Pharmacokinetics of 4-HydroxyButyric acid Used as a Sedative in the Intensive Care Unit

  • A. G. van den Bogert
  • T. B. Vree
  • E. van der Kleijn
  • J. Damsma
Part of the Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine book series (A+I, volume 110)


4-hydroxybutyric Acid (GHB) is an interesting drug for several reasons. It is a naturally occuring compound in the brain of several mammals (1), when administered parenterally it produces a state of central nervous depression (2, 3).


Deep Sedation Artificial Ventilation Succinic Semialdehyde Plasma Concentration Curve Tracheal Suction 
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© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • A. G. van den Bogert
  • T. B. Vree
  • E. van der Kleijn
  • J. Damsma

There are no affiliations available

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