Abstract
The sequence of events occurring between the administration of digoxin and its therapeutic effect is very complex. The generalities of this sequence which can be applied to any drug are depicted in Figure 20.1.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aronson, J.K., Grahame-Smith, D.G., Hallis, K.F., Hibble, A., Wigley, F.: Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response. Br. J. Clin. Pharmacol. (in press) (1977)
Astrup, J.: Sodium and potassium in human red cells: Variations among centrifuged cells. Scand. J. Clin. Lab. Invest. 33, 231–237 (1974)
Cohen, I., Dant, J., Noble, D.: The influence of extracellular potassium ions on the action of ouabain in membrane currents in sheep Purkinjee fibres. J. Physiol. (Lond.) 249, 42–43 (1975)
Grahame-Smith, D.G., Everest, M.S.: Measurement of digoxin in plasma and its use in the diagnosis of digoxin intoxication. Br. Med. J. 1969/i, 286
Ingelfinger, J., Goldman, P.: The serum digitalis concentration — does it diagnose digitalis toxicity. N. Engl. J. Med. 294, 867–870 (1976)
Love, W.D., Burch, G.E.: A comparison of 42potassium, 86rubidium, and 134caesium as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J. Lab. Clin. Med. 41, 351–362 (1953)
Schatzmann, H.J.: Herzglycoside als Hemmstoffe für aktiven Kalium und Natriumtransport durch die Erythrocytenmembran. Helv. Physiol. Acta 11, 346–354 (1953)
Schwartz, A., Lindenmayer, G.E., Allen, J.C.: The sodium-potassium adenosine triphosphatase: pharmacological, physiological and behavioural aspects. Pharmacol. Rev. 27, 3–134 (1975)
Wang, C.H., Willis, D.L.: In: Radiotracer Methodology in Biological Science. New Jersey: Prentice-Hall 1965, p. 31
Chan, Sanslone: Arch. Biochem. Biophys. 134, 48 (1969)
Greeff, K.: Eur. J. Pharmacol. 37, 89 (1976)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Grahame-Smith, D.G., Aronson, J.K. (1978). Assessment of Digoxin Action by a Pharmacodynamic Biochemical Method. In: Bodem, G., Dengler, H.J. (eds) Cardiac Glycosides. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66904-0_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-66904-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08692-5
Online ISBN: 978-3-642-66904-0
eBook Packages: Springer Book Archive