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Some Current Problems and New Dimensions of Polymeric Biomaterials for Blood Contacting Applications

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Assisted Circulation

Abstract

Biomaterials properly include materials both of synthetic and natural origins which are in contact with living tissue, blood, and other biologic fluids and are used for prosthetic, diagnostic, therapeutic, and storage applications without adversely affecting the biologic components and the living organism [5, 6, 8–10]. “Anti-thrombogenic” behavior and lack of acute toxicologic response are not necessarily indicative of blood compatibility or long-term tolerability in the physiologic environment [11, 13]. Nevertheless, toxicologic screening of candidate biomaterials is absolutely required in conjunction with other biologic test procedures, including determinations of immunologic response and elimination of possible cause of carcinoma. The latter is especially important in the case of long-term implants. “Thromboresistance” is frequently but erroneously equated with “blood compatibility” merely on the basis that no visible clots are present on the test specimens. However, in many cases clots may either appear in various organs as the result of contact between blood and the foreign materials or cause detrimental biochemical and physiologic manifestations when devices are in prolonged use.

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Authors
  1. S. D. Bruck
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Editors and Affiliations

  1. Surgical Clinic, University of Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria

    Felix Unger M.D. (Ass. Prof. of Surgery) (Ass. Prof. of Surgery)

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© 1979 Springer-Verlag Berlin Heidelberg

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Bruck, S.D. (1979). Some Current Problems and New Dimensions of Polymeric Biomaterials for Blood Contacting Applications. In: Unger, F. (eds) Assisted Circulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67268-2_48

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  • DOI: https://doi.org/10.1007/978-3-642-67268-2_48

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67270-5

  • Online ISBN: 978-3-642-67268-2

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