Since the first isolation and characterization of a DNA-dependent DNA polymerase in 1958 (LEHMAN et al.) a huge body of information has been gathered on the mechanisms and the proteins involved in DNA replication. At present extensive research efforts are still being made to clarify the various aspects of replication in viral and bacterial systems, aswell as in eukaryotic plant and animal cells. The success of research during the past years in the field of replication, with particular emphasis on molecular and biochemical events, is reflected in a series of review articles and monographs which may provide the reader with information on specific aspects of replication or the respective experimental system.
KeywordsReplication Fork Incompatibility Factor Superhelical Turn Negative Control Element Fork Migration
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