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Pharmacokinetics of Gastrointestinal Absorption

  • E. Gladtke
  • H. M. von Hattingberg

Abstract

Some new factors have to be taken into account when considering the pharmacokinetics of blood concentration-time curves of substances absorbed through the gastrointestinal tract. These are: 1) the amount of substance which can be absorbed varies with gastrointestinal filling and emptying; 2) invasion into the circulation often does not obey the laws of simple concentration gradients; 3) the interposition of organs of active metabolism such as the liver or intestinal mucosa can lead to a partial or complete change in the substance absorbed; 4) counter-regulatory in­fluences may affect substances absorbed in the gastrointestinal tract, particularly foodstuffs.

Keywords

Ascorbic Acid Absorptive Capacity Intestinal Segment Gastrointestinal Absorption Lymphatic Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • E. Gladtke
    • 1
  • H. M. von Hattingberg
    • 2
  1. 1.Universitäts-KinderklinikKöln 41Germany
  2. 2.KinderklinikJustus-Liebig-UniversitätGießenGermany

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