Influence of Environmental Factors on Porphyrin Metabolism

  • N. Simon
  • Cs. Siklósi
  • F. Kószó
Conference paper


Investigations of the influence of environmental factors on organisms are made nowadays on an interdisciplinary level. We do not wish to deal here with the acutely toxic nature of certain herbicidal compounds, nor with the symptoms of their toxicity and sensitization appearing on the skin; rather their damaging influence on the metabolismespecially on the porphyrin metabolism — is to be briefly discussed, an area on which very little literature is available.


Lipoid Structure Porphyria Cutanea Tarda Heme Enzyme Hepatic Porphyria Porphyrin Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bleiberg, J., Wallen, M., Brodkin, R. : Industrially acquired porphyria. Arch. Dermatol. 89, 793–797 (1964)PubMedCrossRefGoogle Scholar
  2. 2.
    Cam, C.: Cases of skin porphyria related to hexachlorobenzene intoxication. Saglik Dergisi (Ankara) (in Turkish) 32, 215–217 (1958)Google Scholar
  3. 3.
    Hennenberg, M.: Methemoglobinémie, coproporphyrinurie et urobilinogénurie chez le rat au cours de 1’intoxication experimentale par les herbicides dérivés du dinitophénol: DNBP (Dinosebe) et DNPP (Dinoprobe). Eur. J. Toxicol. 4, 9–18 (1971)Google Scholar
  4. 4.
    Jirásek, L., Kalensky, J., Kubec, K., Pazderová, J., Lukas, E.: Chlorakne, Porphyria cutanea tarda und andere Intoxikationen durch Herbizide. Hautarzt 27, 328–333 (1976)PubMedGoogle Scholar
  5. 5.
    Simon, N., Siklósi, Cs.: Experimentelles Porphyrie-Modell mit Hexachlor-Cyklohexan. Z. Hautkr. 49, 497–504 (1974)PubMedGoogle Scholar
  6. 6.
    Simon, N., Siklósi, Cs., Kószó, F.: The Role of Damages in Cellular Membrane Structures in the Development of Porphyria cutanea tarda. In: “Porphyrins in Human Diseases”. First International Porphyrin Meeting, Freiburg/Br., May 1-4, 1975. Basel: Karger 1976Google Scholar
  7. 7.
    Vos, J.G., Strik, J.J.T.W.A., Holstein, C.W.M., van Pennings, J.H.: Polychlorinated biphenyls as inducers of hepatic porphyria in japanese quail, with special references - aminolevulinic acid synthetase activity, fluorescence, and residues in the liver. Toxicol. Appl. Pharmacol. 20, 232–240 (1971)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • N. Simon
  • Cs. Siklósi
  • F. Kószó
    • 1
  1. 1.Department of Dermatology and VenerologyUniversity School of MedicineSzegedHungary

Personalised recommendations