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Critical Intracranial Effects of Osmotherapy

  • Conference paper
Treatment of Hydrocephalus Computer Tomography

Part of the book series: Advances in Neurosurgery ((NEURO,volume 6))

Abstract

Shortly following the discovery, by WEED and McKIBBEN in 1919 (27), that intracranial pressure was reduced by intravenous hyperosmolar infusions, this treatment gained clinical, application. BURGER (5) termed this procedure “osmotherapy.” Nowadays mannitol and sorbitol, introduced by WISE and CHATER in 1961 (28), are regarded as being the most effective conservative measure for reducing intracranial pressure (ICP) (2, 12, 25). Even in the absence of a verified ICP elevation, treatment with regular doses of 1 to 2 g/kg body weight is part of the basic therapy of acute intracranial disorders with edema or ischemia in many hospitals (19). At the last intensive care meeting of German neurosurgeons (in Giessen, 1977), more than half of the clinics present reported its regular use in severe head injuries.

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Authors
  1. M. Gaab
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  2. K. W. Pflughaupt
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  3. M. Ratzka
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  4. R. Wodarz
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  5. P. Gruss
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Editors and Affiliations

  1. Neurochirurgische Klinik, Klinikum Westend, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Rolf Wüllenweber

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© 1978 Springer-Verlag Berlin Heidelberg

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Gaab, M., Pflughaupt, K.W., Ratzka, M., Wodarz, R., Gruss, P. (1978). Critical Intracranial Effects of Osmotherapy. In: Wüllenweber, R., Wenker, H., Brock, M., Klinger, M. (eds) Treatment of Hydrocephalus Computer Tomography. Advances in Neurosurgery, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67082-4_34

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  • DOI: https://doi.org/10.1007/978-3-642-67082-4_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67084-8

  • Online ISBN: 978-3-642-67082-4

  • eBook Packages: Springer Book Archive

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