Abstract
The effects of human leukemic blasts on normal in vitro granulocyte-macrophage colony-forming cells (CFU-C) [2,19] have been studied with conflicting results [4,5,8,9,11,13,18,25]. In some studies inhibition of normal human CFU-C by leukemic blasts was seen [4,5,13,18] while other studies failed to show inhibition [8,9,25]. These discordant results may, in part, result from histocompatibility differences as suggested by Bull et al. [4].
Preliminary reports of some of the observations in this paper appeared in abstract form in Blood 44, 952 (1974) and Exp. Hemat. 4, 84 (1976) (suppl.)
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Benestad, H. B.: Formation of granulocytes and macrophages in diffusion chamber cultures of mouse blood Leukocytes. Scand. J. Haematol. 7, 279–288 (1970)
Bradley, T.R., Metcalf, D.: The growth of mouse bone marrow cells in vitro. Aust. J. Exp. Biol. Med. Sci. 44, 287–300 (1966)
Bradlev, T. R., Sumner, M. A.: Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust. J. Exp. Biol. Med. Sci. 46, 607–618 (1968)
Bull, J.M., Rosenblum, A.L., Carbone, P.P.: In vitro culture studies in patients with acute myelocytic leukemia. Second International Workshop on Hematopoiesis in Culture. Robinson. W. A. (ed.). pp. 335–341. Washington. DC.: DHEW Publication No. (NIH) 74205 1973
Chiyoda, S., Mizoguchi, H., Kosaka, K. et al.: Influence of leukaemic cells on the colony formation of human bone marrow cells in vitro. Br. J. Cancer 31, 355–358 (1975)
Goldie, H., Butler, C. H., Anderson, M.M. et al.: Growth characteristics of free C1498 (Granulocytic Leukemia) tumor cells in the peritoneal fluid and the blood of C57 mice. Cancer Res. 14, 125–129 (1953)
Goldie, H., Jeffries, B.R., Green, S.S. et al.: Primary growth of leukemic cells as a factor in their lethal effect on the mouse. Cancer Res. 14, 423–427 (1954)
Goldman, J. M., Th’ng, K.H., Catovsky, D. et al.: Production of colony stimulating factor by leukemic leukocytes. Blood 47, 381–388 (1976)
Greenberg, P. L., Nichols, W.C., Schrier, S. L.: Granulopoiesis in acute myeloid leukemia and preleukemia. N. Engl. J. Med. 284, 1225–1232 (1971)
Handler, E. S., Handler, E. S., Bacon, E. R.: In vitro colony formation in bone marrow and spleen suspensions from rats with an acute myelogenous leukemia. J. Lab. Clin. Med. 81, 249–257 (1974)
Jacobson, N., Killman, S. A., Phillips, P. et al.: Interaction between normal and acute myeloblastic human bone marrow in diffusion chambers in mice. Exp. Hematol. 4, 190 (1976)
Kubanek, B., Tyler, W. S., Ferrari, L. et al.: Regulation of erythropoiesis XXI. The effect of erythropoietin on the stem cell. Proc. Soc. Exp. Biol. Med. 127, 770–776 (1968)
Kundtzon, S., Martensen, B.T.: Interaction between normal and leukaemic human cells in agar culture. Scand. J. Haematol. 17, 369–378 (1976)
Miller, A.M., Marmor, J. B., Page, P. L. et al.: Unregulated growth of murine leukemic cells and suppression of normal granulocyte growth in diffusion chamber cultures. Blood 47, 737–744 (1976)
Miller, A.M., Page, P.L., Hartwell, B.L. et al.: Inhibition of growth of normal murine granulocytes by cocultured acute leukemic cells. Blood 50, 799–809 (1977)
Miller, R.G., Phillips, R.A.: Separation of cells by velocity sedimentation. J. Cell. Physiol. 73, 191–201 (1969)
Moloney, W.C., McPherson, K., Fliegelman, L.: Esterase activity in leukocytes demonstrated with the use of Naphthal AS-D chloroacetate substrate. J. Histochem. Cytochem. 8, 200–207
Morris, T.C.M., McNeil, T.A., Bridges, J. M.: Inhibition of normal in vitro colony forming cells by cells from leukemic patients. Br. J. Cancer 31, 641–648 (1975)
Pluznik, D.H., Sachs, L.: The cloning of normal mast cells in tissue culture. J. Cell. Physiol. 66,319–324 (1965)
Quesenberry, P., Morley, A., Stohlman, F. Jr. et al.: Effect of endotoxin on granulopoiesis and colony stimulating factor. N. Engl. J. Med. 286, 227–232 (1972)
Quesenberry, P. J., Morley, A., Miller, M. et al.: Effect of endotoxin on granulopoiesis and the in-vitro colony-forming cell. Blood 41, 391–397 (1973)
Quesenberry, P., Niskanen, E., Symann, M. et al.: Growth of stem cell concentrates in diffusion chambers (DC). Cell Tissue Kinet. 7, 337–348 (1974)
Quesenberry, P., Halperin, J., Ryan, M. et al.: Tolerance to the granulocyte releasing and colony-stimulating factor elevating effects of endotoxin. Blood 45, 789–800 (1975)
Quesenberry, P., Rappeport, J., Fontebuoni, A., Sullivan, R., Zuckerman, K., Ryan, M.: Leukemic inhibition of normal murine hematopoiesis. N. Engl. J. Med. 299, 71–75 (1978)
Ragab, A.H., Gilkerson, E. S., Myers, M.L.: Granulopoiesis in childhood leukemia. Cancer 33, 791–797 (1974)
Robinson, W. A., Pike, B. L.: Colony growth of human marrow cells in vitro. In: Hemopoietic cellular proliferation. Stohlman, F. (ed.). pp. 249–259. New York, London: Grune and Stratton 1970
Till, J. E., McCulloch, E. A.: A direct measurement of the radiation sensitivity of normal bone marrow cells. Radiat. Res. 14,213–221 (1961)
Zuckerman, K., Sullivan, R., Quesenberry, P.: Effect of Actinomycin D in vivo on murine Erythroid Stem cells. Blood 51, 957–969 (1978)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Quesenberry, P.J. et al. (1979). Leukemic Inhibition of Normal Hematopoiesis. In: Neth, R., Gallo, R.C., Hofschneider, PH., Mannweiler, K. (eds) Modern Trends in Human Leukemia III. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67057-2_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-67057-2_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08999-5
Online ISBN: 978-3-642-67057-2
eBook Packages: Springer Book Archive