Skip to main content
SpringerLink
Log in

Time Course and Compartment Relations of Heme-Synthesis Disturbances Induced by Inorganic Lead Compounds in Humans

  • Conference paper
Diagnosis and Therapy of Porphyrias and Lead Intoxication

Abstract

Connections between lead toxicology and porphyrinology date back as far as the early 1880s, when a rather legendary Dutch author named Binnendijk (4) supposedly reported for the first time the occurrence of a porphyrin body in the urine of a patient with lead poisoning. In 1892, Garrod (9) specified a crude method for the determination of what he called “haematoporphyrin,” which he ascribed to the decomposition of hemoglobin. Nevertheless, this initially misidentified porphyrin became for several decades an important means for preventive diagnosis of early saturnism. Duesberg (6) identified it as coproporphyrin III in 1931, and in 1936 Watson (21) was the first to speculate on influences of lead upon heme synthesis rather than its hemolytic effect, a concept that was settled by Rimington in 1937 (17) in his “enzymic theory of haemopoiesis.”

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Azar, A., Trochimowicz, H.J., Maxfield, M.E.: Review of lead studies in animals carried out at Haskell Laboratory - Two-year feeding study and response to hemorrhage study. In: Environmental Health Aspects of Lead, Internat. Symposium 1972, ed. by CED Centre for Information and Documentation, Luxembourg 1973, pp. 199-210

    Google Scholar 

  2. Baloh, R.W.: Laboratory diagnosis of increased lead absorption. Arch. Environ. Health 28, 198–208 (1974)

    PubMed  CAS  Google Scholar 

  3. Berlin, A., Schaller, K.H.: European standardized method for determination of δ-aminolevulinic acid dehydratase activity in blood. Z. Klin. Chem. Klin. Biochem. 12, 389–390 (1974)

    PubMed  CAS  Google Scholar 

  4. Binnendijk, J., cited by Stokvis, B.J.: Zur Pathogenese der Hamatoporphyrinurie. Z. Klin. Med. 28, 1 (1895)

    Google Scholar 

  5. Bonsignore, D., Calissano, P., Cartasegna, C.: Un semplice metodo per la determinazione della δ-amino-levulinico-deidratasi nel sangue. Med. Lav. 56, 199–205 (1965)

    PubMed  CAS  Google Scholar 

  6. Duesberg, R.: Über die Anamien. - I. Porphyrie und Erythropoese. Arch. Exp. Pathol. 162, 249 (1931)

    Article  Google Scholar 

  7. Gajdos, A.: Folia Med. (Napoli) 40, 1 (1957)

    CAS  Google Scholar 

  8. Kautzsch, E.: Hamsynthesestörungen bei Leberkrankheiten. Med. Klin. 41, 1731–1734 (1962)

    Google Scholar 

  9. Gajdos, A., reported by Kehoe, R.A.: Standards for the prevention of occupational lead poisoning. Arch. Environ. Health 23, 245–248 (1971)

    Google Scholar 

  10. Garrod, A.E.: On the occurrence and detection of haematoporphyrin in the urine. J. Physiol. 13, 598 (1892)

    PubMed  CAS  Google Scholar 

  11. Gibson, K.D., Neuberger, A., Scott, J.J.: The purification and properties of delta-amino-levulinic-dehydrase. Biochem. J. 61, 618–629 (1955)

    PubMed  CAS  Google Scholar 

  12. Grabecki, J., Haduch, T., Urbanowicz, H.: Die einfachen Bestimmungsmethoden der δ-Aminolavulinsaure im Ham. Int. Arch. Gewerbepath. Gewerbehyg. 23, 226–240 (1967)

    Article  CAS  Google Scholar 

  13. Haeger, B.: Increased content of a δ-aminolaevulic acid-like substance in urine from workers in lead industry. Scand. J. Clin. Lab. Invest. 9, 211–212 (1957)

    Article  PubMed  CAS  Google Scholar 

  14. Heilmeyer, R.: Die Störungen der Bluthamsynthese. Stuttgart: Georg Thieme 1964, pp. 113–122

    Google Scholar 

  15. Hijmans v.d. Bergh, A.A., Hijman, A. J. : Studien über Porphyrin. Dtsch. Med. Wochenschr. 54, 1492–1494 (1928)

    Google Scholar 

  16. Hijmans v.d. Bergh, A.A., Grotepass, W., Revers, F.E.: Beitrag uber das Porphyrin in Blut und Galle. Klin. Wochenschr. 11, 1534–1536 (1932)

    Article  Google Scholar 

  17. Mauzerall, D., Granick, S.: The occurrence and determination of 6-aminolevulinic acid and porphobilinogen in urine. J. Biol. Chem. 219, 435–446 (1956)

    PubMed  CAS  Google Scholar 

  18. Rimington, C.: An enzymic theory of haemopoiesis. C. R. Trav. Lab. Carlsberg 22, 454 (1937)

    Google Scholar 

  19. Rubino, G.F., Prato, V.: Significato clinico della porfirinemia nel saturnismo. G. Accad. Med. (Torino) I, 6–9 (1955)

    Google Scholar 

  20. Schlegel, H., Nowacki, S.: Der Wert einer einfachen delta-Aminolavulinsaurebestimmung für die werksärztliche Überwachung bleigefährdeter Arbeiter. Arbeitsmed. Sozialmed. Arbeitshyg. 3, 308–309 (1968)

    Google Scholar 

  21. Schlegel, H., Leinberger, H.: Die Bestimmung des freien Erythrozyten-Protoporphyrins (PPE) in der werksärztlichen Überwachung bleigefahrdeter Arbeiter. Arbeitsmed. Sozialmed. Arbeitshyg. 4, 271–273 (1969)

    Google Scholar 

  22. Watson, C.J.: Concerning the naturally occurring porphyrins. IV. The urinary porphyrin in lead poisoning as contrasted with that excreted normally and in other diseases. J. Clin. Invest. 15, 327 (1936)

    Article  PubMed  CAS  Google Scholar 

  23. Watson, C.J., Sutherland, D., Hawkinson, V.: Studies of coproporphyrin: V. The isomer distribution of per diem excretion of the urinary coproporphyrin in cases of cirrhosis of the liver. J. Lab. Clin. Med. 37, 8 (1951)

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Werksärztlicher Dienst der Daimler-Benz A.G, 7032, Sindelfingen, Germany

    G. Kufner

Authors
  1. H. Schlegel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Kufner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Clinical Biochemistry, Faculty of Medicine, Philipp University of Marburg, Pilgrimstein 2, D-3550, Marburg, Federal Republic of Germany

    Manfred Doss

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schlegel, H., Kufner, G. (1978). Time Course and Compartment Relations of Heme-Synthesis Disturbances Induced by Inorganic Lead Compounds in Humans. In: Doss, M. (eds) Diagnosis and Therapy of Porphyrias and Lead Intoxication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67002-2_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67002-2_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08863-9

  • Online ISBN: 978-3-642-67002-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation