Abstract
In order to investigate the relationship between mutation and carcinogenesis in vivo, a method has been developed in which somatic mutation can be studied in specific organs of Chinese hamsters after acute dosing with chemical carcinogens.
In preliminary experiments an increase in mutation was detected in cultures derived from lung tissue of hamsters after intraperitoneal dosing with the direct-acting mutagen and weak carcinogen, ethyl methanesulphonate, or with diethyl-nitrosamine, a carcinogen which requires metabolic activation before mutagenic activity can be demonstrated in vitro.
Subsequent experiments have shown the induction of mutation in cells derived from the bladder of animals dosed with diethylnitrosamine or methyl nitrosourea and in a variety of tissues from animals dosed with methane-sulphonates, 2-acetylaminofluorene and 3-methylcholanthrene.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cox, A. J., Jr., Wilson, R. H., De Eds, F.: The carcinogenic activity of 2-acetylaminofluorene: Characteristics of the lesions in albino rats. Cancer Res. 7, 647–657 (1947)
Dean, B. J., Senner, K. R.: Detection of chemically induced somatic mutation in Chinese hamsters. Mutat. Res. 46, 403–407 (1977a)
Dean, B. J., Senner, K. R.: Detection of chemically-induced mutations in tissues of Chinese hamsters. In: Progress in Genetic Toxicology. D. Scott, B. A. Bridges, F. H. Sobels (Eds.), p. 201–206. Amsterdam, New York, Oxford: Elsevier/North Holland Biomedical Press 1977b
Dipple, A.: Polynuclear aromatic carcinogens. In: Chemical Carcinogens. C. E. Searle (Ed.), p. 245–314. Washington, D. C.: Americal Chemical Society 1976
Lawley, P. D.: Carcinogenesis by alkylating agents. In: Chemical Carcinogens. C. E. Searle (Ed.), p. 83–244. Washington, D. C.: American Chemical Society 1976
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag
About this paper
Cite this paper
Dean, B.J., Hodson-Walker, G., Senner, K.R. (1979). Organotropic Mutagenesis in Tissues of Chinese Hamsters Induced by Chemical Carcinogens. In: Chambers, P.L., Günzel, P. (eds) Mechanism of Toxic Action on Some Target Organs. Archives of Toxicology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67265-1_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-67265-1_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09305-3
Online ISBN: 978-3-642-67265-1
eBook Packages: Springer Book Archive