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In Vitro and in Vivo Investigations on Antibody-Dependent Cellular Cytotoxicity

  • Gary R. Pearson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 80)

Abstract

It is now well established that target cell destruction can be mediated through the interaction of antibody with normal lymphoid cells as well as through the classic T-cell immunity mechanism (Cerottini and Brunner, 1974). This phenomenon, recently reviewed by Perlmann, Perlmann, and Wigzell (1972), was first described by Möller in 1965 and has received a number of designations, including antibody-dependent cell-mediated (or cellular) cytotoxicity (ADCC), antibody-dependent lymphocyte cytotoxicity (ADLC), cell dependent antibody-mediated cytotoxicity (CDAMC), and lymphocyte-dependent antibody (LDA). For the purpose of this review, this immunologic reaction will be referred to as ADCC.

Keywords

Effector Cell ADCC Activity Cytotoxic Reaction Normal Human Lymphocyte Murine Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • Gary R. Pearson
    • 1
  1. 1.Mayo Clinic/Foundation and Mayo Medical SchoolRochesterUSA

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