Abstract
Treatment of acute porphyric relapse with hematin has proven beneficial in 42 patients during the last 7 years (1, 5, 15). Clearance of hematin from plasma (10) and mechanisms of heme excretion have, however, been only partially explained (7). Plasma hematin is converted to bilirubin in the liver (7) and excreted in the bile (7, 14). Hematin administered i.v. has been observed in bile (11, 14) and in urine (3, 10). In the present work, the excretion of exogenous hematin was studied in bile fistula rats (12). The effect of hematin doses and mode of administration on biliary excretion was also investigated.
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Petryka, Z.J., Pierach, C.A. (1978). New Aspects of Hematin Excretion in Rats. In: Doss, M. (eds) Diagnosis and Therapy of Porphyrias and Lead Intoxication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67002-2_50
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DOI: https://doi.org/10.1007/978-3-642-67002-2_50
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