Abstract
KUSCHE and STAHLKNECHT eloborated on the relation between neoplastic growth and polyamine metabolism. Diamine oxydase deaminates putrescine and thereby influences the concentrations of the polyamines putrescine, spermidine, and spermine. The excretion of polyamines in the urine has been found to be increased in cancer patients (1, 2). Diamine oxydase can be detected in the serum of cancer patients and of pregnant women, but not in normal subjects. The authors found increased concentrations of diamine oxydase in tumor tissue compared to normal mucosa (Table 1). Diamine oxydase, Regan isoenzyme, and possibly polyamines may be regarded as tumor-associated antigens or markers of neoplastic growth.
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Neish, W.J.P., Key, L.: Int. J. Cancer 2, 69 (1967)
Neish, W.J.P., Key, L.: Comp. Biochem. Physiol. 27, 709 (1968)
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© 1979 Springer-Verlag Berlin Heidelberg
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Kusche, J., Stahlknecht, C.D. (1979). Discussion. In: Flad, HD., Herfarth, C., Betzler, M. (eds) Immunodiagnosis and Immunotherapy of Malignant Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67166-1_4
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DOI: https://doi.org/10.1007/978-3-642-67166-1_4
Publisher Name: Springer, Berlin, Heidelberg
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