Abstract
The availability of isotope-labeled cardiac glycosides and the development of the radioimmunoassay made possible for the first time extensive studies on the pharmacokinetics of those cardioactive substances. In the meantime many data have been collected and have contributed to our basic knowledge of the metabolism and the disposition of these very important drugs. There is no doubt, however, that even before these data were available, cardiac glycosides were used very successfully in therapeutics and were handled by rather strict dosage schedules. Historically, they represented the first group of medicines for which — due to their long-lasting action and the need for continuous treatment — therapeutic regimes were established on a mathematical basis (Augsberger, 1951, 1954). It is particularly noteworthy that these calculations were performed without any knowledge of drug concentrations but by the use of analysis of clinical data on drug effects only; this is a rather modern approach.
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Dengler, H.J., Bodem, G., Gilfrich, H.J. (1978). Digoxin Pharmacokinetics and Their Relation to Clinical Dosage Parameters. In: Bodem, G., Dengler, H.J. (eds) Cardiac Glycosides. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66904-0_18
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