Pharmacokinetics of Gastrointestinal Absorption

  • E. Gladtke
  • H. M. von Hattingberg


Some new factors have to be taken into account when considering the pharmacokinetics of blood concentration-time curves of substances absorbed through the gastrointestinal tract. These are: 1) the amount of substance which can be absorbed varies with gastrointestinal filling and emptying; 2) invasion into the circulation often does not obey the laws of simple concentration gradients; 3) the interposition of organs of active metabolism such as the liver or intestinal mucosa can lead to a partial or complete change in the substance absorbed; 4) counter-regulatory in­fluences may affect substances absorbed in the gastrointestinal tract, particularly foodstuffs.


Ascorbic Acid Absorptive Capacity Intestinal Segment Gastrointestinal Absorption Lymphatic Transport 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • E. Gladtke
    • 1
  • H. M. von Hattingberg
    • 2
  1. 1.Universitäts-KinderklinikKöln 41Germany
  2. 2.KinderklinikJustus-Liebig-UniversitätGießenGermany

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