Pathogenesis of Block of Rapid Orthograde Axonal Transport by Elevated Intraocular Pressure
Although axoplasmic flow blockage (AFB) with raised intraocular pressure (IOP) is well-established (1–11), its pathogenesis remains an enigma. AFB may be due to ischemia of the optic nerve fibers (6) or mechanical axonal compression (8). The present study was designed to determine whether the AFB is due to ischemia or mechanical compression of the optic nerve fibers in the optic nerve head.
KeywordsIschemia Heparin Serotonin Angiotensin Leucine
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