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Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics pp 85–184Cite as

Das Wiskott-Aldrich Syndrom

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Zusammenfassung

Das klinische Bild und die Pathogeneseforschung des Wiskott-Aldrich Syndroms (WAS) sind aufgrund der charakteristischen Symptomentrias (thrombocytopenische Blutungen, gesteigerte Infektionsanfälligkeit, Ekzem) und des recessiv-geschlechtsgebundenen Erbganges nicht nur für den Pädiater von Interesse, sondern in gleichem Maß für den Hämatologen, Immunologen, Dermatologen und Genetiker (89, 106, 107, 113, 149, 152, 166, 191, 207, 222, 248, 260, 264, 265, 276, 286). Dennoch ist es, 40 Jahre nach der Erstbeschreibung, immer noch nicht gelungen, Ätiologie und Pathogenese des Syndroms zu klären. Damit fehlen auch weiterhin die Voraussetzungen für eine kausale Therapie und die eindeutige Abgrenzung von ähnlich verlaufenden Krankheiten.

Herr Prof. Dr. A. Wiskott zum 80. Geburtstag in Verehrung gewidmet.

Mit Unterstützung der Deutschen Forschungsgemeinschaft (Be 496/3)

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Authors and Affiliations

  1. Abteilung für Antimikrobielle Therapie und Infektionsimmunologie (Vorstand: Prof..Dr. W. Marget), Kinderklinik der Universität München im Dr. von Haunerschen Kinderspital (Direktor: Prof. Dr. K. Betke), Lindwurmstr. 4, D-8000, München 2, W-Germany

    B. H. Belohradsky & Prof. Dr. W. Marget

  2. Hôpital des Enfants Malades, Unité d’Immuno-Hématologie, 149 rue de Sèvres, F-75730, Paris Cedex 15, France

    Prof. agr. C. Griscelli

  3. Department of Basic and Clinical Immunology and Microbiology, Medical University of of South Carolina, 171 Ashley Avenue, Charleston, South Carolina, 29403, USA

    H. H. Fudenberg M.D. (Professor and Chairman)

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  1. B. H. Belohradsky
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  2. Prof. agr. C. Griscelli
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  3. H. H. Fudenberg M.D.
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  4. Prof. Dr. W. Marget
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P. Frick G.-A. von Harnack G. A. Martini A. Prader R. Schoen H. P. Wolff

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Belohradsky, B.H., Griscelli, C., Fudenberg, H.H., Marget, W. (1978). Das Wiskott-Aldrich Syndrom. In: Frick, P., von Harnack, GA., Martini, G.A., Prader, A., Schoen, R., Wolff, H.P. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 41. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67049-7_3

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