Therapy of Acute Intermittent Porphyria With Ovulation Inhibitors in Women

  • G. Schley
  • W. Hengstebeck
  • K. D. Bock
Conference paper


Acute intermittent porphyria is a metabolic disease that is characterized by recurrent attacks. It mainly affects women and is biochemically characterized by excessive excretion of porphyrins and their precursors. The prognosis is poor. Patients frequently die due to cessation of respiration after surviving some attacks. Sometimes peripheral pareses occur that do not subside completely. An effective treatment is not yet known. Attacks of acute intermittent porphyria are often related to menstruation in women (1). Participation of female sexual hormones and/or gonadotrophins is discussed, therefore, as a possible cause of acute attacks. Because of the proved inhibition of the secretion of gonadotrophins by combinations of estrogens and gestagens we used ovulation inhibitors for the prophylactic treatment of acute intermittent porphyria.


Oral Contraceptive Lation Inhibitor Acute Attack Bilateral Oophorectomy Recurrent Attack 
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  1. 1.
    Schley, G., Anlauf, M., Bock, K.D.: Akute intermittierende Porphyrie. Beobachtungen bei 17 Fallen mit 49 akuten Schuben. Med. Klinik 71, 1891–1897 (1976)Google Scholar
  2. 2.
    Schley, G., Anlauf, M., Bock, K.D.: Orale Kontrazeptiva zur Prophylaxe akuter Schube der intermittierenden Porphyrie. Dtsch. Med. Wschr. 101, 1901–1907 (1976)PubMedCrossRefGoogle Scholar
  3. 3.
    Schley, G., Bock, K.D., Werner, U.: Persistierende arterielle Hypertonien bei akuter intermittierender Porphyrie unter Behandlung mit Ovulationshemmern. Verh. Dtsch. Ges. Inn. Med. 81, 1061–1063 (1975)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • G. Schley
  • W. Hengstebeck
  • K. D. Bock
    • 1
    • 2
  1. 1.Medical Department of City HospitalVelbertGermany
  2. 2.Division for Renal Diseases and Hypertension, Department of MedicineUniversity of EssenGermany

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