Anitis — Cryptitis — Papillitis
Inflammatory processes within this transitional zone cannot be separated from one another and often occur together. The source of the infection will usually be found in the crypts of Morgagni, originating in the dorsal crypts and spreading to the adjacent papillae. The area of involvement appears erythematous and edematous, and pus occasionally exudes from the crypts. An association exists between cryptitis and the development of anal fissures, and between anal fissures and hemorrhoidal diseases. The anal canal is for the most part also involved in the inflammatory process. One encounters an anitis, which because of an increased secretion produces a perianitis and perpetuates a perianal eczema (Plate VII/1 and 2). Hypertrophy of the papillae then develops (Plate VII/3–6). These changes have also been described with gonorrhea and lues, which can be diagnosed microscopically using a smear or darkfield examination.