Toxicokinetics

  • Ole Karlog
  • Poul Nielsen
  • Folke Rasmussen
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 1)

Abstract

The absorption, distribution and elimination of toxic compounds can be described by means of kinetic parameters such as used in pharmacology. Administration of toxic doses may lead to changes in some of these parameters. The toxic effect may further influence the known parameters of some test substances.

Toxicokinetic parameters will be described using examples from two groups of compounds 1) naturally occurring toxic compounds and 2) synthetic compounds.

Changes in elimination parameters caused by toxic substances will be demonstrated a.o. the effect of long term intake of ochratoxin A and methoxyethyl mercury on the kidney function in swine. In both examples are demonstrated a pronounced reduction in the clearances of inulin and para-aminohippuric acid.

Furthermore, an elucidation of concentration dependent changes in enzyme activity and changes in metabolism of pesticides will be given. As examples alkylphosphates and dinitrophenols in domestic animals will be used.

Keywords

Mercury Radionuclide Atropine Methoxy Oxime 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Ole Karlog
    • 1
  • Poul Nielsen
    • 1
  • Folke Rasmussen
    • 1
  1. 1.Department of Pharmacology and ToxicologyRoyal Veterinary and Agricultural UniversityCopenhagen VDenmark

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