Skip to main content
SpringerLink
Log in

Material Aspects of Cardiac Assist Devices: the Case History of Avcothane 51 Elastomer

  • Chapter
Assisted Circulation

  • 115 Accesses

Abstract

Initiated perhaps by Virchow’s famous triad [25], several schools of thought have evolved advocating the relative or absolute significance of different factors known to affect blood/foreign surface interactions. These phenomena determine the in vivo performance of cardiac assist devices as well in terms of the incidence or absence of intolerable hematologic/physiologic effects. This paper attempts to present a realistic assessment of the significance of material factors, since these influence the in vivo performance of devices both in their developmental phase and at the production level following the achievement of routine clinical application.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Akutsu, T., Kolff, W. J.: Experiments of the total heart substitute in a living dog. Trans. Am. Soc. Artif. Intern. Organs 4, 230 (1958)

    Google Scholar 

  2. Andrade, J. D., Iwamoto, G. K., McNeill, B.: XPS studies of polymer surfaces for biomedical applications. In: Characterization of Metal and Polymer Surfaces, Vol.2. Lee, L.-H. (ed.), pp. 133–141. New York: Academic Press 1977

    Google Scholar 

  3. Brash, J. L., Samak, Q. M.: Dynamics of interactions between human albumin and polyethylene surface. J. Colloid Interface Sci. 65, 495 (1978)

    Article  CAS  Google Scholar 

  4. Clark, D. T., Dilks, A.: Plasma modification of polymers studied by means of ESCA. In: Characterization of Metal and Polymer Surfaces, Vol. 2. Lee, L.-H. (ed.), pp. 101–132. New York: Academic Press 1977

    Google Scholar 

  5. Dunkel, W., Weisshaar, D.: About the stability of polyurethane elastomers in blood; paper presented at the 4th Ann. Mtg., European Society for Artificial Organs; London, England, 1977; abstract in Artif. Organs 1, 121 (1977)

    Google Scholar 

  6. Ghista, D. N., Reul, H.: Optimal prosthetic aortic leaflet valves: design parametric and longevity analyses: development of the avcothane 51 leaflet valve based on the optimum design analysis. J. Biomech. 10, 313 (1977)

    Article  PubMed  CAS  Google Scholar 

  7. Jarvik, R. K., Lawson, J. H., Olsen, D. B., Fukumasu, H., Kolff, W. J.: The beat goes on: status of the artificial heart, 1977. Int. J. Artif. Organs 1, 21 (1978)

    PubMed  CAS  Google Scholar 

  8. Kellner, R., Unger, F.: IR-spectrometric characterization of the blood compatibility of poly-urethane-silicone compolymers. Z. Anal. Chem. 283, 349 (1977)

    Article  CAS  Google Scholar 

  9. Kolff, W. J.: In: Discussion of Manuscript No. 61. Trans. Am. Soc. Artif. Intern. Organs 22, 459 (1976)

    Google Scholar 

  10. Kolff, W. J., Stellwag, F.: Blood at artificial organ surfaces: progress to data as stepping-stones for the future. Ann. N.Y. Acad. Sci. 283, 443 (1977)

    Article  CAS  Google Scholar 

  11. Kolobow, T., Stool, E. V., Weathersby, P. K., Pierce, J., Hayans, F., Suaudeau, J.: Superior blood compatibility of silicone rubber free of silica filler in the membrane lung. Trans. Am. Soc. Artif. Intern. Organs 20A, 269 (1974)

    PubMed  CAS  Google Scholar 

  12. Leinbach, R. C., Nyilas, E., Caulfield, J. B., Buckley, M. J., Austen, W. G.: Evaluation of hematologic effects of intra-aortic balloon assistance in man. Trans. Am. Soc. Artif. Intern. Organs 18, 493 (1972)

    PubMed  CAS  Google Scholar 

  13. Lyman, D. J., Knutson, K., McNeill, B., Shibatani, K.: The effects of chemical structure and surface properties of synthetic polymers on the coagulation of blood. IV. The relation between polymer morphology and protein adsorption. Trans. Am. Soc. Artif. Intern. Organs 21, 49 (1975)

    PubMed  CAS  Google Scholar 

  14. Nyilas, E.: Development of blood-compatible elastomers. I. Theory, practice and in vivo performance. Proc. 23rd Ann. Conf. Eng. Med. Biol. 12, 147 (1970)

    Google Scholar 

  15. Nyilas, E.: Development of blood-compatible elastomers. II. Performance of avcothane blood contact surfaces in experimental animal implantations. J. Biomed. Mater. Res. Symposium 3, 97 (1972)

    Article  CAS  Google Scholar 

  16. Nyilas, E.: Polysiloxane-polyurethane block copolymers; U.S. Patent 3562352 (1971); Italian Patent 882822 (1970); Swiss Patent 505171 (1971); West German Patent 1944969 (1971); French Patent 6930339 (1971); Canadian Patent 878014 (1971); British Patent 1253760 (1972); Japanese Patent 722243 (1974); and Swedish Patent 361051 (1974)

    Google Scholar 

  17. Nyilas, E.: Development of antithrombogenic artificial materials: theory and practice. In: Blood vessels; problems arising at the border of natural and artificial blood vessels. Effert, S., Meyer-Erkelenz, J. D. (eds.), pp. 165–172. Berlin, Heidelberg, New York: Springer 1976

    Google Scholar 

  18. Nyilas, E., Ward, R. S., Jr.: Development of blood-compatible elastomers. V. Surface structure and blood compatibility of avcothane elastomers. J. Biomed. Mater. Res. Symposium 8, 69 (1977)

    Article  Google Scholar 

  19. Nyilas, E., Ward, R. S., Jr.: Production of biomedical polymers. II. Processing technology/product property correlations of hemocompatible avcothane elastomers. In: Proceedings of the International Symposium on Polymer Processing (Massachusetts Institute of Technology, Cambridge, MA, August 1977). Cambridge: MIT Press 1979 (in press)

    Google Scholar 

  20. Nyilas, E., Kupski, E. L., Burnett, P., Haag, R. M.: Surface microstructural factors and the blood compatibility of a silicone rubber. J. Biomed. Mater. Res. 4, 369 (1970)

    Article  PubMed  CAS  Google Scholar 

  21. Nyilas, E., Leinbach, R. C., Caulfield, J. B., Buckley, M. J., Austen, W. G.: Development of blood-compatible elastomers. III. Hematologic effects of avcothane intra-aortic balloon pumps in cardiac patients. J. Biomed. Mater. Res. Symposium 3, 129 (1972)

    Article  Google Scholar 

  22. Nyilas, E., Morton, W. A., Lederman, D. M., Chiu, T.-H., Cumming, R. D.: Interdependence of hemodynamic and surface parameters in thrombosis. Trans. Am. Soc. Artif. Intern. Organs 21, 55 (1975)

    PubMed  CAS  Google Scholar 

  23. Szycher, M., Poirier, V., Keiser, J.: Selection of materials for ventricular assist pump development and fabrication. Trans. Soc. Artif. Intern. Organs 23, 116 (1977)

    CAS  Google Scholar 

  24. Unger, F.: Design and hemodynamic evaluation of the ellipsoid heart for total heart replacement. Wien. Klin. Wochenschr. 89 (65), 3 (1977)

    Google Scholar 

  25. Virchow, R.: In: Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt: Meidinger Verlag 1856

    Google Scholar 

  26. Ward, R. S., Jr., Nyilas, E.: Production of biomedical polymers. I. Silicone/urethane synergy in avcothane elastomers. Coatings and plastics preprints 37(1), 291 (1977)

    Google Scholar 

  27. Waschmann, M.: A new technique for manufacturing integrated leaflet valves for artificial blood pumps. Biomed. Tech. 23, 173 (1978)

    Article  CAS  Google Scholar 

  28. Williams, M. C., Mel, H. C.: The influence of biomaterials and blood chemistry on shear-induced hemolysis. In: Devices and technology branch contractors. Conference Proceedings, 1977. Gerber, K. (ed.), pp. 91–97. DHEW Publication No. (NIH) 78–1601 (1978)

    Google Scholar 

  29. Wilner, G. D., Casarella, W. J., Baier, R., Fenoglis, C. M.: Thrombogenicity of angiographic catheters. Circ. Res. 43, 424 (1978)

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. E. Nyilas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Surgical Clinic, University of Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria

    Felix Unger M.D. (Ass. Prof. of Surgery) (Ass. Prof. of Surgery)

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Nyilas, E. (1979). Material Aspects of Cardiac Assist Devices: the Case History of Avcothane 51 Elastomer. In: Unger, F. (eds) Assisted Circulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67268-2_47

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67268-2_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67270-5

  • Online ISBN: 978-3-642-67268-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation