Treatment of Childhood Acute Lymphocytic Leukemia

  • D. Pinkel
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 23)

Abstract

Thank you for the honor of sharing in this memorial to Frederick Stohlman. The work I will report today represents the efforts of many physicians and scientists who have tried to understand and control childhood leukemia.

Keywords

Fatigue Lymphoma Leukemia Methotrexate Folic Acid 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arlin, A. A., et al.: Therapeutic role of cell kinetics in acute leukaemia. Clin. Haematol. 7, 339–362 (1978)PubMedGoogle Scholar
  2. 2.
    Aur, R.J.A., et al.: Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood 37, 272–281 (1971)PubMedGoogle Scholar
  3. 3.
    Aur, R.J. A., et al.: A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia. Cancer 29, 381–391 (1972)PubMedCrossRefGoogle Scholar
  4. 4.
    Aur, R.J. A., et al.: Childhood acute lymphocytic leukemia — Study VIII. Cancer 42, 2123–2134 (1978)PubMedCrossRefGoogle Scholar
  5. 5.
    Belpomme, D., et al.: Immunological diagnosis of leukaemia and lymphoma: A World Health Organization/International Union of Immunological Societies technical report. Br. J. Haematol. 38, 85–98 (1978)CrossRefGoogle Scholar
  6. 6.
    Borella, L., et al.: Immunologic rebound after cessation of long-term chemotherapy in acute leukemia. Blood 40, 42–51 (1972)PubMedGoogle Scholar
  7. 7.
    Chessells, J.M., et al.: Acute lymphoblastic leukaemia in children: Classification and prognosis. Lancet 1977 II, 1307–1309Google Scholar
  8. 8.
    Dritschilo, A., et al.: The role of irradiation in central nervous system treatment and prophylaxis for acute lymphoblastic leukemia. Cancer 37, 2729–2735 (1976)PubMedCrossRefGoogle Scholar
  9. 9.
    Riser, C.: Intellectual abilities among survivors of childhood leukaemia as a function of CNS irradiation. Arch. Dis. Child. 53, 391–395 (1978)CrossRefGoogle Scholar
  10. 10.
    Farber, S., et al.: Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopterovlglutamie acid (aminopterin). N. Engl. J. Med. 238, 787–793 (1948)PubMedCrossRefGoogle Scholar
  11. 11.
    Farber, S., et al.: Advances in chemotherapy of cancer in man. Adv. Cancer Res. 4, 1–71 (1956)PubMedCrossRefGoogle Scholar
  12. 12.
    Hughes, W.T., et al.: Successful ehemoprophvlaxis for Pneumocystis carinii pneumonitis. N. Engl. J. Med. 297, 1419–1426 (1977)PubMedCrossRefGoogle Scholar
  13. 13.
    Mcintosh, S., et al.: Intracranial calcifications in childhood leukemia. J. Pediatr. 91, 909–913 (1977)PubMedCrossRefGoogle Scholar
  14. 14.
    Medical Research Council: Treatment of acute lymphoblastic leukaemia: Effect of “prophylactic” therapy against central nervous system leukaemia. Br. Med. J. 2, 381–384 (1973)Google Scholar
  15. 15.
    Pinkel, D.: Treatment of acute lymphocytic leukemia, pp. 151. London: Leukaemia Research Fund Publication 1973Google Scholar
  16. 16.
    Pinkel, D., et al.: Drug dosage and remission duration in childhood lymphocytic leukemia. Cancer 27, 247–256 (1971)PubMedCrossRefGoogle Scholar
  17. 17.
    Price, R. A., Jamieson, P. A.: The central nervous system in childhood leukemia. II. Subacute leukoeneephalopathy. Cancer 35, 306–318 (1975)PubMedCrossRefGoogle Scholar
  18. 18.
    Price, R.A., Johnson, W.W.: The central nervous system in childhood leukemia: I. The arachnoid. Cancer 31, 520–533 (1973)PubMedCrossRefGoogle Scholar
  19. 19.
    Simone, J.: Acute lymphocytic leukemia in childhood. Semin. in Hematol. 11, 25–39 (1974)Google Scholar
  20. 20.
    Tattersall, M.H.N., Tobias, J.S.: Are dose-response relationships relevant in clinical cancer chemotherapy? Recent advances in Cancer treatment. H.J. Tagnon and M.J. Staquet (eds.). pp. 227–233. New York: Raven Press 1977Google Scholar
  21. 21.
    Verzosa, M.S., et al.: Five years after central nervous system irradiation of children with leukemia. Int. J. Radiat. Oncol. Biol. Phys. 1, 209–215 (1976)PubMedCrossRefGoogle Scholar
  22. 22.
    Yarbro, G.S. K., et al.: Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia. Cancer Res. 37, 2688–2695 (1977)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • D. Pinkel
    • 1
  1. 1.Midwest Children’s Cancer CenterMilwaukee Children’s HospitalMilwaukeeUSA

Personalised recommendations