. H.: Dependence of functional vasodilation in the cat submaxillary gland upon stimulation frequency. J. Physiol. (Lond.) 226,191–203 (1972)

    CAS  Google Scholar 

  • Dorey, Gundula, Bhoola, K.D.: II. Ultrastructure of duct cell granules in mammalian submaxillary glands. Z. Zellforsch. 126,335–347 (1972)

    PubMed  CAS  Google Scholar 

  • Douglas, W.W.: Stimulus-secretion coupling. The concept and clues from chromaffin and other cells. Br. J. Pharmacol. 34,451–474 (1968)

    PubMed  CAS  Google Scholar 

  • Eichner, H, Eichner, V, Fiedler, F, Hochstrasser, K.: Zum Sekretionsverhalten der BAEEEsterase (Kallikrein) im gesunden menschlichen Parotissekret unter fraktionierter Abnahme bei Ruhe und Reiz. Laryng. Rhinol. 55,239–244 (1976)

    CAS  Google Scholar 

  • Ekfors T.O, Hopsu-Havu, V.K, Malmiharju, T.: Increased vascular permeability caused by the trypsin-like enzymes purified from rat submandibular gland. Acta Physiol. Scand. 75, 157–160(1969)

    PubMed  CAS  Google Scholar 

  • Ekfors, T.O, Malmiharju, T, Hopsu-Havu, V. K.: Isolation of six trypsin-like esteropeptidase from the mouse submandibular gland. Enzymologia 43,151–165 (1972)

    PubMed  CAS  Google Scholar 

  • Ekfors, T.O, Malmiharju, T, Riekkinen, P.J, Hopsu-Havu, V.K.: The depressor activity of trypsin-like enzymes purified from rat submandibular gland. Biochem. Pharmacol. 16, 1634–1639 (1967a)

    CAS  Google Scholar 

  • Ekfors, T.O, Riekkinen, P.J, Malmiharju, T, Hopsu-Havu, V.K.: Four isozymic forms of a peptidase resembling kallikrein purified from the rat submandibular gland. Hoppe Seylers Z. Physiol. Chem. 348,111–118 (1967b)

    CAS  Google Scholar 

  • Emmelin, N, Henriksson, K. G.: Depressor activity of saliva after section of the chorda tympani. Acta Physiol. Scand. 30,75–82 (1953)

    Google Scholar 

  • Erdös, E. G, Tague, L. L, Miwa, I.: Kallikrein in granules of the submaxillary gland. Biochem. Pharmacol. 17,667–674 (1968)

    PubMed  Google Scholar 

  • Feldberg, W, Guimarais, J.A.: Some observations on salivary secretion. J. Physiol. (Lond.) 85, 15–35(1935)

    CAS  Google Scholar 

  • Ferreira, S.H, Smaje, L.H.: Bradykinin and functional vasodilatation in the salivary gland. Br. J. Pharmacol. 58,201–209 (1976)

    PubMed  CAS  Google Scholar 

  • Fiedler, F, Werle, E.: Vorkommen zweier Kallikreinogene im Schweinpankreas und Automation der Kallikrein-und Kallikreinogenbestimmung. Hoppe Seylers Z. Physiol. Chem. 348, 1087–1089 (1967)

    PubMed  CAS  Google Scholar 

  • Forrell, M. M.: Pancreatic kallikrein in physiological and pathological conditions. In: Polypeptides which affect smooth muscles and blood vessels. Schachter, M. (ed.), pp. 247–252. Oxford: Pergamon Press 1960

    Google Scholar 

  • Frey, E. K, Kraut, H.: Ein neues Kreislaufhormon und seine Wirkung. Naunyn Schmiedebergs Arch. Pharmak. 133,1–56 (1928)

    CAS  Google Scholar 

  • Frey, E. K, Kraut, H, Schultz, F.: Über eine neue innersekretorische Funktion des Pankreas. Naunyn Schmiedebergs Arch. Pharmakol. 158,334–347 (1930)

    CAS  Google Scholar 

  • Frey, E.K, Werle, E.: Kallikrein im inneren und aÜber en Pankreassekret. Klin. Wochenschr. 12, 600–601 (1933)

    CAS  Google Scholar 

  • Garrett, J.R.: The innervation of salivary glands. III. The effects of certain experimental procedures on cholinesterase-positive nerves in glands of the cat. J1 R. microsc. Soc. 86, 1–13 (1966a)

    CAS  Google Scholar 

  • Garrett, J.R.: The innervation of salivary glands. IV. The effects of certain experimental procedures on the ultrastructure of nerves in glands of the cat. J1 R. microsc. Soc. 86, 15–31 (1966b)

    CAS  Google Scholar 

  • Garrett, J.R, Kidd, A.: Effects of nerve stimulation and denervation on secretory material in submandibular striated duct cells of cats, and the possible role of these cells in the secretion of salivary kallikrein. Cell. Tissue Res. 161,71–84 (1975)

    PubMed  CAS  Google Scholar 

  • Gautvik, K.: Studies on vasodilator mechanisms in the submandibular salivary gland of cats. Universitetsforlaget 1970

    Google Scholar 

  • Gautvik, K. M, Berg-Oerstadvik, T, Nustad, K.: Role of kallikrein-kinin system in glandular secretion. In: Chemistry and biology of the kallikrein-kinin system in health and disease. Pisano, J.J, Austen, K.F. (eds.), pp. 335–357. Fogarty Internat. Center Proc. No. 27. Washington: U.S. Gov. Printing Office 1977

    Google Scholar 

  • Gautvik, K. M, Kriz, M.: Release of kallikrein from isolated cellular organelles of the rat submandibular salivary gland. Acta Physiol. Scand. 92,95–102 (1974)

    PubMed  CAS  Google Scholar 

  • Gautvik, K.M, Kriz, M, Lund-Larsen, K, Nustad, K.: Control of kallikrein secretion from salivary glands. In: Secretory mechanisms of exocrine glands. Thorn, N.A, Pettersen, O. (eds.), pp. 168–182. Copenhagen: Munksgaard 1974

    Google Scholar 

  • Geipert, F, Erdös, E. G.: Properties of granules that contain kallikrein and renin. Experientia 27, 912–913 (1971)

    PubMed  CAS  Google Scholar 

  • Heidenhain, R.: Über die Wirkung einiger Gifte auf die Nerven der glandula submaxillaris. Pflugers Arch. 5,309–318 (1972)

    Google Scholar 

  • Hickson, J.C.D.: The secretion of pancreatic juice in response to stimulation of the vagus nerves in the pig. J. Physiol. (Lond.) 206,275–297 (1970a)

    CAS  Google Scholar 

  • Hickson, J.C.D.: The secretory and vascular response to nervous and hormonal stimulation in the pancreas of the pig. J. Physiol. (Lond.) 206,299–322 (1970b)

    CAS  Google Scholar 

  • Hilton, S.M.: The physiological role of glandular kallikreins. In: Handbook of experimental pharmacology. Vol. XXV: Bradykinin, kallidin, and kallikrein. Erdös, E.G. (ed.), pp. 389–399 Berlin, Heidelberg, New York: Springer 1970

    Google Scholar 

  • Hilton, S.M, Jones, M.: The role of plasma kinin in functional vasodilatation in the pancreas. J. Physiol. (Lond.) 795, 521–533 (1968)

    Google Scholar 

  • Hilton, S. M, Lewis, G. P.: The cause of the vasodilatation accompanying activity in the submandibular gland. J. Physiol. (Lond.) 128,235–248 (1955)

    CAS  Google Scholar 

  • Hilton, S.M, Lewis, G.P.: The relationship between glandular activity, bradykinin formation and functional vasodilatation in the submandibular gland. J. Physiol. (Lond.) 134, 471–483 (1956)

    CAS  Google Scholar 

  • Hojima, Y, Maranda, B, Moriwaki, C, Schachter, M.: Direct evidence for the location of kallikrein in the striated ducts of the cat’s submandibular gland by the use of specific antibody. J. Physiol. (Lond.) 268,193-801 (1977)

    Google Scholar 

  • Jacobsen, S.: Substrates for plasma kinin-forming enzymes in rat and guinea-pig plasma. Br. J. Pharmacol. 28,64–72 (1966)

    CAS  Google Scholar 

  • Jacoby, F, Leeson, C.R.: The post-natal development of the rat submandibular gland. J. Anat. 93,201–216(1959)

    PubMed  CAS  Google Scholar 

  • Junqueira, L.C, Fajer, A, Rabinovitch, M, Frankenthal, L.: Biochemical and histochemical observations on the sexual dimorphism of mice submaxillary glands. J. Cell. Comp. Physiol. 34,129–135 (1949)

    CAS  Google Scholar 

  • Kraut, H, Frey, E. K, Bauer, E.: Über ein neues Kreislaufhormon. II. Mitteilung. Hoppe Seylers Z. Physiol. Chem. 175,97 (1928)

    CAS  Google Scholar 

  • Kraut, H, Frey, E. K, Werle, E.: Der Nachweis eines Kreislaufhormons in der Pankreasdriise. IV. Mitteilung Über dieses Kreislaufhormon. Hoppe Seylers Z. Physiol. Chem. 189, 97–106 (1930)

    CAS  Google Scholar 

  • Lacassagne, A.: Dimorphisme sexuel de la glande sous-maxillaire chez la souris. C.R. Soc. Biol. (Paris) 133,180–181 (1940)

    CAS  Google Scholar 

  • Lemon, M.J.C, Bhoola, K.D.: Excitation-secretion coupling in exocrine glands: Properties of cyclic AMP phosphodiesterase and adenylate cyclase from the submaxillary gland and pancreas. Biochim. Biophys. Acta 385,101–113 (1975)

    PubMed  CAS  Google Scholar 

  • Marin-Grez, M, Cottone, P, Carretero, O. A.: Evidence for an involvement of kinins in regulation of sodium excretion. Am. J. Physiol. 223,794–796 (1972)

    PubMed  CAS  Google Scholar 

  • Matthews, E. K.: The ionogenic nature of the granule surface. In: Subcellular organisation and function in endocrine tissues. Heller, H, Lederis, K. (eds.), pp. 959–968. Cambridge: University Press 1971

    Google Scholar 

  • Matthews, R.W.: Measurement of protein synthesis in the rat submandibular gland using tritiated tryptophane. Arch. Oral. Biol. 19,985–988 (1974)

    PubMed  CAS  Google Scholar 

  • Matthews, R.W, Beynon, A.D.G, Tonge, C.H.: A preliminary study into the significance of the granular convoluted tubule of the rat submandibular gland. J. Dent. Res. 50, 677 (1971)

    Google Scholar 

  • Matthews, R.W, Bhoola, K.D.: Influence of sympathetic nerve stimulation on the kallikrein content and secretory granules in the guinea-pig submandibular gland. J. Dent. Res. 55, D123 (1976)

    Google Scholar 

  • Matthews, R.W, Bhoola, K.D.: Autonomic control of kallikrein and amylase in guinea-pig submandibular glands. J. Dent. Res. 56, D130 (1977)

    Google Scholar 

  • Migay, T.I, Petroff, J.R.: Untersuchungen über die Wirkung des Pancreassaftes auf den Organismus bei parenteraler Einfuhrung. Z. Gesamte Exp. Med. 36,457 (1923)

    Google Scholar 

  • Mills, I.H, Ward, P. E.: The relationship between kallikrein and water excretion and the conditional relationship between kallikrein and sodium excretion. J. Physiol. (Lond.) 246, 695–707 (1975)

    CAS  Google Scholar 

  • Moriwaki, C, Hojima, Y, Schachter, M.: Purification of kallikrein from cat submaxillary gland. Adv. Exp. Med. Biol. 70,151–156 (1975)

    Google Scholar 

  • Oliver, G, Schafer, E.A.: On the physiological action of extracts of pituitary body and certain other glandular organs. J. Physiol. 18,277 (1895)

    PubMed  CAS  Google Scholar 

  • Oliver, W.J, Gross, F.: Effect of testerone and duct ligation on submaxillary renin-like principle. Am. J. Physiol. 213,341–349 (1967)

    PubMed  CAS  Google Scholar 

  • Orstavik, T. B, Brandtzaeg, P, Nustad, K, Halvorsen, K. M.: Cellular localization of kallikreins in rat submandibular and sublingual salivary glands. Immunofluorescent tracing related to histochemical characteristics. Acta Histochem. (Jena) 54,183–192 (1975)

    CAS  Google Scholar 

  • Palm, S, Schill, W.B, Wallner, O, Prinzen, R, Fritz, H.: Occurrence of components of the kallikrein-kinin system in human genital tract secretions and their possible function in stimulation of sperm motility and migration. Adv. Exp. Med. Biol. 70,271–280 (1975)

    Google Scholar 

  • Pisano, J. J, Geller, R, Margolius, H. S, Keiser, H. S.: Urinary kallikrein in hypertensive rats. Acta Physiol. Lat. Am. 24,73–78 (1974)

    Google Scholar 

  • Poulsen, J. H.: Two phases of chorda-lingual induced vasodilatation in the cat’s submandibular gland during prolonged perfusion with Locke solution. J. Physiol. (Lond.) 253,19–94 (1975)

    Google Scholar 

  • Pribram, H, Hernheiser, G.: Zur Kenntnis der adialysablen Bestandteile des Menschenharnes. Biochem. Z. 111, 30 (1920)

    CAS  Google Scholar 

  • Rawlinson, H.E.: Cytological changes after autonomic and adrenalin stimulation of the cat’s submaxillary gland. Anat. Rec. 57,289–296 (1933)

    Google Scholar 

  • Rawlinson, H. E.: The changes in the cells of the striated ducts of the cat’s submaxillary gland after autonomic stimulation and nerve section. Anat. Rec. 63,295–313 (1935) ai]Schachter, M.: Kallikreins and kinins. Physiol. Rev. 49, 509–547 (1969)

    Google Scholar 

  • Schachter, M.: Vasodilatation in the submaxillary gland of the cat, rabbit, and sheep. In: Handbook of experimental pharmacology. Vol. XXV: Bradykinin, kallidin, and kallikrein. Erdös, E.G. (ed.), pp. 400–408. Berlin, Heidelberg, New York: Springer 1970

    Google Scholar 

  • Schachter, M, Barton, S.: Recent observations on salivary, renal, and coagulating gland kininogenases. In: Chemistry and biology of the kallikrein-kinin system in health and disease. Pisano, J.J, Austen, K.F. (eds.), pp. 359–364. Fogarty Internat. Center Proc. No. 27. Washington: U.S. Gov. Printing Office 1977

    Google Scholar 

  • Schachter, M, Barton, Susanne, Uddin, M, Karpinski, E, Saunders, E.J.: Effect of nerve stimulation, denervation, and duct ligation on kallikrein content and duct cell granules of the cat’s submandibular gland. Experientia (1977)

    Google Scholar 

  • Scott, B. L, Pease, D. C.: Electron microscopy of the salivary and lacrimal glands of the rat. Am. J. Anat. 704,115–140 (1959)

    Google Scholar 

  • Siebert, G, Werle, E, Jung, G, Maier, L.: Intracellular Verteilung von Kallikrein und von Bradykininogen in Schweinepankreas. Biochem. Z. 326,420–423 (1955)

    PubMed  CAS  Google Scholar 

  • Siekevitz, P, Palade, G. E.: A cytochemical study on pancreas of the guinea-pig. I. Isolation and enzymic activities of cell fractions. J. Biophys. Biochem. Cytol. 4,203–217 (1958)

    PubMed  CAS  Google Scholar 

  • Smaje, L. H.: Spontaneous secretion in the rabbit submaxillary gland. In: Secretory mechanism of exocrine glands. Alfred Benzon Symposium VII. Thorn, N.A, Peterson, O.H. (eds.), pp. 608–625. Copenhagen: Munksgaard 1974

    Google Scholar 

  • Sreebny, L.M, Meyer, J.: Hormones, inanition, and salivary glands. In: Salivary glands and their secretions. Sreebny, L.M, Meyer, J. (eds.), pp. 83–102. Oxford: Pergamon Press 1964

    Google Scholar 

  • Thulin, A.: Motor and secretory effects of autonomic nerves and drugs in the rat submandibular gland. Acta Physiol. Scand. 92,217–223 (1974)

    PubMed  CAS  Google Scholar 

  • Trautschold, I, Werle, E, Schmal, A, Hendrikoff, N.G.: Die hormonelle Beeinflussung des Isorenin-Spiegels der Submandibularisdriise der weiBen Maus und zur Lokalisierung des Enzymes in der Druse. Hoppe Seylers Z. Physiol. Chem. 344,232–243 (1966)

    PubMed  CAS  Google Scholar 

  • Ungar, G, Parrot, J. L.: Sur la presence de la callicreine dans la salive, et la possibilite de son intervention dans la transmission chimique de l’influx nerveux. C.R. Soc. Biol. (Paris) 122, 1052–1055(1936)

    CAS  Google Scholar 

  • Vogel, R, Werle, E.: Kallikrein inhibitors. In: Handbook of experimental pharmacology. Vol. XXV: Bradykinin, kallidin, and kallikrein. Erdös, E.G. (ed.), pp. 213–249. Berlin, Heidelberg, New York: Springer 1970

    Google Scholar 

  • Webster, Marion E.: Kallikreins in glandular tissues. In: Handbook of experimental pharmacology. Vol. XXV: Bradykinin, kallidin, and kallikrein. Erdös, E.G. (ed.), pp. 131–155. Berlin, Heidelberg, New York: Springer 1970

    Google Scholar 

  • Werle, E.: Zur Kenntnis des Haushalts des Kallikreins. Biochem. Z. 269,415–434 (1934)

    CAS  Google Scholar 

  • Werle, E.: Über die Wirkung des Kallikreins auf den isolierten Darm und Über eine neue darmkontrahierende Substanz. Biochem. Z. 281,217–233 (1937)

    Google Scholar 

  • Werle, E.: Kallikrein, kallidin, and related substances. In: Polypeptides which affect smooth muscles and blood vessels. Schachter, M. (ed.), pp. 199–209. Oxford: Pergamon Press 1960

    Google Scholar 

  • Werle, E, Berek, U.: Zur Kenntnis des Kallikreins. Z. Angew. Chem. 60A, 53 (1948)

    Google Scholar 

  • Werle, E, Eckey, P.: Vergleichende Untersuchung über Kallikrein und Trypsinkonzentration im menschlichen Duodenalsaft. Biochem. Z. 269,435–440 (1934)

    CAS  Google Scholar 

  • Werle, E, Forell, M. M, Maier, L.: Zur Kenntnis der blutdrucksenkenden Wirkung des Trypsins. Naunyn Schmiedebergs Arch. Pharmakol. 225, 369 (1955)

    CAS  Google Scholar 

  • Werle, E, Gotze, W, Keppler, A.: Über die Wirkung des Kallikreins auf den isolierten Darm und über eine neue darmkontrahierende Substanz. Biochem. Z. 289,217–233 (1937)

    CAS  Google Scholar 

  • Werle, E, Grunz, M.: Zur Kenntnis der darmkontrahierenden uteruserregenden und blutdrucksenkenden Substanz DK. Biochem. Z. 301,429–436 (1939)

    CAS  Google Scholar 

  • Werle, E, Korsten, H.: Das Kallikreingehalt des Harns, des Speichels und des Blutes bei Gesunden und Kranken. Z. Gesamte Exp. Med. 10103,153 (1938)

    Google Scholar 

  • Werle, E, Rosen, P.: Über das Vorkommen von Kallikrein in den Speicheldriisen und im Mundspeichel. Biochem. Z. 286,213–219 (1936)

    CAS  Google Scholar 

  • Werle, E, Roden, P.: Über das Vorkommen von Kallikrein in den Speicheldriisen und im Mundspeichel und über eine blutdrucksteigernde Substanz in der Submaxillarisdruse des Hundes. Biochem. Z.,301,328–337 (1939)

    CAS  Google Scholar 

  • Werle, E, Urhahn, K.: Über den Aktivitatszustand des Kallikreins in der Bauchspeicheldruse. Biochem. Z. 304,387–396 (1940)

    CAS  Google Scholar 

  • Werle, E, Vogel, R, Goldel, L. F.: Über ein blutdrucksteigerndes Prinzip in Extrakten aus der Glandula submaxillaris der weißen Maus. Naunyn Schmiedebergs Arch. Exp. Path. Pharmakol. 230,236 (1957)

    CAS  Google Scholar 

  • Wotman, S, Greenbaum, L, Mandel, I.: Studies on human salivary kallikrein. Biochem. Pharmacol. 18,1261–1264(1969)

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. K. Bhoola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Lemon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Matthews
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Pharmacology, and Internal Medicine, The University of Texas, Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX, 75235, USA

    Ervin G. Erdös

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bhoola, K., Lemon, M., Matthews, R. (1979). Kallikrein in Exocrine Glands. In: Erdös, E.G. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, vol 25 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67301-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67301-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67303-0

  • Online ISBN: 978-3-642-67301-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation