Pathogenesis of Block of Rapid Orthograde Axonal Transport by Elevated Intraocular Pressure

  • Sohan Singh Hayreh
  • Wayne March
  • Douglas R. Anderson
Conference paper


Although axoplasmic flow blockage (AFB) with raised intraocular pressure (IOP) is well-established (1–11), its pathogenesis remains an enigma. AFB may be due to ischemia of the optic nerve fibers (6) or mechanical axonal compression (8). The present study was designed to determine whether the AFB is due to ischemia or mechanical compression of the optic nerve fibers in the optic nerve head.


Common Carotid Artery Optic Nerve Head Carotid Artery Disease Optic Nerve Fiber Perfusion Pump 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • Sohan Singh Hayreh
    • 1
  • Wayne March
    • 1
  • Douglas R. Anderson
    • 1
  1. 1.Department of OphthalmologyUniversity of IowaIowa CityUSA

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