Skip to main content

Das Wiskott-Aldrich Syndrom

  • Conference paper

Part of the Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics book series (KINDERHEILK. NF,volume 41)

Zusammenfassung

Das klinische Bild und die Pathogeneseforschung des Wiskott-Aldrich Syndroms (WAS) sind aufgrund der charakteristischen Symptomentrias (thrombocytopenische Blutungen, gesteigerte Infektionsanfälligkeit, Ekzem) und des recessiv-geschlechtsgebundenen Erbganges nicht nur für den Pädiater von Interesse, sondern in gleichem Maß für den Hämatologen, Immunologen, Dermatologen und Genetiker (89, 106, 107, 113, 149, 152, 166, 191, 207, 222, 248, 260, 264, 265, 276, 286). Dennoch ist es, 40 Jahre nach der Erstbeschreibung, immer noch nicht gelungen, Ätiologie und Pathogenese des Syndroms zu klären. Damit fehlen auch weiterhin die Voraussetzungen für eine kausale Therapie und die eindeutige Abgrenzung von ähnlich verlaufenden Krankheiten.

Herr Prof. Dr. A. Wiskott zum 80. Geburtstag in Verehrung gewidmet.

Mit Unterstützung der Deutschen Forschungsgemeinschaft (Be 496/3)

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-67049-7_3
  • Chapter length: 100 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   54.99
Price excludes VAT (USA)
  • ISBN: 978-3-642-67049-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   69.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literaturverzeichnis

  1. Alagille, D.: Le syndrome d’Aldrich. In: Actualités Pédiatriques, 5. série, pp. 277–294. Paris: Doin 1963

    Google Scholar 

  2. Aldrich, R.A., Steinberg, A.G., Campbell, D.C.: Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13, 133–139 (1954)

    PubMed  CAS  Google Scholar 

  3. Altman, L.C., Snyderman, R., Blaese, R.M.: Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte Chemotaxis in Wiskott-Aldrich syndrome. J. clin. Invest. 54, 486–493 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  4. Alvarez-Amaya, C., Dorantes, S., Toro, A.H., Bello, A., Cuellar, J.: Forma atenuada del síndrome de Wiskott-Aldrich y la trascendencia de su identificación en el pronóstico de la esplenectomia. Bol. méd. Hosp. infant. (Méx.) 26, 633–647 (1969)

    Google Scholar 

  5. Alvarez-Amaya, C., Dorantes, S., Toro, A.H., Bello, A., Cuellar, J.: Attenuated form of Wiskott-Aldrich syndrome. J. Pediat. 82, 175–176 (1973)

    CrossRef  Google Scholar 

  6. Amiet, A.: Aldrich-Syndrom. Beobachtung zweier Fälle. Ann. paediat. (Basel) 201, 315–335 (1963)

    CAS  Google Scholar 

  7. Ammann, A.J., Hong, R.: Cellular Immunodeficiency Disorders. In: Immunologic Disorders in Infants and Children (Stiehm, E.R., Fulginiti, V.A., eds.), pp. 236–272. Philadelphia, London, Toronto: Saunders 1973

    Google Scholar 

  8. Andersen, V., Thomsen, M., Conn, J.: Immune deficiency in sex-linked hereditary thrombocytopenia. Acta path, microbiol. scand. (Sect. C) 83, 177–183 (1975)

    Google Scholar 

  9. Ascher, M.S., Gottlieb, A.A., Kirkpatrick, C.H.: Transfer Factor. Basic Properties and Clinical Applications. New York, San Francisco, London: Academic Press 1976

    Google Scholar 

  10. Ata, M., Fisher, O.D., Holman, CA.: Inherited thrombocytopenia. Lancet 1965 I, 119–123

    Google Scholar 

  11. August, C., Githens, J., Hathaway, W., Pearlman, D., Mcintosh, K.: Improvement in platelet function following bone marrow transplant in Wiskott-Aldrich syndrome. Clin. Res. 19, 210 (1971)

    Google Scholar 

  12. August, C.S., Hathaway, W.E., Githens, J.H., Pearlman, D., Mcintosh, K., Favara, B.: Improved platelet function following bone marrow transplantation in an infant with the Wiskott-Aldrich syndrome. J. Pediat. 82, 58–64 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  13. Ayoub, E.M., Dudding, B.A., Cooper, M.C: Dichotomy of antibody response to group A streptococcal antigens in Wiskott-Aldrich syndrome. J. Lab. clin. Med. 72, 971–979 (1968)

    PubMed  CAS  Google Scholar 

  14. Bach, F.H.: Persönliche Mitteilung, 1976

    Google Scholar 

  15. Bach, F.H., Albertini, R.J., Joo, P., Anderson, J.L., Bortin, M.M.: Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet 1968 II, 1364–1366

    Google Scholar 

  16. Baker, D.H., Parmer, E.A., Wolff, J.A.: Roentgen manifestation of the Aldrich syndrome. Amer. J. Roentgenol. 88, 458–465 (1962)

    CAS  Google Scholar 

  17. Baldini, M.G.: Platelet defect in Wiskott-Aldrich syndrome. New Engl. J. Med. 281, 107 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  18. Baldini, M.G.: Nature of the platelet defect in the Wiskott-Aldrich syndrome. Ann. N.Y. Acad. Sci. 201, 437–444 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  19. Baldini, M.G.: The Wiskott-Aldrich Syndrome. In: Birth Defects, Orig. Art. Ser. VIII/3, 151–157 (1972)

    Google Scholar 

  20. Baldini, M.G., Kim, B., Steiner, M., Kuramoto, A., Okuma, M., Otridge, B.W.: Metabolic platelet defect in the Wiskott-Aldrich syndrome. Ped. Res. 3, 377 (1969)

    Google Scholar 

  21. Ballow, M., Dupont, B., Good, R.A.: Autoimmune hemolytic anemia in Wiskott-Aldrich syndrome during treatment with transfer factor. J. Pediat. 83, 772–780 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  22. Ballow, M., Dupont, B., Hansen, J.L., Good, R.A.: Transfer Factor Therapy: Evidence for Nonspecificity. In: Birth Defects, Orig. Art. Ser. XI/1, 457–461 (1975)

    Google Scholar 

  23. Bandmann, HJ.: Wiskott-Aldrich-Syndrom. In: Handbuch der Haut- und Geschlechtskrankheiten, Vol. II/1. (A. Marchionini, ed.), pp. 355–357. Berlin, Göttingen, Heidelberg: Springer 1962

    Google Scholar 

  24. Barandun, S., Cottier, H., Riva, G.: Das Antikörpermangelsyndrom. Basel, Stuttgart: Schwabe 1959

    Google Scholar 

  25. Barsky, S., Momtaz, A.H.: Wiskott-Aldrich syndrome. Arch. Derm. 96, 730–731 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  26. Bartolozzi, G., Franchini, F.: Caratteristiche immunologiche del morbo di Aldrich. Minverva pediat. 19, 39–46 (1967)

    CAS  Google Scholar 

  27. Basten, A., Croft, S., Kenny, D.F., Nelson, D.S.: Uses of transfer factor. Vox Sang. (Basel) 28, 257–277 (1975)

    CAS  CrossRef  Google Scholar 

  28. Bean, S.F., South, M.A.: Cutaneous manifestations of immunogenetic deficiency disorders. J. invest. Derm. 60, 503–508 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  29. Belohradsky, B.H.: Das Wiskott-Aldrich-Syndrom. In: Pädiatrie in Klinik und Praxis (K. Bachmann et al., Hrsg.), 3 Bde. Stuttgart: Thieme und Fischer 1978, im Druck

    Google Scholar 

  30. Belohradsky, B.H., Finstad, J., Fudenberg, H.H., Good, R.A., Kunkel, H.G., Rosen, F.: Primary immunodeficiency diseases in man. Clin. Immunol. Immunpathol. 2, 281–295 (1974)

    CAS  CrossRef  Google Scholar 

  31. Belohradsky, B.H., Hennig, N., Marget, W., Fudenberg, H.H.: Adenosindesaminase-Mangel bei primären Immundefizienzen. Klin. Wschr. 54, 1109–1115 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  32. Bennich, H., Johansson, S.G.O.: Structure and function of human immunoglobulin E. Adv. Immunol. 13, 1–55 (1971)

    CAS  CrossRef  Google Scholar 

  33. Berglund, G., Finnström, O., Johansson, S.G.O., Möller, K.L.: Wiskott-Aldrich syndrome. A study of 6 cases with determination of the immunoglobulins A, D, G, M and ND. Acta paediat. scand. 57, 89–97 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  34. Bitar, J., Lightwood, R.: The Wiskott-Aldrich syndrome associated with mucoviscidosis in the same patient. J. Pediat. 71, 123–126 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  35. Blaese, R.M., Oppenheim, J.J., Seeger, R., Waldmann, T.A.: In vitro lymphocyte transformation: the restoration of purified lymphocyte responses by allogeneic macrophages from normal and anergic patients. Clin. Res. 18, 422 (1970)

    Google Scholar 

  36. Blaese, R.M., Oppenheim, J.J., Seeger, R.C., Waldmann, T.A.: Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy. Cell. Immunol. 4, 228–242 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  37. Blaese, R.M., Rosenberg, E., Wunderlich, J.: Evidence of two functionally distinct lymphocyte populations in man. Advanc. exp. Med. Biol. 29, 315–320 (1973)

    CAS  Google Scholar 

  38. Blaese, R.M., Strober, W., Brown, R.S., Waldmann, T.A.: The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition. Lancet 1968 I, 1056–1061

    Google Scholar 

  39. Blaese, R.M., Strober, W., Levy, A.L., Waldmann, T.A.: Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome. J. clin. Invest. 50, 2331–2338 (1971)

    PubMed  CAS  CrossRef  Google Scholar 

  40. Blaese, R.M., Strober, W., Waldmann, T.A.: Hypercatabolism of several serum proteins in the Wiskott-Aldrich syndrome. J. clin. Invest. 48, 8a (1969)

    Google Scholar 

  41. Blaese, R.M., Strober, W., Waldmann, T.A.: Immunodeficiency in the Wiskott-Aldrich Syndrome. In: Birth Defects, Orig. Art. Ser. XI/1, 250–254 (1975)

    Google Scholar 

  42. Blaese, R.M., Weiden, P., Oppenheim, J.J., Waldmann, T.A.: Phytohemagglutinin as a skin test for the evaluation of cellular immune competence in man. J. Lab. clin. Med. 81, 538–548 (1973)

    PubMed  CAS  Google Scholar 

  43. Blecher, T.E., Soothill, J.F., Voyce, M.A., Walker, W.H.C.: Antibody deficiency syndrome: A case with normal immunoglobulin levels. Clin. exp. Immunol. 3, 47–56 (1968)

    PubMed  CAS  Google Scholar 

  44. Bognár, I., Siegler, J., Miltényi, M.: Wiskott-Aldrich syndroma. Orv. Hetil. 108, 890–892 (1967)

    PubMed  Google Scholar 

  45. Brai, M., Balsamo, V., Mogavero, S., Romano, N., Lagrutta, A.: Sindrome di Wiskott-Aldrich. Descrizione di un caso. G. Batt. Immun. 68, 130–139 (1975)

    CAS  Google Scholar 

  46. Brand, M.M., Marinkovich, V.A.: Primary malignant reticulosis of the brain in Wiskott-Aldrich syndrome. Report of a case. Arch. Dis. Childh. 44, 536–542 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  47. Brubaker, C., Hammond, D.: Familial sex-linked thrombocytopenia: Response to splenectomy. Clin. Res. 7, 57 (1959)

    Google Scholar 

  48. Bruce, R.M., Blaese, R.M.: Monoclonal gammopathy in the Wiskott-Aldrich syndrome. J. Pediat. 85, 204–210 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  49. Buckley, R.H., Dees, S.C.: Correlation of milk precipitins with IgA deficiency. New Engl. J. Med. 281, 465–469 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  50. Buckley, R.H., Fiscus, S.A.: Serum IgD and IgE concentrations in immunodeficiency diseases. J. clin. Invest. 55, 157–165 (1975)

    PubMed  CAS  CrossRef  Google Scholar 

  51. Buneta, D., Raić, F., Bunarevic, A., Jurićić, D.: Klinika i patologija immunoloske insufidijencije s trombocitopenijom i ekcemom (syndroma Wiskott-Aldrich). Lijecn. Vjesn. 94, 131–138 (1972)

    CAS  Google Scholar 

  52. Burnet, F.M.: Transfer factor — a theoretical discussion. J. Allergy clin. Immunol. 54, 1–13 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  53. Canales, L., Mauer, A.M.: Sex-linked hereditary thrombocytopenia as a variant of Wiskott-Aldrich syndrome. New Engl. J. Med. 277, 899–901 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  54. Canales, L., Mauer, A.M.: Sex-linked recessive hereditary thrombocytopenia with immune globulin abnormalities. A form of Wiskott-Aldrich syndrome? Pediat. Res. 1, 216 (1967)

    CrossRef  Google Scholar 

  55. Caplin, J.A., Capriles, A., Straub, D.L., Neiburger, J.B., Wilkinson, J.H., Dockhorn, R.J.: Allergy in the Wiskott Aldrich syndrome: A case report. Ann. Allergy 39, 43–44 (1977)

    PubMed  CAS  Google Scholar 

  56. Cassimos, C., Anastasea-Vlahou, C., Kattamis, C., Kanavakis, E.: Aldrich’s syndrome (Thrombocytopenia, eczema, and recurrent infections). Amer. J. Dis. Child. 100, 914–917 (1960)

    PubMed  CAS  Google Scholar 

  57. Chaptal, J., Royer, P., Jean, R., Alagille, D., Bonnet, H., Lagarde, E., Robinet, M., Rieu, D.: Syndrome de Wiskott-Aldrich avec survie prolongee (9 ans). Evolution mortelle par thymosarcome. Arch. franc. Pediat. 23, 907–920 (1966)

    PubMed  CAS  Google Scholar 

  58. Chiaro, J.J., Dharmkrong-at, A.: X-linked thrombocytopenic purpura. I. Clinical and genetic studies of a kindred. Amer. J. Dis. Chil. 123, 565–568 (1972)

    CAS  Google Scholar 

  59. Chrzanowski, B., Gniot, E.: Zespól Wiskotta-Aldricha U 11- Miesiecznego niemowleçia. Pediat. pol. 41, 349–351 (1966)

    PubMed  CAS  Google Scholar 

  60. Claret, I., Morales, L., Montaner, A.: Immunological studies in the postsplenectomy syndrome. J. Pediat. Surg. 10, 59–64 (1975)

    PubMed  CAS  CrossRef  Google Scholar 

  61. Clinicopathological conference. A case of recurrent Kaposi’s varicelliform eruption. Brit. med. J. 1962 I, 315

    Google Scholar 

  62. Clinicopathologic conference. Rademacher’s disease. Diminished immunity of an unusual form complicated by lymphadenopathy. Amer. J. Med. 32, 80–95 (1962)

    Google Scholar 

  63. Coleman, A., Leikin, S., Guin, G.H.: Aldrich’s syndrome. Clin. Proc. Child. Hosp. (Wash.) 17, 22–27 (1961)

    CAS  Google Scholar 

  64. Cooper, M.D.: Functional deficiency of a B-cellsubline: Prime immunologic abnormality in the Wiskott-Aldrich syndrome? J. invest. Derm. 67, 431–434 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  65. Cooper, M.D., Chase, P., St. Gerne, jr., J.W., Krivit, W., Good, R.A.: Wiskott-Aldrich syndrome: A model of impaired defense mechanisms. J. Lab. clin. Med. 64, 849 (1964)

    Google Scholar 

  66. Cooper, M.D., Chase, H.P., Lowman, J.T., Krivit, W., Good, R.A.: Wiskott-Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity. Amer. J. Med. 44, 499–513 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  67. Cooper, M.D., Chase, H.P., Lowman, J.T., Krivit, W., Good, R.A.: Immunologic Defects in Patients with Wiskott-Aldrich syndrome. In: Birth Defects, Orig. Art. Ser. IV/1, 378–387 (1968)

    Google Scholar 

  68. Cooper, M.D., Faulk, W.P., Fudenberg, H.H., Good, R.A., Hitzig, W., Kunkel, H., Rosen, F.S., Seligmann, M., Soothill, J., Wedgwood, R.J.: Classification of primary immunodeficiencies. New Engl. J. Med. 288, 966–967 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  69. Cooper, M.D., Lawton, A.R.: Circulating B-cells in immunodeficiency. Amer. J. Path. 69, 513–528 (1972)

    PubMed  CAS  Google Scholar 

  70. Cummins, L., Searer, W., Levenson, S., Geppert, L.: Aldrich syndrome in twins. Amer. J. Dis. Child. 98, 579–580 (1959)

    Google Scholar 

  71. Dalloz, J.C., Castaing, N., Nezelof, C., Seligmann, M.: Paraprotéinémie transitoire de type gamma. Observation chez un nourrisson attaint du syndrome d’Aldrich. Presse méd. 73, 1541–1546 (1965)

    PubMed  CAS  Google Scholar 

  72. Danon, F., Seligmann, M.: Serum monoclonal immunoglobulins in childhood. Arch. Dis. Childh. 48, 207–211 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  73. David, J.L.: New platelet diseases. Acta med. scand. Suppl. 525, 185–188 (1971)

    PubMed  CAS  Google Scholar 

  74. Davis, S.: Hypothesis: Differentiation of the human lymphoid system based on cell surface markers. Blood 45, 871–880 (1975)

    PubMed  CAS  Google Scholar 

  75. Daxwanger, H.: Das Wiskott-Aldrich Syndrom. Multifaktorielle Analyse von 171 Fällen. Thesis, München 1977

    Google Scholar 

  76. De Graciansky, P., Guilaine, J.: Manifestations dermatologiques des hypo- et agamma-globulinémies. Bull. Soc. franc. Derm. Syph. 77, 654–665 (1970)

    PubMed  Google Scholar 

  77. De Graciansky, P., Schaison, G.: Le syndrome d’Aldrich. Ann. Derm. Syph. 94, 255–264 (1967)

    Google Scholar 

  78. Diamond, L.K.: Splenectomy in childhood and the hazard of overwhelming infection. Pediatrics 43, 886–889 (1969)

    PubMed  CAS  Google Scholar 

  79. Diaz-Buxo, J.A., Hermans, P.E., Ritts, R.E.: Wiskott-Aldrich syndrome inan adult. Mayo Clin. Proc. 49, 455–461 (1974)

    PubMed  CAS  Google Scholar 

  80. Dorantes-Mesa, S.: Observaciones sobre el diagnóstico de las enfermedades hemorragicas hereditarias. Gac.méd. Méx. 98, 1548–1557 (1968)

    PubMed  CAS  Google Scholar 

  81. Dorantes-Mesa, S.: Purpura trombocitopenica. Gac. méd. Méx. 100, 565–585 (1970)

    PubMed  CAS  Google Scholar 

  82. Doose, H.: Erkrankungen des Nervensystems. In: Kinderheilkunde (Harnack, G.A. von, Hrsg.), 4. Aufl., S. 331. Berlin, Heidelberg, New York: Springer 1977

    Google Scholar 

  83. Douglas, S.D., Fudenberg, H.H.: Graft versus host reaction in Wiskott-Aldrich syndrome: Antemortem diagnosis of human GVH in an immunologie deficiency disease. Vox Sang. (Basel) 16, 172–178 (1969)

    CAS  CrossRef  Google Scholar 

  84. Douglas, S.D., Goldberg, L.S.: Monocyte receptors for immunoglobulin and complement in immunologic deficiency diseases. Vox Sang. (Basel) 23, 214–217 (1972)

    CAS  CrossRef  Google Scholar 

  85. Doyle, C.T., Tempany, E., O’Donohoe, N.V.: The Wiskott-Aldrich syndrome. J. Irish med. Ass. 62, 104–106 (1969)

    CAS  Google Scholar 

  86. Dufier, J.L., Blanek, M.F., Renard, G., Polliot, L.: Syndrome de Wiskott-Aldrich et herpès cornéen récidivant. Ann. Oculist. (Paris) 208, 689–691 (1975)

    Google Scholar 

  87. Dupont, B., Ballow, M., Hansen, J.A., Quick, C., Yunis, E.J., Good, R.A.: Effect of transfer factor therapy on mixed lymphocyte culture reactivity. Proc. nat. Acad. Sci. (Wash.) 71, 867–871 (1974)

    CAS  CrossRef  Google Scholar 

  88. Editorial: Antenatal diagnosis of the haemoglobinopathies. Lancet 1977 I, 289–290

    Google Scholar 

  89. Editorial: Síndrome de Aldrich. Thrombopenia, eczema e infecciones recurrentes, de carácter familiar y curso en lactante varones. Actualid. Pediát. 19, 101–107 (1961)

    Google Scholar 

  90. Editorial: Symptom complexes, syndromes and eponyms. New Engl. J. Med. 277, 933 (1967)

    Google Scholar 

  91. Edson, J.R., Krivit, W., White, J.G.: Kaolin partial thromboplastine time: High levels of procoagulants producing short clotting times or masking deficiencies of other procoagulants or low concentrations of anticoagulants. J. Lab. clin. Med. 70, 463–470 (1967)

    PubMed  CAS  Google Scholar 

  92. Eitzman, D.V., Smith, R.T.: Immunologic studies on a patient with Aldrich’s syndrome. Sth. med. J. (Bgham, Ala.) 53, 1593 (1960)

    Google Scholar 

  93. Ekstedt, R.D., Hayes, L.L.: Runt diseases induced by non-living bacterial antigens. J. Immunol. 98, 110–118 (1967)

    PubMed  CAS  Google Scholar 

  94. Eraklis, A.J., Kevy, S.V., Diamond, L.K., Gross, R.E.: Hazard of overwhelming infection after splenectomy in childhood. New Engl. J. Med. 276, 1225–1229 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  95. Evans, D.I.K., Holzel, A.: Immune deficiency state in a girl with eczema and low serum IgM. Arch. Dis. Childh. 45, 527–533 (1970)

    PubMed  CAS  CrossRef  Google Scholar 

  96. Fanconi, G.: Das Säuglingsekzem. Praxis 49, 1–4 (1960)

    PubMed  CAS  Google Scholar 

  97. Faraci, R.P., Hoffstrand, J.H., Witebsky, F.G., Blaese, R.M., Beazley, R.M.: Malignant lymphoma of the jejunum in a patient with Wiskott-Aldrich syndrome. Surgical treatment. Arch. Surg. 110, 218–222 (1975)

    CAS  Google Scholar 

  98. Fassbinder, E.: Stammbaumuntersuchungen beim Wiskott-Aldrich-Syndrom. Thesis, Tübingen 1966

    Google Scholar 

  99. Faulk, W.P., Kiyasu, W.S., Cooper, M.D., Fudenberg, H.H.: Deficiency of IgM. Pediatrics, 47, 399–404 (1971)

    PubMed  CAS  Google Scholar 

  100. Finland, M.: Serious infections in splenectomized children. Pediatrics 27, 689–691 (1961)

    PubMed  CAS  Google Scholar 

  101. Flekova, M.: Das Wiskott-Aldrich-Syndrom. Mschr. Kinderheilk. 112, 299–306 (1964)

    PubMed  CAS  Google Scholar 

  102. Fontan, G., Garcia Rodriguez, M.C., Lorente, F., Ojeda, J.A.: Levamisole in Wiskott-Aldrich syndrome. Lancet 1976 II, 1247–1248

    Google Scholar 

  103. Freycon, F., Lauras, B., Bovier-Lapierre, F., Dorche, C., Goddon, R.: Anémie hémolytique congénitale par deficit en triosephosphate-isomérase. Pédiatrie 30, 55–65 (1976)

    Google Scholar 

  104. Fudenberg, H.H.: Genetically determined immune deficiency as the predisposing cause of “autoimmunity” and lymphoid neoplasia. Amer. J. Med. 51, 295–298 (1971)

    PubMed  CAS  CrossRef  Google Scholar 

  105. Fudenberg, H.H., Spitler, L.E., Levin, A.S.: Treatment of immune deficiency. Amer. J. Path. 69, 529–535 (1972)

    PubMed  CAS  Google Scholar 

  106. Fuhrmann, W.: Das Wiskott-Aldrich-Syndrom. Mschr. Kinderheilk. 113, 75 (1965)

    Google Scholar 

  107. Gatti, R.A., Good, R.A.: The immunological deficiency diseases. Med. Clin. N.Amer. 54, 281–307 (1970)

    PubMed  CAS  Google Scholar 

  108. Gatti, R.A., Good, R.A.: Occurrence of malignancy in immunodeficiency diseases. A literature review. Cancer (Philad.) 28, 89–98 (1971)

    CAS  CrossRef  Google Scholar 

  109. Gelfand, E.W., Baumal, R., Huber, J., Crookston, M.C., Shumak, K.H.: Polyclonal gammopathy and lymphoproliferation after transfer factor in severe combined immunodeficiency diesease. New Engl. J. Med. 289, 1385–1389 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  110. Gelzer, J., Gasser, C.: Beobachtungen an fünf Fällen von sog. Aldrich-Syndrom. Ann. paediat. (Basel) 196, 254–255 (1961)

    Google Scholar 

  111. Gelzer, J., Gasser, C.: Wiskott-Aldrich-Syndrom. Helv. paediat. Acta 16, 17–39 (1961)

    PubMed  CAS  Google Scholar 

  112. Gerety, R.J., Poplack, D.G., Hoofnagle, J.H., Blaese, R.M., Holland, P.V., Barker, L.F.: Hepatitis B virus infection in the Wiskott-Aldrich syndrome. J. Pediat. 88, 561–564 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  113. Germain, D.: Le syndrome d’Aldrich. Pediatrie 15, 603–605 (1960)

    PubMed  CAS  Google Scholar 

  114. Gershwin, M.E., Blaese, R.M., Steinberg, A.D., Wistar, jr., R., Strober, W.: Antibodies to nucleic acids in congenital immune deficiency states. J. Pediat. 89, 377–381 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  115. Gewurz, H., Pickering, J.R., Good, R.A.: Complement and complement component activities in diseases associated with repeated infections and malignancy. Int. Arch. Allergy 33, 368–388 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  116. Giblett, E.R., Ammann, AJ., Wara, D.S., Sandmann, R., Diamond, L.K.: Nucleoside Phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet 1975 I, 1010–1014

    Google Scholar 

  117. Gofstein, R., Gellis, S.S.: Splenectomy in infancy and childhood. The question of overwhelming infection following operation. Amer. J. Dis. Child. 91, 566–569 (1956)

    CAS  Google Scholar 

  118. Goldfinger, D., McGinniss, M.H.: RH-incompatible transfusions. Risks and consequences of sensitizing immunosuppressed patients. New Engl. J. Med. 284, 942–944 (1971)

    PubMed  CAS  CrossRef  Google Scholar 

  119. Goldmann, A.S., Anderson, D.W., Sellars, W.A., Saperstein, S., Kuiker, W.T., Halpern, S.R.: Milk allergy. I. Oral challenge with milk and isolated milk proteins in allergic children. Pediatrics 32, 425–433 (1963)

    Google Scholar 

  120. Good, R.A.: Editorial. Transfer factor. Cell. Immunol. 3, 1–4 (1972)

    CrossRef  Google Scholar 

  121. Gordon, R.R.: Aldrich’s syndrome: Familial thrombocytopenia, eczema and infection. Arch. Dis. Childh. 35, 259–265 (1960)

    PubMed  CAS  CrossRef  Google Scholar 

  122. Gotoff, S.P.: Lymphocytes in congenital immunological deficiency diseases. Clin. exp. Immunol. 3, 843–856 (1968)

    PubMed  CAS  Google Scholar 

  123. Grey, H.M., Rabellino, E., Pirofsky, B.: Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronoci lymphatic leukemia. J. clin. Invest. 50, 2368–2375 (1971)

    PubMed  CAS  CrossRef  Google Scholar 

  124. Griscelli, C.: Transfer Factor Therapy in Immunodeficiencies. In: Clinical Immunobiology (Bach, F.H., Good, R.A., eds.), Vol. 2, pp. 177–189. New York, London: Academic Press 1974

    Google Scholar 

  125. Griscelli, C.: Transfer Factor Therapy in Immunodeficiency. In: Birth Defects, Orig. Art. Ser. XI/1, 462–464 (1975)

    Google Scholar 

  126. Griscelli, C.: T and B Markers in Immunodeficiencies. In: Brith Defects, Orig. Art. Ser. XI/1, 45–46 (1975)

    Google Scholar 

  127. Griscelli, C., Phan-Huu-Trung, Herzog, C., Mozziconacci, P.: Le syndrome de Wiskott-Aldrich. Données récentes a propos de quatre observations. Nouv. Rév. franç. Hémat. 13, 554–568 (1973)

    PubMed  CAS  Google Scholar 

  128. Griscelli, C., Prieur, A.M., Daguillard, F.: Levamisol Therapy in Congenital Immunodeficiencies. In: Progress in Cancer Research and Therapy (Chirigos, M.A., ed.). New York: Raven (in press)

    Google Scholar 

  129. Griscelli, C., Revillard, J.P., Betuel, H., Herzog, C., Touraine, J.L.: Transfer factor therapy in immunodeficiencies. Rev. Europ. Etud. clin. Biol. 18, 220–227 (1973)

    CAS  Google Scholar 

  130. Griscelli, C., Williamson, C.: Le syndrome de Wiskott-Aldrich. Données récentes à propos de quatre observations. In: Journées Parisiennes de Pédiatrie, pp. 155–173 (1970).Paris: Ed. Médicales Flammarion 1970

    Google Scholar 

  131. Grob, P.J., Reymond, J.F., Häcki, M.A., Frey-Wettstein, M.: Some Physicochemical and Biological Properties of a Transfer Factor Preparation and Its Clinical Application. In: Transfer Factor. Basic Properties and Clinical Applications (Ascher, M.S., Gottlieb, A.A., Kirkpatrick, C.H., eds.), pp. 247–262. New York, San Francisco, London: Academic Press 1976

    Google Scholar 

  132. Gröttum, K.A., Hovig, T., Holmsen, H., Abrahamsen, A.F., Jeremic, M., Seip, M.: Wiskott-Aldrich syndrome: Qualitative platelet defects and short platelet survival. Brit. J. Haemat. 17, 373–388 (1969)

    PubMed  CrossRef  Google Scholar 

  133. Gröttum, K.A., Hovig, T., Holmsen, H., Nordøy, A.: Wiskott-Aldrich syndrome: Qaulitative platelet defects and short platelet survival. Blood 34, 542 (1969)

    Google Scholar 

  134. Gualdoni, C.: Un caso di morbo di Aldrich. Minerva nipiol. 12, 370–371 (1962)

    PubMed  CAS  Google Scholar 

  135. Gugler, E., Barandun, S.: Les manifestations pulmonaires du syndrome de carence en anticorps. J. franç. Méd. Chir. thor. 20, 201–205 (1966)

    PubMed  CAS  Google Scholar 

  136. Gupta, M.C., Agarwal, V.K., Mittal, A., Rajvanshi, V.S.: Wiskott-Aldrich syndrome (case report). J. Ass. Phycns India 12, 531–535 (1964)

    CAS  Google Scholar 

  137. Hadden, J.W., Holmes-Gray, B., Good, R.A.: Platelet abnormaüty in Wiskott-Aldrich syndrome. New Engl. J. Med. 283, 876–877 (1970)

    PubMed  CAS  Google Scholar 

  138. Hamet, M., Griscelli, C., Cartier, P., Ballay, J., deBruyn, C., Hösli, P.: A Second Case of Inosine Phosphorylase Deficiency With Severe T-cell Abnormalities. In: Purine Metabolism in Man, Vol. II, Advanc. exp. Med. Biol. 76A, 477–480 (1977)

    Google Scholar 

  139. Harzheim, J., Stechele, U., Künzer, W.: Zur Frage der disymptomatischen Form des Wiskott-Aldrich-Syndroms. Dtsch. med. Wschr. 90, 2047–2050 (1965)

    PubMed  CAS  CrossRef  Google Scholar 

  140. Hastrup, J., Grahl-Madsen, R.: Wiskott-Aldrich’s syndrome. Thrombocytopenia, eczema and recurrent infection. Dan. med. Bull. 12, 99–102 (1965)

    PubMed  CAS  Google Scholar 

  141. Hayakawa, H.: In vitro transformation of human peripheral blood lymphocytes. Jap. J. med. Sci. Biol. 24, 192–193 (1971)

    PubMed  CAS  Google Scholar 

  142. Heidelberger, K.P., LeGolvan, D.P.: Wiskott-Aldrich syndrome and cerebral neoplasia: Report of a case with localized reticulum cell sarcoma. Cancer (Philad.) 33, 280–284 (1974)

    CAS  CrossRef  Google Scholar 

  143. Heiner, D.C., Sears, J.W., Kniker, W.T.: Multiple precipitins to cow’s milk in chronic respiratory disease. Amer. J. Dis. Child. 103, 634–654 (1962)

    PubMed  CAS  Google Scholar 

  144. Hellem, A.J.: Metabolic disorders of platelets. Advanc. intern. Med. 17, 171–187 (1971)

    CAS  Google Scholar 

  145. Heyn, R.M., Tubergen, D.G., Althouse, N.T.: Lymphocyte size distribution. Determination in normal children and adults and in patients with immunodeficiency states. Amer. J. Dis. Child. 125, 789–793 (1973)

    PubMed  CAS  Google Scholar 

  146. Hitzig, W.H.: Der Transfer-Faktor und seine therapeutische Bedeutung. Blut 27, 145–150 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  147. Hitzig, W.H., Fontanellaz, H.P., Müntener, U., Paul, S., Spitler, L.E., Fudenberg, H.H.: Transfer factor. Immunologische Grundlagen und therapeutische Erfahrungen. Schweiz. med. Wschr. 102, 1237–1244 (1972)

    PubMed  CAS  Google Scholar 

  148. Hitzig, W.H., Grob, P.J.: Therapeutic Uses of Transfer Factor. In: Progress in Clinical Immunology, Vol. 2, pp. 69–100 (Schwartz, R.S., ed.). New York: Grune & Stratton 1974

    Google Scholar 

  149. Hjelt, L.: The Wiskott-Aldrich’s syndrome. An immunopathy. Acta paediat. scand. Suppl. 159, 109 (1965)

    CrossRef  Google Scholar 

  150. Holt, L.E.: Conference on infantile eczema. Immunologic responses in infantile eczema. J. Pediat. 66, 224–234 (1965)

    CrossRef  Google Scholar 

  151. Hong, R., West, CD., Holland, N.H.: Immunoglobulin levels in infants and children: Effects of age and disease. J. Pediat. 61, 301–302 (1962)

    PubMed  CAS  CrossRef  Google Scholar 

  152. Horowitz, S.D., Hong, R.: The pathogenesis and treatment of immunodeficiency. Monogr. Allergy 10, 1–198 (1977)

    CAS  Google Scholar 

  153. Houštěk, J., Hrodek, O., Rádl, J., Libánská, J.: Změny sérovŷch bílkovin a jemné morfologie destiček u Wiskottova-Aldrichova syndromu. Čas. Lék. čes. 105, 1047–1052 (1966)

    Google Scholar 

  154. Howley, P.M., Khoury, G., Byrne, J.C., Takemoto, K.K., Martin, M.A.: Physical map of the BK virus genome. J. Urol. 16, 959–964 (1975)

    CAS  Google Scholar 

  155. Huber, J.: Experience With Various Immunologic Deficiencies in Holland. In: Birth Defects, Orig. Art. Ser. IV/1, 53–66 (1968)

    Google Scholar 

  156. Huber, H., Fudenberg, H.H.: Die immunologische Funktion von Monozyten und Makrophagen. Klin. Wschr. 47, 1061–1068 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  157. Hunter, A., Feinstein, A., Coombs, R.R.A.: Immunoglobulin class of antibodies to cow’ milk casein in infant sera and evidence for low molecular weight IgM antibodies. Immunology 15, 381–388 (1968)

    PubMed  CAS  Google Scholar 

  158. Huntley, C.C.: Infection following splenectomy in infants and children. Amer. J. Dis. Child. 95, 477–480 (1958)

    CAS  Google Scholar 

  159. Huntley, C.C., Dees, S.C.: Eczema associated with thrombocytopenic purpura and purulent otitis media. Pediatrics 19, 351–361 (1957)

    PubMed  CAS  Google Scholar 

  160. Huntley, C.C., Robbins, J.B., Lyerly, A.D., Buckley, R.H.: Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency. New Engl. J. Med. 284, 7–10 (1971)

    PubMed  CAS  CrossRef  Google Scholar 

  161. Iacovacci, G., Ungari, S., Aiuti, F.: Aspetti immunologici della sindrome di Aldrich. Minerva stomat. 42, 421 (1967)

    CAS  Google Scholar 

  162. Iio, A., Strober, W., Broder, S., Polmar, S.H.: The metabolism of IgE in patients with immunodeficiency states and neoplastic conditions. J. clin. Invest. 59, 743–755 (1977)

    PubMed  CAS  CrossRef  Google Scholar 

  163. Javier, G., Tusell, J., Compte, J., Saenz, A., Ortega, J.J.: Syndrome de Wiskott-Aldrich. A propos de 3 cas dans unse même famille. Nouv. Rev. franc. Hemat. 18, 182–184 (1977)

    CAS  Google Scholar 

  164. Jørgensen, H.P.: Nonfatal Wiskott-Aldrich syndrome in a 15-year-old boy. Arch. Derm. 106, 541–542 (1972)

    PubMed  CrossRef  Google Scholar 

  165. Johnson, G.M., Burke, E.C., Burgert, E.O.: Wiskott-Aldrich syndrome: Report of an additional case. Mayo Clin. Proc. 39, 258–262 (1964)

    PubMed  CAS  Google Scholar 

  166. Josso, F.: Le syndrome d’Aldrich. Arch, franç. Pédiat. 21, 114–117 (1964)

    Google Scholar 

  167. Kalus, M., Holub, J.: Aldrich-Wiskott-Syndrome with thrombocytophagy and lipopigment in the reticuloendothelial system. Folia haemat. 86, 164–173 (1966)

    CAS  Google Scholar 

  168. Kaplan, E.: Congenital and neonatal thrombocytopenic purpura. A review. J. Pediat. 54, 644–653 (1959)

    CAS  Google Scholar 

  169. Kastrup, A.K.W.: Wiskott-Aldrich syndromet. En oversigt og 2 egne tilfaelde. Ugeskr. Laeg. 127, 765–768 (1965)

    Google Scholar 

  170. Keiser, H.D., Kushner, I.: Blasts in Wiskott-Aldrich syndrome. Lancet 1967 II, 836

    Google Scholar 

  171. Kersey, J.H., Spector, B.D., Good, R.A.: Primary immunodeficiency and cancer: The immunodeficiency-cancer registry. Int. J. Cancer 12, 333–347 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  172. Kersey, J.H., Spector, B.D., Good, R.A.: Cancer in children with primary immunodeficiency diseases. J. Pediat. 84, 263–264 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  173. Kersey, J.H., Spector, B.D., Good, R.A.: Primary Immunodeficiency and Malignancy. In: Birth Defects, Orig. Art. Ser. XI/1, 289–298 (1975)

    Google Scholar 

  174. Khan, A., Sellars, W., Goble, P., Hill, J.M.: The Role of Transfer Factor in the Treatment of Lymphoma Cutis in Wiskott-Aldrich Syndrome. In: Transfer Factor. Basic Properties and Clinical Applications (Ascher, M.S., Gottlieb, A.A., Kirkpatrick, C.H., eds.), pp. 595–600. New York, San Francisco, London: Aca Academic Press 1976

    Google Scholar 

  175. Khan, A., Sellars, W.A., Goble, P., Thomek, D.: Transfer factor, thymosin, and E-rosettes. New Engl. J. Med. 292, 868 (1975)

    PubMed  CAS  CrossRef  Google Scholar 

  176. Kiesewetter, W.B.: Pediatric splenectomy. Indications, technique, compHcations, and mortality. Surg. Clin. N. Amer. 55, 449–460 (1975)

    PubMed  CAS  Google Scholar 

  177. Kildeberg, P.: The Aldrich syndrome. Report of a case and discussion of pathogenesis. Pediatrics 27, 362–369 (1961)

    PubMed  CAS  Google Scholar 

  178. Kildeberg, P.: A case of Aldrich’s syndrome. Acta paediat. scand. 52 (Suppl. 140), 120–121 (1961)

    Google Scholar 

  179. Kim, B.K., Kuramoto, A., Steiner, M., Baldini, M.G.: Platelet glycolysis in the Wiskott-Aldrich syndrome. Blood 34, 542–543 (1969)

    Google Scholar 

  180. King, H., Shumacker, H.B.: Splenic studies. I. Susceptibility to infection after splenectomy performed in infancy. Ann. Surg. 136, 239–242 (1952)

    PubMed  CAS  CrossRef  Google Scholar 

  181. Koch, F.: Konstitutionelle Abwehrschwächen unter besonderer Berücksichtigung des ersten Lebensjahres. Med. Welt 40, 2055–2061 (1961)

    PubMed  CAS  Google Scholar 

  182. Kouvalainen, K., Backman, A., Rethijärvi, K.: Chronic moniliasis, pyoderma and impaired capacity to form Gamma-M antibodies. Ann. Paediat. Fenn. 12, 256–262 (1966)

    PubMed  CAS  Google Scholar 

  183. Krivit, W., Good, R.A.: Aldrich’s syndrome (Thrombocytopenia, eczema, and infection in infants). Studies of the defense mechanisms. Amer. J. Dis. Child. 97, 137–153 (1959)

    CAS  Google Scholar 

  184. Krivit, W., Yunis, E., White, J.G.: Platelet survival studies in Aldrich syndrome. Pediatrics 37, 339–341 (1966)

    PubMed  CAS  Google Scholar 

  185. Kuramoto, A., Steiner, M., Baldini, M.G.: Lack of platelet response to stimulation in the Wiskott-Aldrich syndrome. New Engl. J. Med. 282, 475–479 (1970)

    PubMed  CAS  CrossRef  Google Scholar 

  186. Landolt, R.F.: Kongenitale (neonatale) Thrombopenien. Helv. paediat. Acta 1 (Helv. med. Acta-Series D), 3–16 (1948)

    Google Scholar 

  187. Lanzkowsky, P., Levy, S.: The triad of thrombocytopenia, eczema and infection (Wiskott-Aldrich’s syndrome). S. Afr. med. J. 39, 280–282 (1965)

    PubMed  CAS  Google Scholar 

  188. Laroye, G.J.: How efficient is immunological surveillance against cancer and why does it fail? Lancet 1974 I, 1097–1100

    Google Scholar 

  189. Lawrence, H.S.: Selective Immunotherapy With Transfer Factor. In: Clinical Immunobiology (F.H. Bach, R.A. Good, eds.), Vol. 2, pp. 115–152. New York, London: Academic Press 1974

    Google Scholar 

  190. Lawrence, H.S.: Transfer Factor. Basic Properties and Clinical Applications (Ascher, M.S., Gottlieb, A.A., Kirkpatrick, C.H., eds., pp. 741–753. New York, San Francisco, London: Academic Press 1976

    Google Scholar 

  191. Leading Article: Significance of the Wiskott-Aldrich syndrome. Brit. med. J. 1968 II, 66–67

    Google Scholar 

  192. Lechner, K., Stockinger, L., Graf, J.: Eleketronenmikroskopische Untersuchungen an Thrombozyten von Patienten mit Thrombopathien. In: Thrombozytäre Gerinnungsstörungen (Zuckerschwerdt, H., Hrsg.), S. 175–194. Stuttgart: Schattauer 1967

    Google Scholar 

  193. Levin, A.S., Spitler, L.E., Fudenberg, H.H.: Transfer factor therapy in immune deficiency states. Ann. Rev. Med. 175–208 (1973)

    Google Scholar 

  194. Levin, A.S., Spitler, L.E., Stites, D.P., Fudenberg, H.H.: Wiskott-Aldrich syndrome, a genetically determined cellular immunologic deficiency: Clinical and laboratory responses to therapy with transfer factor. Proc. nat. Acad. Sci. (Wash.) 67, 821–828 (1970)

    CAS  CrossRef  Google Scholar 

  195. Lindberg, T., Palmgren, B.: Wiskott-Aldrich-Syndrom: Thrombozytopenie, Ekzem sowie Neigung zu Infektionen. Arch. Kinderheilk. 166, 164–174 (1962)

    PubMed  CAS  Google Scholar 

  196. Lobitz, W.C., Honeyman, J.F., Winkler, N.W.: Suppressed cell-mediated immunity in two adults with atopic dermatitis. Brit. J. Derm. 86, 317–322 (1972)

    PubMed  CrossRef  Google Scholar 

  197. Mandl, M.A.J., Watson, J.I., Rose, B.: The Wiskott-Aldrich syndrome. Immunopathologic mechanisms and a long-term survival. Ann. intern. Med. 68, 1050–1059 (1968)

    Google Scholar 

  198. Marchal, G., Bilski-Pasquier, G., Bonnet-Gajdos, M., Samama, M.: Le syndrome d’Aldrich. Purpura thrombopénique familial, eczéma, infections récidivantes. Presse méd. 71, 2621–2625 (1963)

    PubMed  CAS  Google Scholar 

  199. Marinkovich, V.A.: Immunological studies in Wiskott-Aldrich syndrome. Clin. Res. 19, 211 (1971)

    Google Scholar 

  200. Marinkovich, V.A.: The in vitro response of peripheral blood lymphocytes from patients with Wiskott-Aldrich syndrome. Clin. Allergy 2, 69–78 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  201. Marshall, W.C., Cope, W.A., Soothill, J.F., Dudgeon, J.A.: In vitro lymphocyte response in some immunity deficiency diseases and in intrauterine virus infections. Proc. roy. Soc. Med. 63, 351–354 (1970)

    PubMed  CAS  Google Scholar 

  202. Mason, D.H., Takemoto, K.K.: Complementation between BK human papoavirus and a simian virus 40 TSA mutant. J. Virol. 17, 1060–1062 (1976)

    PubMed  CAS  Google Scholar 

  203. Mauer, A.M.: X-linked recessive disorders: Chronic granulomatous disease and Wiskott-Aldrich syndrome J. Invest. Derm. 60, 522–528 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  204. McEnery, G., Nash, F.W.: Wiskott-Aldrich syndrome associated with idiopathic infantile cortical hyperostosis (Caffey’s disease). Arch. Dis. Childh. 48, 818–821 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  205. Midulla, M.: Porpora trombocitopenica associata ad eczema ed infezioni in tre bambini di sesso maschile apparteneti ad una stessa famiglia (sindrome di Aldrich). Arch. ital. Pediat. 20, 264–271 (1959)

    Google Scholar 

  206. Mihan, R.: Variant of Aldrich’s syndrome. Arch. Derm. 92, 742 (1965)

    Google Scholar 

  207. Millikan, M.E.: Wiskott Aldrich syndrome: A treatable immune disorder. Missouri Med. 70, 764–767 (1973)

    PubMed  CAS  Google Scholar 

  208. Mills, S.D., Winkelmann, R.K.: Eczema, thrombocytopenic purpura, and recurring infections. A familial disorder with report of four families. Arch. Derm. 79, 466–472 (1959)

    CAS  Google Scholar 

  209. Moreli, A., Skvaril, F., Rádl, J., Dooren, L.J., Barandun, S.: IgG-subclass Abnormalities in Primary Immunodeficiency Diseases. In: Birth Defects, Orig. Art. Ser. XI/1, 108–111 (1975)

    Google Scholar 

  210. Moretta, L., Mingari, M.C., Webb, S.R., Pearl, E.R., Lydyard, P.M., Grossi, C.E., Lawton, A.R., Cooper, M.D.: Imbalance in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. Europ. J. Immunol. 7, 696–700 (1977)

    CAS  CrossRef  Google Scholar 

  211. Moretta, L., Webb, S.R., Grossi, C.E., Lydyard, P.M., Cooper, M.D.: Functional analysis of two human T-cell subpopulations: Help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG. J. exp. Med. 146, 184–200 (1977)

    PubMed  CAS  CrossRef  Google Scholar 

  212. Moser, K., Fischer, M., Krepier, P., Lechner, K.: Glutathionreduktase- und Triosephosphatisomerasemangel in Erythrozyten und Thrombozyten bei Pancytopenie (Typ Estren-Damashek). Klin. Wschr. 46, 995–997 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  213. Moynahan, E.J.: Wiskott-Aldrich syndrome (eczema, recurrent bleeding and recurrent upper respiratory infections). Proc. roy. Soc. Med. 55, 232–233 (1962)

    PubMed  CAS  Google Scholar 

  214. Murphy, S.: Intrinsic platelet defects in hereditary thrombocytopenia. Ann. N.Y. Acad. Sci. 201, 421–428 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  215. Murphy, S., Oski, F.A., Gardner, F.H.: Hereditary thrombocytopenia with an intrinsic platelet defect. New Engl. J. Med. 281, 857–862 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  216. Murphy, S., Oski, F.A., Naiman, J.L., Lusch, C.J., Goldberg, S., Gardner, F.H.: Platelet size and kinetics in hereditary and acquired thrombocytopenia. New Engl. J. Med. 286, 499–504 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  217. Musumeci, S., D’Agata, A., Di Gregorio, L.: La soprawivenza delle piastrine e del fibrinogeno in un caso di sindrome di Wiskott-Aldrich. Pediatria (Napoli) 81, 490–501 (1973)

    CAS  Google Scholar 

  218. Nathan, D.G., Oski, F.A.: Hematology of Infancy and Childhood. Philadelphia, London, Toronto: Saunders 1974

    Google Scholar 

  219. Neidhart, J.A., Schwartz, R.S., Hurtubise, P.E., Murphy, S.G., Metz, E.N., Balcerzeak, S.P., LoBuglio, A.F.: Transfer factor: Isolation of a biologically active component. Cell. Immunol. 9, 319–323 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  220. Nelson, D.S.: Immunobiology of the Macrophage. New York, San Francisco, London: Academic Press 1976

    Google Scholar 

  221. Newcomb, R.W., Ishizaka, K.: Skin reactions to anti-7 E antibody in atopic, nonatopic, and immunologically deficient children and adults. J. Allergy 43, 292–300 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  222. Nezelof, C.: Classification des maladies immuno-deficitaires. Arch, franc. Pediat. 25, 781–825 (1968)

    CAS  Google Scholar 

  223. Niordson, A.-M., Schmidt, H.: Aldrich’s syndrome. A report of two cases. Arch. Derm. 88, 613–615 (1963)

    PubMed  CAS  Google Scholar 

  224. Ochs, H.D., Ament, M.E., Davis, S.D.: Structure and Function of the Gastrointestinal Tract in Primary Immunodeficiency Syndromes (IDS) and in Granulocyte Dysfunction. In Brith Defects, Orig. Art. Ser. XI/1, 199–207 (1975)

    Google Scholar 

  225. Oppenheim, J.J., Blaese, R.M., Horton, J.E., Thor, D.E., Granger, G.A.: Production of macrophage migration inhibitory factor and lymphotoxin by leukocytes from normal and Wiskott-Aldrich syndrome patients. Cell. Immunol. 8, 62–70 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  226. Oppenheim, J.J., Blaese, R.M., Waldmann, T.A.: Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome. J. Immunol. 104, 835–844 (1970)

    PubMed  CAS  Google Scholar 

  227. Østergaard, P.A.: A girl with recurrent infections, low IgM and an abnormal chromosome number 1. Acta paediat. scand. 62, 211–215 (1973)

    PubMed  CrossRef  Google Scholar 

  228. Page, A.R., Hansen, A.E., Good, R.A.: Occurrence of leukemia and lymphoma in patients with agammaglobulinemia. Blood 21, 197–206 (1963)

    PubMed  CAS  Google Scholar 

  229. Palmgren, B., Lindberg, T.: Immunological studies in Wiskott-Aldrich syndrome. Acta paediat (Uppsala) Suppl. 146, 166–121 (1963)

    Google Scholar 

  230. Pearson, H.A., Shulman, N.R., Oski, F.A., Eitzman, D.V.: Platelet studies in Wiskott-Aldrich syndrome. J. Pediat. 67, 955–956 (1965)

    CrossRef  Google Scholar 

  231. Pearson, H.A., Shulman, N.R., Oski, F.A., Eitzman, D.V.: Platelet survival in Wiskott-Aldrich syndrome. J. Pediat. 68, 754–760 (1966)

    PubMed  CAS  CrossRef  Google Scholar 

  232. Penn, I.: Occurrence of cancer in immune deficiencies. Cancer (Philad.) 34, 858–866 (1974)

    CrossRef  Google Scholar 

  233. Perry, G.S.: Persönliche Mitteilung, 1977

    Google Scholar 

  234. Peterson, R.D.A.: Antibodies to the proteins in cow’s milk. Fed. Proc. 21, 23 (1962)

    Google Scholar 

  235. Pham-Huu-Trung, Griscelli, C., Mozziconacci, P.: Ultrastructure des plaquettes sanguines dans le syndrome de Wiskott-Aldrich. Path, et Biol. 23, 57–62 (1975)

    Google Scholar 

  236. Pierson, M., Lascombes, G., Manciaux, M.: Syndrome d’Aldrich. Ann. Pediat. 36, 458–460 (1960)

    Google Scholar 

  237. Podos, S.M., Einaugler, R.B., Albert, D.M., Blaese, R.M.: Ophthalmie manifestations of the Wiskott-Aldrich syndrome. Arch. Ophthal. 82, 322–329 (1969)

    PubMed  CAS  Google Scholar 

  238. Preud’Homme, J.L., Griscelli, C., Seligmann, M.: Immunoglobulins on the surface of lymphocytes in fifty patients with primary immunodeficiency diseases. Clin. Immunol. Immunopath. 1, 241–256 (1973)

    CrossRef  Google Scholar 

  239. Rachelefsky, G.S., McConnachie, P.R., Ammann, A.J., Terasaki, P.I., Stiehm, E.R.: Antibody-dependent lymphocyte killer function in human immunodeficiency diseases. Clin. exp. Immunol. 19, 1–9 (1975)

    PubMed  CAS  Google Scholar 

  240. Radl, J., Dooren, L.J., Moreli, A., Skvaril, F., Vossen, J.M.J.J., Uittenbogaart, C.H.: Immunoglobulins and transient paraproteins in sera of patients with the Wiskott-Aldrich syndrome: A follow-up study. Clin. exp. Immunol. 25, 256–263 (1976)

    PubMed  CAS  Google Scholar 

  241. Radl, J., Masopust, J., Houstek, J., Hrodek, O.: Paraproteinaemia and unusual Dys-γ-globulinaemia in a case of Wiskott-Aldrich syndrome. Arch. Dis. Childh. 42, 608–614 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  242. Ravin, M.B.: Anesthetic management of Wiskott-Aldrich syndrome. Anesthesiology 27, 199–201 (1966)

    CrossRef  Google Scholar 

  243. Rhodes, K., Markham, R.L., Maxwell, P.M., Monk-Lones, M.E.: Immunoglobulins and the X-chromosome. Brit. med. J. 1969 III, 439–441

    Google Scholar 

  244. Rivera, A.M., Biehusen, F.C.: Aldrich’s syndrome. Report of a case with subperiosteal hemorrhage. J. Pediat. 57, 86–88 (1960)

    PubMed  CAS  CrossRef  Google Scholar 

  245. Rola-Plesczcynski, M., Frenkel, L.D., Bellanti, J.A.: Combined immunodeficiency and transfer factor. J. Pediat. 86, 818–819 (1975)

    CrossRef  Google Scholar 

  246. Root, A.W., Speicher, CE.: The triad of thrombocytopenia, eczema, and recurrent infections (Wiskott-Aldrich syndrome) associated with milk antibodies, giant-cell pneumonia, and cytomegalic inclusion disease. Pediatrics 31, 444–454 (1963)

    PubMed  CAS  Google Scholar 

  247. Rosen, F.S.: Primary immunodeficiency. Pediat. Clin. N. Amer. 21, 533–549 (1974)

    PubMed  CAS  Google Scholar 

  248. Rosen, F.S.: Immunodeficiency. In: Immunogenetics and Immunodeficiency (Benacerraf, B., ed.), pp. 229–257. London, Colchester, Beccles: Clowes 1975

    Google Scholar 

  249. Rosen, F.S.: The primary immunodeficiencies: Dermatologie manifestations. J. invest. Derm. 67, 402–411 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  250. Rossi, E.C., Green, D.: Disorders of platelet function. Med. Clin. N. Amer. 56, 35–46 (1972)

    PubMed  CAS  Google Scholar 

  251. Rostenberg, A., Solomon, L.M.: Infantile eczema and systemic disease. Arch. Derm. 98, 41–46 (1968)

    PubMed  CrossRef  Google Scholar 

  252. Rowell, N.R.: Dermatological manifestations of the immunity deficiency syndromes. Brit. J. Derm. 80, 618–620 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  253. Rubin, A.D., Johnson, L.I., Brown, S.M.: Lymphocyte proliferation and lymphoproliferative disorders. Progr. exp. Tumor Res. (Basel) 13, 135–180 (1970)

    CAS  Google Scholar 

  254. Rudkowski, Z.: Zagadnienia kliniczne dotycz’ace wrodzonych zespo ow upo’ sledzoneij odprono’sci immunologiczneij. Pediat. pol. 52, 803–808 (1977)

    PubMed  CAS  Google Scholar 

  255. Rziha, H.J., Belohradsky, B.H., Schneider, U., Schwenk, H.U., Bornkamm, G.W., zur Hausen, H.: BK Virus: II. Serological studies in children with malignant tumors and primary immunodeficiencies. Med. Microbiol. Immunol. 165, 83–99 (1978)

    PubMed  CAS  CrossRef  Google Scholar 

  256. Sansone, G.: Porpora trombopenica del lattante associata a malformazioni multiple ed a spiccata suscettibilita alle infezioni. Rapporti con la sindrome di Aldrich. Minerva pediat. 10, 677–684 (1958)

    PubMed  CAS  Google Scholar 

  257. Schaar, F.E.: Familial idiopathic thrombocytopenic purpura. J. Pediat. 62, 546–551 (1963)

    PubMed  CAS  CrossRef  Google Scholar 

  258. Scher, R.K.: Wiskott-Aldrich syndrome. Cutis 12, 566–569 (1973)

    Google Scholar 

  259. Scheurlen, P.G., Schneider, W., Klemm, D., Gross, R.: Monoklonale (L-Ketten-) Gammopathie mit Riesenplättchen-Thrombocytopathie. Ein kombinierter genetischer Defekt? Klin. Wschr. 48, 699–701 (1970)

    CAS  CrossRef  Google Scholar 

  260. Schreiber, G.: Le syndrome de Wiskott-Aldrich. Presse med. 51, 3090 (1964)

    Google Scholar 

  261. Schubert, W.K., Fowler jr., R., Martin, L.W., West, C.D.: Homograft rejection in children with congenital immunological defects: Agammaglobulinemia and Aldrich syndrome. Plast. reconstr. Surg. 26, 125–128 (1960)

    CAS  CrossRef  Google Scholar 

  262. Schulman, I.: Clinical Disorders of the Platelets. In: Hematology of Infancy and Childhood (Nathan, D.G., Oski, F.A., eds.), pp. 639–661. Philadelphia, London, Toronto: Saunders 1974

    Google Scholar 

  263. Schwenk, H.U., Gimpert, E., Plüss, H.J., Pilgrim, U., Hitzig, W.H.: Lymphocyte markers for B- and T-cells in primary immunodeficiency diseases. Klin. Wschr. 52, 426–432 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  264. Seligmann, M., Schaison, G.: Le syndrome de Wiskott-Aldrich. Ent. Bichat. Medecine 497–499 (1969)

    Google Scholar 

  265. Sell, S.: Immunological deficiency diseases. Arch. Path. 86, 95–107 (1968)

    PubMed  CAS  Google Scholar 

  266. Sellars, W.A., South, M.A.: Wiskott-Aldrich syndrome with 18-year survival. Treatment with transfer factor. Amer. J. Dis. Child. 129, 622–627 (1975)

    PubMed  CAS  Google Scholar 

  267. Shabalov, N.P., Rokhlenko, E., Kazban, N.: Sindrom Viskotta-Oldricha. Pediatriya 53, 78–83 (1974)

    Google Scholar 

  268. Sherwood, G., Blaese, R.M.: Phytohaemagglutinin-induced cytotoxic effector lymphocyte function in patients with the Wiskott-Aldrich syndrome (WAS). Clin. exp. Immunol. 13, 515–520 (1973)

    PubMed  CAS  Google Scholar 

  269. Sheth, N.K., Prankerd, T.A.J.: Inherited thrombocytopenia with thrombasthenia. J. clin. Path. 21, 154–156 (1968)

    PubMed  CAS  CrossRef  Google Scholar 

  270. Sixma, J.J., Wester, J.: The hemostatic plug. Semin. hemat. 14, 265–299 (1977)

    PubMed  CAS  Google Scholar 

  271. Snyderman, R., Mergenhagen, S.E.: Chemotaxis of Macrophages. In: Immuno-biology of the Macrophage (Nelson, D.S., ed.), pp. 323–348. New York, San Francisco, London: Academic Press 1976

    Google Scholar 

  272. Spector, B.D.: Persönliche Mitteilung, 1976

    Google Scholar 

  273. Spitler, L.E., Levin, A.S., Fudenberg, H.H.: Transfer Factor. In: Clinical Immuno-biology (Bach, F.H., Good, R.A., eds.), Vol. 2, pp. 153–175. New York, London: Academic Press 1974

    Google Scholar 

  274. Spitler, L.E., Levin, A.S., Fudenberg, H.H.: Transfer Factor. II. Results of Therapy. In: Birth Defects, Orig. Art. Ser. XI/1, 449–456 (1975)

    Google Scholar 

  275. Spitler, L.E., Levin, A.S., Stites, D.P., Fudenberg, H.H.: Current status of transfer factor therapy in Wiskott-Aldrich syndrome. Clin. Res. 19, 162 (1971)

    Google Scholar 

  276. Spitler, L.E., Levin, A.S., Stites, D.P., Fudenberg, H.H., Huber, H.: The Wiskott-Aldrich syndrome. Immunologic studies in nine patients and selected family members. Cell. Immunol. 19, 201–218 (1975)

    PubMed  CAS  CrossRef  Google Scholar 

  277. Spitler, L.E., Levin, A.S., Stites, D.P., Fudenberg, H.H., Pirofsky, B., August, C.S., Stiehm, E.R., Hitzig, W.H., Gatti, R.A.: The Wiskott-Aldrich syndrome. Results of transfer factor therapy. J. clin. Invest. 51, 3216–3224 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  278. Srivastava, R.N.: Wiskott-Aldrich syndrome. Arch. Dis. Childh. 42, 604–607 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  279. St. Gerne jr., J.W., Prince JJIT., Burke, B.A., Good, R.A., Krivit, W.: Impaired cellular resistance to herpes-simplex virus in Wiskott-Aldrich syndrome. New Engl. J. Med. 273, 229–234 (1965)

    CrossRef  Google Scholar 

  280. St. Gerne jr., J.W., Prince, J.T., Burke, B.A., Krivit, W.: Studies of persistent herpes virus infection in children with the Aldrich syndrome. J. Pediat. 61, 302–303 (1962)

    CrossRef  Google Scholar 

  281. Stiehm, E.R.: Plasma Therapy: An Alternative to Gamma Globulin Injections in Immunodeficiency. In: Birth Defects, Orig. Art. Ser. Vol. XI/1, 343–346 (1975)

    Google Scholar 

  282. Stiehm, E.R., Ammann, A.J., Barnett, E.V., Craddock, CG., Fudenberg, H.H., Lawlor jr., G.J.: Disease of cellular immunity (UCLA conference). Ann. intern. Med. 77, 101–116 (1972)

    Google Scholar 

  283. Stiehm, E.R., Rudenberg, H.H.: Serum levels of immune globulins in health and disease: A survey. Pediatrics 37, 715–727 (1966)

    PubMed  CAS  Google Scholar 

  284. Stiehm, E.R., Mcintosh, R.M.: Wiskott-Aldrich syndrome: Review and report of a large family. Clin. exp. Immunol. 2, 179–189 (1967)

    PubMed  CAS  Google Scholar 

  285. Stiehm, E.R., Vaerman, J.-P., Fudenberg, H.H.: Plasma infusions in immunologic deficiency states: Metabolic and therapeutic studies. Blood 28, 918–937 (1966)

    PubMed  CAS  Google Scholar 

  286. Stoelinga, G.B.A.: Die kongenitalen humoralen Immundefizienzsyndrome. Pädiat. Pädol. 7, 3–13 (1972)

    CAS  Google Scholar 

  287. Stoelinga, G.B.A., van Munster, P.J.J., Sloof, J.P.: Antibody deficiency syndrome and autoimmune haemolytic anaemia in a boy with isolated IgM deficiency dysimmunoglobulinaemia type 5. Acta paediat. scand. 58, 352–362 (1969)

    PubMed  CAS  CrossRef  Google Scholar 

  288. Strauss, R.G., Hake, D.A.: Combined immunodeficiency disease with response to transfer factor. J. Pediat. 85, 680–682 (1974)

    PubMed  CAS  CrossRef  Google Scholar 

  289. Takemoto, K.K., Rabson, A.S., Mullarkey, M.F., Blaese, R.M., Garon, C.F., Nelson, D.: Isolation of Papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome. J. nat. Cancer Inst. 53, 1205–1207 (1974)

    PubMed  CAS  Google Scholar 

  290. Ten Bensel, R.W., Stadlan, E.M., Krivit, W.: The development of malignancy in the course of the Aldrich syndrome. J. Pediat. 68, 761–767 (1966)

    PubMed  CrossRef  Google Scholar 

  291. Thompson, R.B.: Lymphocyte transfer factor. Rev. europ. Etud. clin. Biol. 16, 201–204 (1971)

    CAS  Google Scholar 

  292. Tympner, K.D., Hager, K., Schweier, P.: Immunologische Untersuchungen beim Wiskott-Aldrich-Syndrom. Münch. med. Wschr. 110, 517–521 (1968)

    PubMed  CAS  Google Scholar 

  293. Ungari, S., Aiuti, F., Iacovacci, G.: Immunologische Aspekte des Wiskott-Aldrich-Syndroms. Helv. paediat. Acta 21, 351–355 (1966).

    PubMed  CAS  Google Scholar 

  294. Van Crefeld, S.: Idiopathic thrombocytopenic purpura. Pedait. int. (Roma) 9, 405–427 (1959)

    Google Scholar 

  295. Van den Bosch, J., Drukker, J.: Het syndroom van Aldrich; een klinisch en genetisch onderzoek van enige nederlandse families. Maandschr. Kindergeneesk. 23, 359–373 (1964)

    Google Scholar 

  296. Van Eys, J.: Sex-linked Thrombocytopenia. In: Birth Defects, Orig. Art. Ser. VIII/3, 145–150 (1972)

    Google Scholar 

  297. Van Loghem, J.J.: Chronische Virusinfektionen und Autoimmunkrankheiten. Transfus. Immunhaem. 1, 1–20 (1973)

    Google Scholar 

  298. Valentine, W.N.: Deficiencies associated with Embden-Meyerhof pathway and other meiabolic pathways. Semin. hemat. 8, 348–366 (1971)

    PubMed  CAS  Google Scholar 

  299. Vestermark, B., Vestermark, S.: Familial sex-linked thrombocytopenia. Acta paediat. (Uppsala) 53, 365–370 (1964)

    CAS  CrossRef  Google Scholar 

  300. Villares, E.S., Esteban, M.M., de Carlos Campos, A.M.: Sindrome de Wiskott-Aldrich. Apotacion de un caso. Rev. esp. Pediat. 19, 603–622 (1963)

    Google Scholar 

  301. Virelizier, J.-L., Griscelli, C.: Relation note-virus. I. Complications virales des deficits immunitaires congenitaux. Arch, franc. Pediat. 34, 813–819 (1977)

    CAS  Google Scholar 

  302. Volpato, S., de Ritis, L.: La sindrome di Wiskott-Aldrich (Contributo clinico ed immunoelettroforetico di tre casi). Acta paediat. lat. (Reggio Emilia) 21, 31–49 (1968)

    Google Scholar 

  303. Waldmann, T.A., Broder, S.: Suppressor Cells in the Regulation of the Immune Response. In: Progress in Clinical Immunology (Schwartz, R.S., ed.), pp. 155–199. New York: Grune & Stratton 1977

    Google Scholar 

  304. Waldmann, T.A., Polmar, S.H., Balestra, S.T., Jost, M.C., Bruce, R.M., Terry, W.D.: Immunoglobulin E in immunologic deficiency diseases. II. Serum IgE concentrations of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich syndrome. J. Immunol. 109, 304–310 (1972)

    PubMed  CAS  Google Scholar 

  305. Waldmann, T.A., Strober, W.: Metabolism of immunoglobulins. Progr. Allergy 13, 1–110 (1969)

    CAS  Google Scholar 

  306. Waldmann, T.A., Strober, W., Blaese, R.M.: Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann. intern. Med. 77, 605–628 (1972)

    Google Scholar 

  307. Waldmann, T.A., Strober, W., Blaese, R.M., Terry, W.D.: Immunoglobulin Metabolism in Disease. In: Birth Defects, Orig. Art. Ser. XI/1, 87–94 (1975)

    Google Scholar 

  308. Walzer, R.: Wiskott-Aldrich syndrome. Arch. Derm. 99, 372–373 (1969)

    CrossRef  Google Scholar 

  309. Wara, D.W., Ammann, A.J.: Activation of T-cell rosettes in immunodeficient patients by thymosin. Ann. N.Y. Acad. Sci. 249, 308–313 (1975)

    PubMed  CAS  CrossRef  Google Scholar 

  310. Weiden, P.L., Blaese, R.M.: Hereditary thrombocytopenia: Relation to Wiskott- Aldrich syndrome with special reference to splenectomy. Report of a family and review of the literature. J. Pediat. 80, 226–234 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  311. Weiner, L.P., Narayan, O.: Virologie studies of progressive leukoencephalopathy. Progr. med. Virol. 18, 229–240 (1974)

    CAS  Google Scholar 

  312. Weintraub, H.D., Wilson, W.J.: Pneumocystis carinii pneumonia in Wiskott-Aldrich syndrome. Amer. J. Dis. Child. 108, 198–200 (1964)

    PubMed  CAS  Google Scholar 

  313. Wells, J.V., Bleumers, J.F., Fudenberg, H.H.: Immunobiology of human anti-IgM iso-antibodies. I. Clinical and serological studies. Clin. Immunol. Immunopath. 1, 257–291 (1973)

    CAS  CrossRef  Google Scholar 

  314. West, C.D., Hong, R., Holland, N.H.: Immunoglobulin levels from the newborn and and in immunoglobulin deficiency states. J. clin. Invest. 41, 2054–2064 (1962)

    PubMed  CAS  CrossRef  Google Scholar 

  315. Weston, W.L.: Disorders of phagocyte function. Arch. Derm. 112, 1589–1596 (1976)

    PubMed  CAS  CrossRef  Google Scholar 

  316. White, J.C.: Ultrastructural defects in congenital disorders of platelet function. Ann. N.Y. Acad. Sci. 201, 205–233 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  317. White, J.G., Gerrard, J.M.: Ultrastructural features of abnormal blood platelets. A review. Amer. J. Path. 83, 590–632 (1976)

    Google Scholar 

  318. Wintrobe, M.M., Lee, G.R., Boggs, D.R., Bithell, T.C., Athens, J.W., Foerster, J.: Clinical Hematology. Philadelphia: Lea & Febiger 1974

    Google Scholar 

  319. Wiskott, A.: Familiärer, angeborener Morbus Werlhofii? Vortrag, 51. Ordentliche Tagung der Deutschen Gesellschaft für Kinderheilkunde, 22.–25. Juli 1936, Würzburg

    Google Scholar 

  320. Wiskott, A.: Familiärer, angeborener Morbus Werlhofii? Mschr. Kinderheilk. 68, 212–216 (1937)

    Google Scholar 

  321. Wiskott, A.: Wiskott-Aldrich-Syndrom. Vortrag, Tagung der Süddeutsch. Kinderärzte, 30.–31. Mai 1964, Freiburg

    Google Scholar 

  322. Wolff, J.A.: Wiskott-Aldrich syndrome: Clinical, immunologic, and pathologic observations. J. Pediat. 70, 221–232 (1967)

    PubMed  CAS  CrossRef  Google Scholar 

  323. Wolff, J.A., Bertucio, M.: A sex-linked genetic syndrome in a negro family manifested by thrombocytopenia, eczema, bloody diarrhea, recurrent infection, anemia, and epistaxis. Amer. J. Dis. Child. 93, 74 (1957)

    Google Scholar 

  324. Wybran, J., Carr, M.C., Fudenberg, H.H.: The human rosette-forming cell as a marker of a population of thymus-derived cells. J. clin. Invest. 51, 2537–2543 (1972)

    PubMed  CAS  CrossRef  Google Scholar 

  325. Wybran, J., Fudenberg, H.H.: How clinically useful is T and B cell quantitation? Ann. intern. Med. 80, 765–767 (1974)

    PubMed  CAS  Google Scholar 

  326. Wybran, J., Fudenberg, H.H.: Human Thymus-derived Rosette-forming Cells and Immunologic Diseases. In: Birth Defects, Orig. Art. Ser. XI/1, 7–9 (1975)

    Google Scholar 

  327. Wybran, J., Levin, A.S., Spitler, L.E., Fudenberg, H.H.: Rosette-forming cells, immunologic deficiency diseases and transfer factor. New Engl. J. Med. 288, 710–713 (1973)

    PubMed  CAS  CrossRef  Google Scholar 

  328. Yount, W.J.: Imbalances of IgG Subclasses and Gene Defects in Patients with Primary Hypogammaglobulinemia. In: Birth Defects, Orig. Art. Ser. XI/1, 99–107

    Google Scholar 

  329. Zinn, K.H., Belohradsky, B.H.: Wiskott-Aldrich Syndrom mit Verrucae vulgares. Hautarzt 28, 664–667 (1977)

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1978 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Belohradsky, B.H., Griscelli, C., Fudenberg, H.H., Marget, W. (1978). Das Wiskott-Aldrich Syndrom. In: Frick, P., von Harnack, GA., Martini, G.A., Prader, A., Schoen, R., Wolff, H.P. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 41. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67049-7_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67049-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67050-3

  • Online ISBN: 978-3-642-67049-7

  • eBook Packages: Springer Book Archive