Secretion of growth hormone (hGH) in response to cold and heat has been studied in normal adult subjects aged 21 to 38 years (2 males and 4 females) exposed to 4°C for 1 or 2 h. Body temperature decreased to less than 34°C in all cases. The serum level of Cortisol increased from 18.4 to 23.8 μg/100 ml in one subject, but changed little in the others. FFA increased progressively to 113%, 136%, 226%, and 268% of the initial value in four of the subjects. Levels of hGH did not change or decrease during cooling, but increased from less than 1.1 ng/ml to more than 4.2 ng/ml (7.48 ± 4.13 ng/ml) on rewarming. Figure 1 shows a typical pattern of hGH secretion during and after cold exposure. An insulin tolerance test at a dose of 0.05 U/kg of body weight was performed on the two male subjects during cold exposure. hGH values reached maxima of 32 and 7 ng/ml in the two subjects. Two female subjects were given 20 mg of propranolol orally and then exposed to cold air for 1 h. FFA changed little throughout the test. Levels of hGH did not increase during cooling, but increased from 1.7 and 2.2 to 9.5 and 6.8 ng/ml, respectively, on rewarming. There were no significant changes in hGH levels in control subjects held at room temoerature (Okada et al., 1970).
- Growth Hormone
- Male Subject
- Cold Exposure
- Heat Exposure
- Insulin Tolerance Test
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OKADA, Y., MIYAI, K., IWATSUBO, H., KUMAHARA, Y.: Human growth hormone secretion before and after cold exposure in normal adult subjects. J. Clin. Endocrinol. Metab. 30, 393–395 (1970)
OKADA, Y., MATSUOKA, T., KUMAHARA, Y.: Human growth hormone secretion during exposure to hot air in normal adult male subjects. J. Clin. Endocrinol. Metab. 34, 759–763 (1972)
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© 1978 Springer-Verlag Berlin Heidelberg
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Okada, Y., Kumahara, Y. (1978). Human Growth Hormone Secretion in Responses to Cold and Heat. In: Assenmacher, I., Farner, D.S. (eds) Environmental Endocrinology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66981-1_47
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Print ISBN: 978-3-642-66983-5
Online ISBN: 978-3-642-66981-1
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