Clonal Diseases of the Myeloid Stem Cell Systems

  • D. R. Boggs
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 23)


The structure and kinetics of the hematopoietic stem cell compartment have long been the subject of considerable speculation. Based on morphologic observations of normal and abnormal human marrow and of a perturbed system in experimental animals, primarily the rabbit, in 1938, Downey [1] concluded there was a stem cell capable of giving rise to all hematopoietic tissue. He believed this cell in turn gave rise to a lymphoid stem cell and to a myeloid stem cell. The myeloid stem cell could give rise directly to erythroid, megakaryocytic and monocytic cell lines and in turn produced a tertiary stem cell which could generate neutrophils, eosinophils and basophils. With the development of functional assays for clonal cell growth in vivo and in vitro and through the use of chromosome marked clones this suggested structure has proved to be correct in substance although certain minor variations are indicated. Most definitive studies of the structure of the stem cell compartment are in mice [2] but, in general, the data generated in human diseases suggest that the human stem cell structure is the same as that of the mouse. In Fig. 1, one current “best guess” is shown. There seems little doubt that at least 3 concatenated precursor compartments exist for all myeloid cells. Whether there are still more intermediate stages and whether or not most cells forming colonies in vitro are stem cells (i.e. capable of self-replication) remain open question.


Stem Cell Chronic Myeloid Leukemia Polycythemia Vera Blastic Crisis Versus Versus Versus Versus Versus 
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  1. 1.
    Downey, H. (ed.): Handbook of Hematology. Vol. 3. p. 2025. New York: Hafner Publishing 1938Google Scholar
  2. 2.
    Abramson, S., Miller, R.G., Phillips, R. A.: The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J. Exp. Med. 145, 1567 (1977)PubMedCrossRefGoogle Scholar
  3. 3.
    Millard, R. E., Okell, S. F.: The effects of cystosine arabinoside in vitro on agar colony forming cells and spleen colony forming cells of C-57BL mouse bone marrow. Cell Tissue Kinet. 8, 33 (1975)PubMedGoogle Scholar
  4. 4.
    Bennet, M., Cudkowicz, G., Foster, R. S. Jr., Metcalf, D.: Hemopoietic Progenitor cells of W anemic mice studied in vivo and in vitro. J. Cell Physiol. 71, 211–226 (1968)CrossRefGoogle Scholar
  5. 5.
    Gregory, C.J., Eaves, A.C.: Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties. Blood 51, 527 (1978)PubMedGoogle Scholar
  6. 6.
    Williams, N., Jackson, H., Sheridan, A.P.C. Murphy, M.J. Jr., Moore, M.A.S.: Regulation of megakaryopoiesis in long-term murine bone marrow cultures. Blood 51, 245 (1978)PubMedGoogle Scholar
  7. 7.
    Chervenick, P. A., Boggs, D. R.: In vitro growth of granulocytic and mononuclear cell colonies from blood of normal individuals. Blood 37, 131 (1971)PubMedGoogle Scholar
  8. 8.
    Whang-Peng, J.: Cytogenetic studies on acute myelocytic leukemia. Blood 34,448 (1970)Google Scholar
  9. 9.
    Boggs, D. R.: Hematopoietic stem cell theory in relation to possible lymphoblastic conversion of chronic myeloid leukemia. Blood 44,499 (1974)Google Scholar
  10. 10.
    Sandberg, A. A., Hossfeld, D. K.: Chromosomal abnormalities in human neoplasia. Ann. Rev. Med. 21, 379 (1970)PubMedCrossRefGoogle Scholar
  11. 11.
    Fialkow. P. J.: Human myeloproliferative disorders: clonal origin in pluripotent stem cells. Proc. 5th Cold Spring Harbor Symposium (in press)Google Scholar
  12. 12.
    Fialkow, P.J., Denmon, A.M., Jacobson, R.J., Lowenthal, M.N.: Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells. J. Clin. Invest. 62, 815 (1978)PubMedCrossRefGoogle Scholar
  13. 13.
    Wintrobe, M.M., Lee, R.E., Boggs, D.R., Bithel, T., Athens, J.W., Foerster, J.: Clinical Hematology (7th edition). Philadelphia: Lea and Febiger 1974Google Scholar
  14. 14.
    Hoffman, R., Estren, S., Kopel, S., Marks, S.M., McCaffrey, R.P.: Lymphoblastic-like transformation of polycythemia vera. Ann. Intern. Med. 89, 71 (1978)PubMedGoogle Scholar
  15. 15.
    Chervenick, P.A., Ellis, L.D., Pan, S.F., Lawson, A.L.: Human leukemic cells: In vitro growth of colonies containing the Philadelphia (ph1) chromosome. Science 174, 1134 (1971)PubMedCrossRefGoogle Scholar
  16. 16.
    Whang-Peng, J., Lee, E., Knutsen, T., Chang, P., Nienhuis, A.: Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia. Leukemia Res. 2, 41 (1978)CrossRefGoogle Scholar
  17. 17.
    Srodes, C. H., Hyde, E. F., Pan, S.F., Chervenick, P. A., Boggs, D. R.: Cytogenetic studies during remission of blastic crisis in a patient with chronic myelocytic leukaemia. Scand. J. Haematol. 10, 130 (1973)PubMedCrossRefGoogle Scholar
  18. 18.
    Gall, J. A., Boggs, D.R., Chervenick, P. A., Pan, S. F., Fleming, R.B.: Discordant patterns of chromosomal changes and myeloblast proliferation during the terminal phase of chronic myeloid leukemia. Blood 47, 347 (1976)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • D. R. Boggs
    • 1
  1. 1.University of Pittsburgh, School of MedicinePittsburghUSA

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