Some Aspects of Bacterial Mutagenicity Testing

  • J. Ellenberger
  • G. R. Mohn
Conference paper


In routine mutagenicity testing of environmental chemicals, bacterial systems occupy an important place in test strategies such as those developed by Flamm (1), by Bridges (2), by Bora (3), and by others, and which are in current use in several institutions. The common phases of these tier systems for mutagenicity have been recognized and described by Sobels (4) as (i) primary detection of mutagenic effects in short-term assays, (ii) verification in tests using eukaryotic indicators, (iii) quantification of the effects in animals (in comparison to known mutagens), and (iv) extrapolation to man. Bacterial indicators can and have been used to quantify genetic effects in mammals, for example in the body-fluid test (5) and in host-mediated assays (6–8), but their main role lies in the primary detection of environmental chemicals to be further evaluated for mutagenic and carcinogenic hazards, and several systems in bacteria such as Escherichia coli and Salmonella typhimurium have been described (see 9 and 10).


Mutagenic Activity Chemical Mutagen Carcinogenic Potency Hydrazine Sulfate Prophage Induction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • J. Ellenberger
    • 1
  • G. R. Mohn
    • 2
  1. 1.Zentrallaboratorium für Mutagenitätsprüfung der Deutschen ForschungsgemeinschaftFreiburg i.Br.Germany
  2. 2.Department of Radiation Genetics and Chemical MutagenesisUniversity of LeidenLeidenThe Netherlands

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