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Leukemic Cell Phenotypes in Man: Relationship to ‘Target’ Cells for Leukemogenesis and Differentiation Linked Gene Expression

  • M. F. Greaves
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 23)

Abstract

Established cell lines derived from malignant cells are proving to be of considerable value in the investigation of differentiation and controls of gene expression. This is especially evident in the leukemias; the Friend virus-induced erythroleukemia (Harrison, 1977), avian erythroleukemia (see Graf, this book) and myeloid leukemias in rats (Lotem and Sachs, 1974) and a recently described human myeloid line (Collins et al., 1978), all having a maturation arrest which can be reversed by various agents and to some extent controlled by viruses (see papers by Gallo, Ruscetti and Graf in this book).

Keywords

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Myeloid Leukemia Acute Lymphoblastic Leukaemia Terminal Deoxynucleotidyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • M. F. Greaves
    • 1
  1. 1.Membrane Immunology LaboratoryImperial Cancer Research FundLincoln’s Inn Fields, LondonGreat Britain

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