Comparison of Fluorometric Micromethods for Analyzing Erythrocytic Porphyrins (EP)

  • K. H. Schaller
  • R. Schiele

Abstract

Biologic and biochemical parameters for detection and judgement of increased occupational lead exposure have been known for several decades. This procedure may meet the need to avoid the still relatively sophisticated blood-lead analysis. On the other hand the determination of such data will hopefully lead to additional information about the extense of the harmful effects of lead on organisms (17). Few of the numerous biochemical parameters still used in the field of occupational medicine to determine an increased lead load have proved successful in routine operation. The methods generally used nowadays are of measuring δ-aminolevulinic acid in urine and δ-aminolevulinic-aciddehydratase activity of erythrocytes. Recent examinations confirm that the measurement of erythrocytic porphyrins (EP) is a specific and sensitive criterion of the influence of lead on man (1, 9, 15, 17, 20, 22). Fast and reliable fluorometric micromethods for the EP determination have been developed in recent years (4, 5, 6, 8, 9, 12, 13, 17).

Keywords

Zinc Expense Porphyrin Fluoro Erythro 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • K. H. Schaller
    • 1
  • R. Schiele
    • 1
  1. 1.Institute for Occupational and Social Medicine and Policlinic for Occupational Diseases of Erlangen-Nürnberg-UniversityGermany

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