The Role of Glutathione in Transport Activity in Kidney

  • F. H. Leibach
  • D. J. Pillion
  • J. Mendicino
  • D. Pashley
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Diamide oxidizes renal cortical GSH and causes inhibition of amino acid and sugar uptake and gluconeogenesis in the renal cortical slice. However, it does not inhibit the uptake of p-aminohippurate. The effects of diamide can be reversed by the addition of exogenous GSH, while other thiols are less effective. Diamide does not affect renal γ-Glutamyl transpeptidase, alkaline phosphatase, or Mg2+-ATPase, but does inhibit protein kinase activity, both soluble and particulate, microsomal Na+-K+-dependent ATPase and glucose-6-phosphatase. The inhibition of these enzymes is partially reversible upon addition of exogenous thiols. The results suggest that GSH is intimately associated with transport processes in kidney.


Kidney Cortex GSSG Level Dependent ATPase Kidney Slice Renal Cortical Slice 
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© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • F. H. Leibach
  • D. J. Pillion
  • J. Mendicino
  • D. Pashley

There are no affiliations available

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